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Quick ViewThe diagnosis and treatment of Diffuse large B-cell lymphoma (DLBCL) have evolved significantly in the past decade. With advances in our understanding of DLBCL through the application of immunophenotypic, molecular cytogenetic analysis and clinical correlation, a growing number of discrete subtypes and entities of DLBCL have been recognized, along with improved prognostic stratification and treatment…
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Quick ViewThis book provides research on ependymomas, a rare brain tumor that arises from the ependymal cells of the intra-ventricular central nervous system (CNS) parenchyma with a propensity to affect both children and adults. Ependymomas account for only 1.9% of all primary brain and CNS tumors. Chapter One discusses the prognosis and outcomes in patients with…
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Quick ViewThis book presents original results on the leading edge of cancer research. Chapter One explains unanswered questions of contemporary oncology from the standpoint of karyogamic theory of carcinogenesis. Chapter Two focuses on the molecular players of the human papillomaviruses (HPVs) infection leading to chronic inflammation and cancer. Chapter Three describes Multiple Myeloma (MM), and Monoclonal…
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Quick ViewHorizons in Cancer Research. Volume 71 begins by reviewing the histopathological features of head and neck squamous cell carcinoma and its precursor lesions, risk factors for head and neck squamous cell carcinoma including viral infection, chemical carcinogenic and ethnic predisposition. New knowledge about major pathways and signaling is also presented. Next, the clinical development of…
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Quick ViewThe Easy Book of Cancer Pharmacology represents the efforts of young oncologists, haematologists, pharmacists and oncology nurses who are highly motivated and encouraged by the significant development of new effective anticancer drugs. Since the discovery of antimetabolites and alkylating agents in the 1940s and 1950s, many new products have been introduced into our daily arsenal…
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Quick ViewBesides surgery, radiation therapy, endocrine therapy or chemotherapy, which were widely used in cancer patients for decades, the 21st century has seen the emergence of “targeted” therapy, resulting from the identification of molecular pathways in cells and their alterations in tumors. An increasing number of compounds targeting specific molecules or cancer cells have been developed…
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Quick ViewPrimary bile duct cancers are rare and generally aggressive entities. Historically, this disease was managed exclusively with surgical therapy with few long-term survivors. However, with improvements in chemotherapeutics, targeted therapy, interventional radiology techniques and development of alternative surgical approaches, treatment has moved to the utilization of a multidisciplinary care team employing multimodality treatments which has…
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Quick ViewThe blood cell system has provided a model system that has been used by many researchers to investigate how a stem cell can give rise to a wide variety of mature cell types. The principles that emerged in developmental biology have been applied to the structure of tissues throughout the body. However, many of the…
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Quick ViewBreast tumors are one of the most worrisome and challenging problems for surgeons and pathologists. In this book, the authors present research in the study of the epidemiology, management and prevention of breast tumors; some examples of these types of breast cancer are DCIS, LCIS, IDC, ILC, medullary carcinoma, metaplastic carcinoma, papillary carcinoma, adenoid cystic…
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This book offers a unique insight into the “medulloblastoma world,” and provides both a broad review and detailed analysis of this brain tumour. It starts with the history of medulloblastoma as a term, and as a distinct entity in nosology, and then explores in depth, the diagnosis, genetics, neurosurgical, and oncological management of medulloblastoma patients,…
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Quick ViewThis book presents original results on the leading edge of cancer research. Chapter One summarizes what is currently known regarding the epigenetic regulation of osteosarcoma pathways and oncogenes, as well as clinical trials of drugs that exert epigenetic regulation. Chapter Two critically discusses the role of ECM-dependent signaling in osteosarcoma progression. Chapter Three illustrates the…
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Quick ViewChronic Lymphocytic Leukemia (CLL) is the most common leukemia in the western world, seen mostly in the elderly age-group and has a very variable clinical outcome. Traditionally considered an indolent, antigen inexperienced leukemia of slowly accumulating cells that do not die, researchers now acknowledge that CLL cells are highly proliferative, antigen experienced cells that have…
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Quick ViewThis personal scientific memoir describes how a chance observation concerning artery disease in children with rare inherited abnormalities of metabolism, often called experiments of Nature, led to the discovery of a new theory of heart disease, cancer and diseases of aging. As explained in subsequent chapters, this new theory places the amino acid homocysteine at…
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Quick ViewGastrointestinal cancer is the most frequently diagnosed type of cancer all around the globe. Gastrointestinal cancer is the cancer of different organs of the digestive system including the esophagus, stomach, liver, gallbladder, pancreas, small intestine, large intestine, rectum and anus. The common cause of gastrointestinal cancer may be microbial infection, smoking, alcohol consumption, high fat…
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Quick ViewGastrointestinal cancer is the most frequently diagnosed type of cancer worldwide. Gastrointestinal cancer is the cancer of different organs within the digestive system, including the esophagus, stomach, liver, gallbladder, pancreas, small intestine, large intestine, rectum and anus. The common cause of gastrointestinal cancer may be a microbial infection, smoking, alcohol consumption, highly fatty foods, age,…
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Quick ViewThis book presents original results on the leading edge of cancer research. Chapter One reviews the most recent advances in the management, analyses the best possible treatment in each scenario, and discusses the future research direction on brain metastases from non-small cell lung cancer. Chapter Two discusses the positive effects of microscopic complete resection on…
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Quick ViewThis book offers a comprehensive review on hepatocellular carcinoma (HCC) with a particular focus on the relationship between the pathobiology of disease and the clinical aspects including diagnosis and treatment. HCC is becoming one of the most common causes of cancer related death worldwide and is predicted to be the third leading cause of cancer…
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Quick ViewThe human life is considered most vital of all the living creatures on Earth because humans are bestowed with the highest level of cognition. One can enjoy life if the natural gift, the body, is in a good or healthy condition. A disease is an abnormal condition of the body resulting from infections, toxicity, unfavourable…
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Quick ViewCancer is a term that describes a constellation of diseases that affect a large proportion of the global population. By 2020, it is estimated there will be 15 million new cancer cases worldwide and a corresponding 12 million cancer-related deaths. There are many efficacious treatments for cancer with both curative and palliative intents, which regardless…
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Quick ViewCancer metastasis is one of the greatest challenges for our society and is responsible for over 90% of cancer-related deaths. Even in the 21st century, currently available therapies have very limited curative effects for metastatic cancers patients, where the five-year survival rate is only about 20%. Our society needs rapid, sensitive, and reliable cancer therapy…
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Quick ViewThis book presents original results on the leading edge of cancer research. Chapter One presents an overview of the opportunities and challenges that influence the participation of personalized approach of giving the right drug at the right dose to the right patient. Chapter Two examines malignant mesothelioma. Chapter Three reviews the role of heat-shock proteins…
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Quick ViewThis book introduces recent topics regarding carcinogenesis, including manifold findings of cell proliferation biology, abnormal cell division, pathophysiology, diagnosis, prevention and treatment implicated in the fields of cancer. Carcinogenesis is a multistep process initiated by external stimuli that lead to genetic changes in normal cells or stem cells, resulting in proliferation, apoptosis, dysplasia and neoplasia.…
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Quick ViewThis practical guide to the management of thyroid nodules and cancer offers the practitioner a common-sense approach to the management of an increasingly common clinical problem. Thyroid cancer is the most rapidly increasing cancer diagnosis in the United States and is now the fifth most common cancer among women. Indeed, an estimated 65,000 adults (15,000…
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