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Quick ViewCurrently, used anticancer drugs are found to be poorly water soluble and highly potent in nature. They act non-selectively on both tumor as well as normal cells. This non-selectivity is being tried to overcome by means of selective or targeted tumor drug delivery with improvised safety and efficacy. This book discusses nanocarrier systems for drug…
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Quick ViewOver the past few decades, a number of legislative actions have been taken to encourage the development of therapies to treat people affected by rare diseases and to encourage therapies for pediatric patients. During this same time period, the Food and Drug Administration (FDA) has invested substantial effort in support of these same goals. As…
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Quick ViewThe book Advances in Studies on Enzyme Inhibitors as Drugs edited by eminent scientist Satya P. Gupta, covers the most recent development on design and discovery of the most useful drugs acting against several life threatening diseases such as cancer, viral infections and many others in two volumes. All of these drugs are based on…
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Quick ViewThe book Advances in Studies on Enzyme Inhibitors as Drugs edited by eminent scientist Satya P. Gupta, covers the most recent development on design and discovery of the most useful drugs acting against several life threatening diseases such as cancer, viral infections and many others in two volumes. All of these drugs are based on…
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Quick ViewDepression is a common worldwide mental illness, and one of the leading causes of disability. It is not exclusive for an age, social or income level. Antidepressants are used as a pharmacological treatment for depression. Currently available antidepressants have several limitations including a long time lag for treatment response, modest rates of efficacy and the…
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Quick ViewThis book is a compilation of most works published during 2000-2016 in the area of dry powder inhalers, especially related to the issues with formulation and device design. The dry powder inhalers aim to deliver the medication to the respiratory airways. It is suitable for postgraduate students and researchers who work in the areas of…
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Quick ViewWorldwide, adverse drug reactions are a major cause of morbidity and mortality in patients, as well as increased healthcare costs. Published data show that there are around 2 million adverse drug reactions, including 100,000 deaths, which are established as the fourth leading cause of mortality. This culminates an estimated cost of 136 billion dollars to…
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Quick ViewNonsteroidal anti-inflammatory drugs (NSAID’s) are one of the most widely prescribed drugs for their analgesic, anti-inflammatory and antipyretic properties. This book provides new research on the common uses, risks and effectiveness of NSAIDs. Chapter One evaluates the potential environmental health impacts of NSAIDs in aquatic environments. Chapter Two reviews the incidence rate and toxic damage…
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Quick ViewBy the nature of its use, the intrathecal baclofen pump is frequently implanted in children and adults with either an advanced spinal, pelvic or hip deformity who suffer from muscle spasticity. These deformities often lead to additional surgical procedures either simultaneously or after the implantation of the baclofen pump and intrathecal catheterization. In the first…
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Quick ViewCarbamazepine (CBZ) is a member of the iminostilbene family, and it possesses a carbonyl group that is essential for its antiepileptic activity. It has been demonstrated and is widely accepted that CBZ is effective in the control of epileptic crises; unfortunately, there is scattered information concerning whether CBZ can aid in the sleep disorders produced…
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Quick ViewConsumers’ Guide to Prescription and Over the Counter Medications is a comprehensive reference guide for consumers to refer to when questions about their or their loved ones diseases or medications arise. The book is organized based on common disease states via different body systems: Cardiovascular disorders (high blood pressure, heart failure, heart rhythm problems); respiratory…
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Quick ViewPain and itch are associated with a wide range of injuries and diseases. Some conditions may have pain and associated symptoms arising from a discrete cause, such as postoperative and neuropathic pains or headaches. Chronic itch or pruritus is a frequent symptom in the general population and in many skin and systemic diseases. Millions of…
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Quick ViewHuman serum albumin is found in the intravascular and extracellular space and is the main protein of human blood plasma which binds water, cations (such as Ca2+, Na+, K+), fatty acids, hormones, bilirubin, thyroxin (T4) and pharmaceuticals. Structurally, the serum albumins are similar, each domain containing five or six internal disulfide bonds. In the opening…
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Quick ViewGlutathione (GSH) is a ubiquitous tripeptide (γ-L-gluatamyl-Lcysteinyl-glycin) playing an important role in cellular redox homeostasis, defence against electrophilyc reactive species, and control of several cellular events, among others. Most of these cellular functions are related to its tiol (SH) function of the cysteine moiety. With increasing knowledge on the molecular basis of its cellular functions,…
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Quick ViewHaloperidol is the most common neuroleptic drugs associated with a range of side effects caused by interactions with other drugs. In The Pharmacological Guide to Haloperidol, the authors review cases that report common pharmacodynamic and pharmacokinetic drug interactions of haloperidol in vivo. Next, this compilation investigates methods for the determination of haloperidol in body fluids…
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Quick ViewThe class of serotonin and noradrenaline reuptake inhibitors (or SNRIs) were introduced into clinical use as a result of the perceived short-comings of other antidepressant medications. Considerations of efficacy, side effects and tolerability have consistently indicated that there is a clinical need for agents demonstrating improvements in one or more of these domains. Since its…
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Quick ViewDoxycycline: Medical Uses and Effects opens with a personal account of experiments suggesting that doxycycline may play an important role in the fight against cancer and T-cell proliferation-related diseases. Additionally, retrospective clinical observations have revealed that doxycycline increases the life expectancy of patients with throat cancer. Doxycycline also possessing immune modulating and anti-inflammatory properties, thus…
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Quick ViewThis book is one of the most important books in this area because it is devoted to special characteristics of an important antibiotic (Ciprofluoxacin). It presents the new ways to enhance the bioavailability of ciprofluoxacin in the human body to increase its efficacy in disease treatments, such as preparation of solid forms of ciprofluoxacin, including…
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Quick ViewTyrosine kinase inhibitors are used to treat patients with advanced thyroid cancers. Sunitinib (SU11248) is an oral small-molecule, oxindol derivative, multi-targeted tyrosine kinase inhibitor that inhibits receptors for platelet-derived growth factor and vascular endothelial growth factor receptors, growth factor receptor, fms-related tyrosine kinase 3, RET oncogene and a multitargeted tyrosine-kinases. In Sunitinib: Mechanisms, Interactions and…
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Quick ViewIn the late 1950s, Sir James Black made a tremendous contribution to pharmacology and medicine with his discovery of β-blockers. After the first β-blockers became available in the 1960s, these drugs were noted to have beneficial effects in reducing morbidity and mortality from ischemic heart disease. It soon thereafter became apparent that blocking the adverse…
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