Food-Drug Interactions: Pharmacokinetics, Prevention and Potential Side Effects

Fernando Ramos, Ph.D., Margarida Caramona, Ph.D. and Isabel Vitória Figueiredo, Ph.D. (Editors)
Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal

Series: Food Science and Technology
BISAC: TEC012000

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The interaction between drugs and food is an increasingly relevant topic in clinical practice. There are numerous possibilities for interactions between drugs and food, often unknown or ignored by both health professionals and patients. The success of the care given to each patient depends, to a large extent, on the knowledge regarding the risks of associating drugs and foods. These interactions can be decisive in achieving therapeutic success due to interferences not only in the pharmacokinetics and pharmacodynamics of the drugs, with direct implications in the effectiveness and safety of the drugs, as well as in the absorption of nutrients.

This aspect becomes even more relevant in patients with chronic pathology in which the coexistence of the drug/food binomial is prolonged over time.

The objective of this book was to carry out a review on the main drug-food interactions and their impact on health. In this book, the most prevalent chronic pathologies in the population are referenced.

In addition to an introductory chapter on this subject, the following chapters address the impact of the vehicles used in the different pharmaceutical formulations for the oral route.
Taking this into account, aspects of potential interactions in the digestive and hepatic system, in diseases such as diabetes mellitus, chronic kidney disease, heart disease, dyslipidemia and cancer disease are presented. Additionally, the relevance of interactions between drugs and products of plant origin are also described.

Finally, the authors present a “case study”, with the main focus on the evaluation of potent interactions between antihypertensive and anti-dyslipidemic drugs and foods, carried out in a community pharmacy.

The authors believe that this book is of general interest, with greater relevance to health professionals, namely doctors, pharmacists, nurses and nutritionists, in order to facilitate quicker assessments of potential interactions and risks arising from the prescription of medicines and concomitant use with food.

Preface

Chapter 1. Interactions and Incompatibilities between Drugs and Vehicles Used in Oral Administration (pp. 1-14)
(Conxita Mestres)

Chapter 2. Hepatic and Digestive Systems and Food Interactions (pp. 15-56)
(João Filipe Gomes, Jorge Bastos Mendes and Manuel Teixeira Veríssimo)

Chapter 3. Food and Drug Interactions in Diabetes (pp. 57-70)
(Manuela Carvalheiro and Paula Barroso)

Chapter 4. Food-Drug Interactions in Chronic Kidney Disease (pp. 71-120)
(Teresa M. Salgado and Rachel W. Flurie)

Chapter 5. Heart Diseases and Food Interactions (pp. 121-158)
(Marta Madeira, Liliana Reis and Lino Gonçalves)

Chapter 6. Dyslipidemia and Food-Drug Absorption Interactions (pp. 159-170)
(José Manuel Silva)

Chapter 7. Food and Chemotherapy Interactions (pp. 171-182)
(Inês Brandão Rêgo, Nadine Saraiva, Nuno Bonito, António Pêgo, and Gabriela Sousa)

Chapter 8. Pharmacokinetics and Pharmacodynamics in Interactions between Medicinal Herbs and Drugs (pp. 183-206)
(Gert Laekeman)

Chapter 9. Interactions between Drugs and Herbal Teas (pp. 207-226)
(Maria Graça Campos, Carolina Bento , Inês Zorrinho and Ana Paula Leite)

Chapter 10. Herbal Products and Their Interactions with Anti-Hypertensive and Lipid-Lowering (pp. 227-250)
(Anabela Almeida, Margarida Caramona, Isabel Vitória Figueiredo and Fernando Ramos)

About the Editors (pp. 251-252)

Index (pp. 253)

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