Pharmaceutical Formulation and Medicinal Chemistry: Mechanisms, Developments and Treatments

$275.00

Bruce Moore (Editor)

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED071000

This book reviews research on pharmaceutical formulation and medicinal chemistry. It begins with a summary of old and new discoveries on therapeutic applications of the A3 adenosine receptor in inflammation and cancer, and highlights the most important agonists and antagonists developed for the A3 adenosine receptor, explicitly those in clinical trials for the treatment of inflammation and/or cancer.

The next chapter addresses and highlights the different inhibitions against metastases in vivo and molecular mechanisms of action in vitro of Biz compounds especially relating to the inhibitory efficacies against tumor metastasis and other important clinical utilizations including inhibitory pathways against angiogenesis, topoisomerase II, calmodulin, sialic acid, fibrinogen, drug combinations, medicinal chemistry, cell-movement and so on. Chapter three focuses on concepts of isosterism and bioisosterism in modern medicinal chemistry. The final chapter discusses the determination of L-Dopa in pharmaceutical formulations with a glassy carbon electrode (GCE) modified with cobalt phthalocyanine (CoPc) adsorbed on multi-walled carbon nanotubes (MWCN).
(Imprint: Nova)

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Table of Contents

Table of Contents

Preface
pp. vii-ix

Chapter 1
A3 Adenosine Receptor Ligands in the Treatment of Inflammation and Cancer
(Cheong Siew Lee, Federico Stephanie, Tan Boon Wu Aaron, Spalluto Giampiero and Pastorin Giorgia, Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia, and others)
pp. 1-72

Chapter 2
Antimetastatic Activities and Mechanisms of Action among Bisdioxopiperazine Compounds
(Da-Yong Lu, Jian Ding, Rui-Ting Chen, Bin Xu and Ting-Ren Lu, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, PR China, and others)
pp. 73-106

Chapter 3
Development of New Enzyme Inhibitors: Purine Bioisostere Perspective
(Felicia Phei Lin Lim, Anna V. Dolzhenko and Anton V. Dolzhenko, School of Pharmacy, Monash University Malaysia, School of Pharmacy, Curtin Health Innovation Research Institute, Curtin University, Australia)
pp. 107-130

Chapter 4
L-Dopa Determination Employing an Electrochemical Sensor based on Carbon Nanotube Modified with Cobalt Phthalocyanine
(Ana Elisa Ferreira de Oliveira and Arnaldo César Pereira, Universidade Federal de São João del-Rei (UFSJ), Departamento de Ciências Naturais, São João del-Rei, MG, Brazil)
pp. 131-144

Index
pp. 145-155

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