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Quick ViewThe rising incidence of melanoma makes this tumor an important public health problem. Standard systemic therapies have not been adequately effective in the management of melanoma. Moreover, melanoma is resistant to antiangiogenesis therapy suggesting the existence of an alternative blood circulation system. For years sprouting angiogenesis has been considered as exclusive mechanism of tumor vascularization.…
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Cytochromes P450 1A sub-family (CYP1A1 and CYP1A2) are well-known metabolizers of anthropogenic compounds such as polycyclic aromatic hydrocarbons (PAHs) and arylamines. They catalyze all metabolic reactions occurring with PAHs in the organism including the ones resulting in the formation of carcinogenic, mutagenic and teratogenic substances. PAH in their intact, exogenous form usually do not produce…
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Quick ViewThis book presents original results on the leading edge of cancer research. Topics discussed include curcumin; diagnosis of thyroid cancers in the era of molecular medicine; xerostomia; the potential role of arsenic trioxide in the treatment of iodine non-avid thyroid cancer; causes of xerostomia in the cancer treatment; and an alternative for preparing the cancer…
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Quick ViewPhotodynamic therapy (PDT) is a well-established clinical modality for cancer, cardiovascular, ophthalmic, dermatological, and dental diseases. PDT is based on the activation of photosensitizer agents with specific wavelength of light, which results in energy transfer cascades that ultimately yield cytotoxic reactive oxygen species that can render cell death. This book discusses the fundamentals, applications and…
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Quick ViewCholangiocarcinoma is a devastating illness with poor long-term survival. The diagnosis and treatment of cholangocarcinoma is becoming increasingly important, particularly with the increasing incidence of hepatocellular carcinoma, another primary liver tumor. Since the diagnosis, treatment, and prognosis of the two similar malignancies vary tremendously, a thorough understanding of cholangiocarcinoma is vital for any practitioner dealing…
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Quick ViewAs the definition of palliative-intent radiation therapy (RT) continues to evolve, the application of advanced radiotherapeutic technologies, such as intensity-modulated RT, and techniques, such as image-guidance, are no longer the provision solely of the curative realm. Treatment options previously considered strictly palliative are expanding, with conventional RT being delivered in conjunction with other modalities such…
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Quick ViewFanconi Anemia (FA), a rare genetic disease featuring excess cancer risk and chromosomal instability, has received growing interest after the discovery that one of the defective genes in FA is associated with high-impact diseases such as familial breast cancer and ovary cancers. A well-documented relationship has accumulated in several decades and up to recently, studies…
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Quick ViewCholangiocarcinoma presents a challenge for cancer specialists all over the world. Neoplasia of the biliary tract are rare, accounting for approximately 3% of all gastrointestinal tumours with an incidence of about three per 100,000; but rates have been rising rapidly in recent years. This cancer is one of the major killers: at the time of…
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Quick ViewOver 50,000 new cases of head and neck cancer are diagnosed each year in the United States. The majority of these are squamous cell carcinoma (HNSCC), associated with human papillomavirus infection and carcinogenic behaviors such as tobacco use and alcohol consumption. Although these are more common, there are several other causes that this book addresses.…
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Quick ViewThis book presents original results on the leading edge of cancer research. Topics discussed include malignancy-related ascites; targeting cathepsin b for cancer therapies; cancer stem cells; metallomics of brain tumors; hepatitis b virus and Hepatitis C virus infections and risk of pancreatic ductal adenocarcinoma; the risk and prognostic factors associated with undifferentiated nasopharyngeal carcinoma; widespread…
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Quick ViewMantle cell lymphoma (MCL) is a subtype of Non-Hodgkin’s Lymphoma (NHL) with varying clinical presentations, ranging from indolent disease to highly aggressive symptoms. MCL represents approximately 3-10% of non-Hodgkin lymphomas, and has increased in incidence over the past several decades. The majority of patients respond to initial therapy, but remission duration is typically short. This…
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Quick ViewAs the definition of palliative-intent radiation therapy (RT) continues to evolve, the application of advanced radiotherapeutic technologies, such as intensity-modulated RT, and techniques, such as image-guidance, are no longer the provision solely of the curative realm. Treatment options previously considered strictly palliative are expanding, with conventional RT being delivered in conjunction with other modalities such…
