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The questions we ask in this book about cancer are actually quite elementary. What is the origin of cancer? Does cancer arise in any cell in the body, or only in certain cells? Is cancer a genetic or a stem-cell disease? We illustrate that cancer is a multicellular rather than a unicellular process, a cellular…
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In the opening chapter, authors discuss the current literature that describes the application of Palliative Medicine services in advanced cancer, models of Palliative Care delivery by site and mode of practice, cost-effectiveness of early Palliative Medicine referral patterns and national and international Palliative Medicine practice and referral guidelines. The chapter will also discuss the outcomes…
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In early stages of cancer, patients are often presented with treatment options and encouraged to have shared treatment decisions with their oncologists. Shared decision making becomes particularly important, as several treatment options with different possible outcomes and adverse events exist. For example, women with early breast cancer are counseled on the options of mastectomy versus…
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Many cancer patients experience a variety of distressing symptoms, adversely affecting their functional status and quality of life (QOL). Subjective symptoms such as pain, fatigue and depression are common among cancer patients, with approximately 33-55% of cancer patients experiencing pain during the course of their illness. Previous literature commonly examined a single symptom and its…
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As a leader in cutaneous oncology and a professor at the MD Anderson Cancer Center, senior editor Dr. Migden assembled a panel of authors with considerable expertise to participate in the writing of this book. Basal Cell Carcinoma: Advances in Research and Treatment provides the most comprehensive overview of evidence-based treatment approaches for the most…
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Several medical options in palliative care can have complex moral, religious, cultural, medical and legal issues. These treatment options, such as assisted suicide, rehydration, parenteral nutrition and cardiopulmonary resuscitation have been heavily debated in the literature. Physician-assisted suicide is a controversial topic for debate, with growing pressure from advocacy groups for legalization in regions that…
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Acute myeloid leukemia (AML) is an aggressive bone marrow cancer associated with high morbidity and mortality and most commonly affects older patient populations. In this book, the clinical presentation of acute myeloid leukemia are presented. Other chapters present the differences in the outcomes of two subtypes of core binding factor (CBF) acute myeloid leukemia (AML);…
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Ovarian cancer is the third most diagnosed gynecologic cancer and the first leading cause of death from all of gynecological malignancies. High mortality of the patients is usually associated with the progression of the disease. Most patients are diagnosed within the advanced stages due to lacking relevant diagnostic and screening markers. This handbook discusses several…
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Breanne Lechner, MD(C) is a clinical research assistant in the Rapid Response Radiotherapy Program at the Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Canada and also a medical student at the University of Toronto. She was the recipient of the J Frank Brookfield Scholarship from the University of Waterloo in 2012 for excellence in biology.…
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This book presents original results on the leading edge of cancer research. Lipomas are extremely common benign lesions, representing the most common softtissue tumor, with a wide spectrum of clinical presentations and imaging appearances. Several subtypes are described, ranging from lesions entirely composed of mature adipose tissue to tumors intimately associated with nonadipose tissue, to…
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Frontiers in Leukemia Pharmacotherapy provides a comprehensive overview of the various leukemic disorders found in both children and adults, with an emphasis on current and novel treatment approaches for the healthcare practitioner. By focusing on the unique therapeutic challenges of leukemia, this book aims to meet the diverse needs of physicians, pharmacists, nurses, and other…
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The book Psychoneurocybernetic Conquest of Carcinogenesis and Cancers is written to be understood by the informed layman as well as by scientists. It should be of special interest to physicians, health-care givers and laymen who want to know about the latest knowledge concerning the true cause of all cancers and their prevention, diagnosis and modern…
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This book presents original results on the leading edge of cancer research. Topics discussed include imaging of chondrosarcoma; novel nutrient mixtures inhibiting chondrosarcoma invasion and metastasis parameters; defective estrogen signaling is the highest risk for breast cancer; review of the cancer genomic landscape; reprogramming of metabolic pathways and cancer stem like cells; promising natural products…
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Cholangiocarcinoma is a heterogeneous group of neoplasms, which has a rising worldwide incidence. Therefore, it is now a major cause of cancer mortality. Diagnosis, staging, treatment approaches and outcomes differ significantly based on the location of the tumor. Given the challenges of remaining up-to-date in a rapidly expanding field, the aim of this monograph is…
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In Canada over the past fifteen years, there has been a 39% rise in new cancer patients, necessitating the expansion of current oncological facilities. The population is getting older and larger, which in turn is translating into more cases of cancer. Other reports projecting cancer growth across different countries found similar results. With the prevalence…
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HCC is the most common primary cancer of the liver and according to the WHO report, the fourth commonest cause of death. The estimated incidence of new cases worldwide is about 500,000-1,000,000 per year causing 600,000 deaths globally per year. Although there are large areas of the world where the incidence of HCC is still…
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Cancer is the second leading cause of morbidity and mortality worldwide, ranking just after cardiovascular diseases. In the central nervous system, gliomas constitute the most frequent type of tumors. According to the definition, oligodendrogliomas are diffusely infiltrating glial tumors, composed of neoplastic oligodendroglial cells, typically found in cerebral hemispheres in adult population, although not uncommon…
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The diagnosis and treatment of Diffuse large B-cell lymphoma (DLBCL) have evolved significantly in the past decade. With advances in our understanding of DLBCL through the application of immunophenotypic, molecular cytogenetic analysis and clinical correlation, a growing number of discrete subtypes and entities of DLBCL have been recognized, along with improved prognostic stratification and treatment…
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This book provides research on ependymomas, a rare brain tumor that arises from the ependymal cells of the intra-ventricular central nervous system (CNS) parenchyma with a propensity to affect both children and adults. Ependymomas account for only 1.9% of all primary brain and CNS tumors. Chapter One discusses the prognosis and outcomes in patients with…
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This book presents original results on the leading edge of cancer research. Chapter One explains unanswered questions of contemporary oncology from the standpoint of karyogamic theory of carcinogenesis. Chapter Two focuses on the molecular players of the human papillomaviruses (HPVs) infection leading to chronic inflammation and cancer. Chapter Three describes Multiple Myeloma (MM), and Monoclonal…
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Horizons in Cancer Research. Volume 71 begins by reviewing the histopathological features of head and neck squamous cell carcinoma and its precursor lesions, risk factors for head and neck squamous cell carcinoma including viral infection, chemical carcinogenic and ethnic predisposition. New knowledge about major pathways and signaling is also presented. Next, the clinical development of…
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The Easy Book of Cancer Pharmacology
Oncology, Pharmacology - Research, Safety Testing and Regulation, Cancer Etiology, Diagnosis and Treatments, Pharmacology, Medicine and Health$210.00Quick ViewThe Easy Book of Cancer Pharmacology represents the efforts of young oncologists, haematologists, pharmacists and oncology nurses who are highly motivated and encouraged by the significant development of new effective anticancer drugs. Since the discovery of antimetabolites and alkylating agents in the 1940s and 1950s, many new products have been introduced into our daily arsenal…
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Besides surgery, radiation therapy, endocrine therapy or chemotherapy, which were widely used in cancer patients for decades, the 21st century has seen the emergence of “targeted” therapy, resulting from the identification of molecular pathways in cells and their alterations in tumors. An increasing number of compounds targeting specific molecules or cancer cells have been developed…
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Primary bile duct cancers are rare and generally aggressive entities. Historically, this disease was managed exclusively with surgical therapy with few long-term survivors. However, with improvements in chemotherapeutics, targeted therapy, interventional radiology techniques and development of alternative surgical approaches, treatment has moved to the utilization of a multidisciplinary care team employing multimodality treatments which has…