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Quick ViewObesity is a major risk for both cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Obesity has reached epidemic proportions globally, and evidence suggests that the situation is likely to get worse in both developed and developing countries. It is considered to be a predisposing factor for several chronic diseases which include CVD, ischemic…
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Quick ViewThis book raises very important issues that concern the severe hypercholesterolemia phenotype. The severe hypercholesterolemia phenotype such as familial hypercholesterolemia (FH) is characterised by increased plasma low density lipoprotein (LDL) cholesterol concentration above 190 mg/dl, regardless of the cause. The majority of patients with FH present mutations in genes controlling LDL concentration, such as genes…
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Quick ViewMucopolysaccharidoses (MPS) are caused by a deficiency of lysosomal enzyme activities needed to degrade glycosaminoglycans (GAGs), which are long unbranched polysaccharides consisting of repeating disaccharides. GAGs include: Chondroitin sulfate (CS), dermatan sulfate (DS), heparan sulfate (HS), keratan sulfate (KS), and hyaluronan. Their catabolism may be blocked singly or in combination depending on the specific enzyme…
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