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Quick ViewThe dominant role of the immune system in managing homeostasis of distinct normal tissues and in stimulating cancer growth in regenerative medicine for gonadal infertility and aging diseases, effective immunotherapy without adverse events of inoperable epithelial ovarian cancers (EOCs), and long-lasting cancer immune prophylaxis are reported. Beside their well–known role in immunity, the blood mononuclear…
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Quick ViewThis book presents original results on the leading edge of cancer research. Topics discussed include oral cancer cachexia; the immunological mechanisms of cachexia; research in gynecologic oncology today; advances in cellular understanding of muscle wasting in cachexia; and next generation sequencing developments in cancer research by bioinformatics approaches. (Imprint: Nova Biomedical)
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Quick ViewThis book presents original results on the leading edge of cancer research. Topics discussed include the emerging roles of the Sirtuin family in cancer; coping with pain in children with leukemia; chemotherapy induced peripheral neurotoxicity; historical evolution of conservative surgery of breast cancer; peripheral neuropathies especially in cancer patients; the important pitfalls in the diagnosis…
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Quick ViewKidney cancer is the 10th most common cancer in Europe with overall mortality rates increasing until the late 1980s and early 1990s and thereafter, stabilized. Until recently, renal cell carcinoma (RCC) was thought to represent a monomorphic disease; however, modern genetic characterization has demonstrated different subtypes with specific cell types and molecular metabolism. Imaging diagnostic…
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Quick ViewThis book covers the basic experimental models in glioblastoma research. It starts with a description in the first two chapters of general clinical, neuroimaging and genetic data about glioblastoma (WHO grade IV glioma), which is the most frequent and the most malignant primary tumor in adults. Despite the complex treatment which includes neurosurgery, radiotherapy and…
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Quick ViewThis encyclopedia presents important research on lung cancer. Some of the topics discussed herein include therapeutic antibodies in non-small cell lung cancer; radiation therapy; epigenetics; paraneoplastic syndromes associated with lung cancer; palliative radiotherapy treatments; bone and lung metastases; and asymptomatic presentation of lung and bone metastases in patients with breast cancer. (Imprint: Nova Biomedical)
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Quick ViewLung cancer, the most common and deadliest malignancy worldwide, is one of the biggest challenges for modern oncology. Although lung cancer presents the same incidence as breast or colorectal cancer, it causes as much deaths as breast and colorectal cancers together. Lung cancer demands our abilities as researchers, physicians, and care-givers in a multidisciplinary approach.…
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Quick ViewThe questions we ask in this book about cancer are actually quite elementary. What is the origin of cancer? Does cancer arise in any cell in the body, or only in certain cells? Is cancer a genetic or a stem-cell disease? We illustrate that cancer is a multicellular rather than a unicellular process, a cellular…
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In the opening chapter, authors discuss the current literature that describes the application of Palliative Medicine services in advanced cancer, models of Palliative Care delivery by site and mode of practice, cost-effectiveness of early Palliative Medicine referral patterns and national and international Palliative Medicine practice and referral guidelines. The chapter will also discuss the outcomes…
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Quick ViewIn early stages of cancer, patients are often presented with treatment options and encouraged to have shared treatment decisions with their oncologists. Shared decision making becomes particularly important, as several treatment options with different possible outcomes and adverse events exist. For example, women with early breast cancer are counseled on the options of mastectomy versus…
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Quick ViewMany cancer patients experience a variety of distressing symptoms, adversely affecting their functional status and quality of life (QOL). Subjective symptoms such as pain, fatigue and depression are common among cancer patients, with approximately 33-55% of cancer patients experiencing pain during the course of their illness. Previous literature commonly examined a single symptom and its…
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Quick ViewSeveral medical options in palliative care can have complex moral, religious, cultural, medical and legal issues. These treatment options, such as assisted suicide, rehydration, parenteral nutrition and cardiopulmonary resuscitation have been heavily debated in the literature. Physician-assisted suicide is a controversial topic for debate, with growing pressure from advocacy groups for legalization in regions that…
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