The Sentinel Lymph Node: Detection, Procedures and Clinical Implications

Ambrogio Pietro Londero, M.D., Ph.D., Serena Bertozzi, M.D. and Carla Cedolini (Editors)
University Hospital of Udine, Italy

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

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The Sentinel Lymph Node: Detection, Procedures and Clinical Implications gathers an overview of the sentinel lymph node biopsy procedure among different surgical settings (i.e., melanoma, breast, thyroid, vulva, endometrium, cervix, colon, anus, liver, gastric, urological and ovarian cancers). This book consists of eighteen chapters; the rationale and the purpose of this technique, which allows adequate lymph node staging while sparing patients from unnecessary complete lymph node dissections and the traditional harmful complications associated with them are discussed.

Furthermore, this book outlines the technical aspects of the procedure (which are also accurately covered) from the various intraoperative sentinel node detection techniques to the subsequent sentinel lymph node analysis methods. Some new techniques for node detection, such as the Sentimag® technique (superparamagnetic iron oxide particles detected by a magneto-metric probe) and some new techniques for node analysis, such as the one-step nucleic acid amplification (OSNA), are accurately discussed. Finally, this book provides information also on preoperative lymph node diagnostics and sentinel lymph node biopsy perioperative complications in different nodal districts. In particular, the complications of sentinel node biopsy and for sentinel node dissection are accurately discussed with a particular focus on breast cancer, melanoma and gynecological cancers.

Preface

Chapter 1. Cancer Dissemination Pathways, Conservative Surgery, and the Rationale for Sentinel Lymph Node Biopsy
(Luca Seriau, Serena Bertozzi, Carla Cedolini and Ambrogio P. Londero, Breast Unit, University Hospital of Udine, Udine, Italy, and others)

Chapter 2. Sentinel Lymph Node Detection Technique
(Michela Andretta, Serena Bertozzi, Roberta Di Vora, Carla Cedolini, Ambrogio P. Londero, Breast Unit, DAME, University of Udine, University Hospital of Udine, Udine, Italy, and others)

Chapter 3. Technical Aspects of the Sentinel Lymph Node Evaluation
(Maria Orsaria, Serena Bertozzi, Stefania Marzinotto, Ambrogio P. Londero and Laura Mariuzzi, Institute of Pathology, DAME, University of Udine, University Hospital of
Udine, Udine, Italy, and others)

Chapter 4. Sentinel Lymph Node Biopsy in Breast Cancer
(Serena Bertozzi, Carla Cedolini and Ambrogio P. Londero, Breast Unit, DAME, University of Udine, University Hospital of Udine, Udine, Italy, and others)

Chapter 5. Breast Cancer Nodal Staging
(Luigi Viola, Ambrogio P. Londero, Serena Bertozzi and Gianluca Gatta, Radiology Department, University of Campania "Luigi Vanvitelli", Naples, Italy, and others)

Chapter 6. Sentinel Lymph Node Biopsy in Melanoma
(Roberta Di Vora, Carla Cedolini, Cinzia Bulligan, Fabrizio De Biasio, Pier Camillo Parodi, Serena Bertozzi, Breast Unit, DAME, University of Udine, University Hospital of Udine, Udine, Italy)

Chapter 7. Complications of the Sentinel Lymph Node Biopsy for Breast Cancer and Melanoma
(Carla Cedolini, Serena Bertozzi, Luca Seriau, Luigino Noce, Ambrogio P. Londero, Breast Unit, University Hospital of Udine, Udine, Italy, and others)

Chapter 8. Sentinel Lymph Node Biopsy in Thyroid Cancer
(Mattia Portinari and Paolo Carcoforo, Department of Surgery, S. Anna University Hospital of Ferrara, Ferrara, Italy, and others)

Chapter 9. Sentinel Lymph Node Biopsy in Vulvar Cancer
(Ambrogio P. Londero, Eva Wilhelmer, Serena Bertozzi, Arrigo Fruscalzo and Ralph J Lellé, Clinic of Obstetrics and Gynecology, University Hospital of Udine, Udine, Italy, and others)

Chapter 10. Sentinel Lymph Node Biopsy in Cervical Cancer
(Anna Biasioli, Giulia Trombetta, Ambrogio P. Londero and Angelo Cagnacci, Clinic of Obstetrics and Gynecology, DAME, University of Udine, University Hospital of Udine, Udine, Italy, and others)

Chapter 11. Sentinel Lymph Node Biopsy in Endometrial Cancer
(Monica Della Martina, Martina Venier, Ambrogio P. Londero and Angelo Cagnacci, Clinic of Obstetrics and Gynecology, DAME, University of Udine, University Hospital of Udine, Udine, Italy)

Chapter 12. Ultrasound Nodal Staging in Cervical and Endometrial Cancer
(Anjeza Xholli, Fabiana Cecchini, Ambrogio P. Londero and Angelo Cagnacci, Clinic of Obstetrics and Gynecology, DAME, University of Udine, University Hospital of Udine, Udine, Italy)

Chapter 13. Complications of Lymphadenectomy and Sentinel Lymph Node Biopsy in Patients with Gynecological Cancer
(Nicoletta Biglia, Valentina E. Bounous, Elisabetta Robba and Guido Menato, Academic Division of Obstetric and Gynacology, Mauriziano Umberto I Hospital, University of Turin, Turin, Italy, and others)

Chapter 14. Sentinel Lymph Node Biopsy in Anal Carcinoma
(Giovanni Terrosu, Carla Cedolini, Edoardo Scarpa, Ambrogio P. Londero and Serena Bertozzi, Clinic of Surgery, University Hospital of Udine, Udine, Italy, and others)

Chapter 15. Sentinel Lymph Node Biopsy in Colorectal Cancer
(Giovanni Terrosu, Edoardo Scarpa, Serena Bertozzi, Ambrogio P. Londero, Clinic of Surgery, University Hospital of Udine, Udine, Italy, and others)

Chapter 16. Liver Lymphatics, Sentinel Node Mapping and Possible Clinical Applications of Sentinel Lymph Node Biopsy in Liver Surgery
(Luca Roncati, Massimo Lupi, Chiara Cavatorta and Antonio Manenti, Departments of Pathology and Surgery, University Hospital of Modena, Modena, Italy)

Chapter 17. Less Common Applications of the Sentinel Lymph Node Biopsy
(Serena Bertozzi, Carla Cedolini,Luca Seriau, Roberta Di Vora, Ambrogio P. Londero and Andrea Risaliti, Breast Unit, Clinic of Surgery, DAME, University of Udine, Udine, Italy, and others)

Chapter 18. The Sentinel Lymph Node Biopsy from the Past to the Future
(Serena Bertozzi, Carla Cedolini and Ambrogio P. Londero, Breast Unit, DAME, University of Udine, University Hospital of Udine, Udine, Italy, and others)

Index

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