Table of Contents

Preface

Chapter 1. The Global Prevalence of Histoplasmosis
Ladan Panahi¹, Niraj Patel¹, Jessica Kaestner¹, Ella Lorng¹, Roxana Merino¹, Jessica Milligan¹, Ricco Rizo¹, Augusta Udeani¹, Salim Surani² and Laura Vasquez^1
1Department of Pharmacy Practice, Texas A&M Rangel School of Pharmacy, Texas, USA
²Clinical Professor, Texas A&M University, Texas, USA

Chapter 2. The Incidences and Prevalence of Histoplasmosis
Maryam Ahmed¹, Zara Borkowski², Sneha Reddy³, Reena Shah⁴ and Salim Surani^4,5, MD
¹ Department of Medicine, Punjab Medical College, Faisalabad, Pakistan
²Premedicine department, Incarnate Word Academy, Corpus Christi, Texas, USA
³Premedicine Department, University of Texas, Austin, Texas, USA
⁴Department of Medicine, Aga Khan University, Nairobi, Kenya
⁵Clinical Professor, Texas A&M University, Texas, USA

Chapter 3. Clinical Features of Histoplasmosis
Ayushi Mendiratta¹, MD, Piyush Garg², MBBS, Rahul Kashyap³, MD, and Salim Surani⁴, MD
¹PGY1 Resident, Internal Medicine, Parkview health system, Pueblo, Colorado, USA
²Department of Medicine, Heart Institute, Medanta- The Medicity, Gurgaon, Haryana, India
³Department of Research, Wellspan Health, York, USA
⁴Clinical Professor, Texas A&M University, Texas, USA

Chapter 4. Advances in the Diagnosis of Histoplasmosis: An Update into the Laboratory Diagnosis of Histoplasma capsulatum
M. A. Toscanini^1,2, C. Rodriguez Laboccetta^1,2, A. Videla Garrido², V. Briceño Fernández^1,2, K. Hermida Alava², A. Etchecopaz², C. A. Iovannitti², A. D. Nusblat¹ and M. L. Cuestas^2
1Department of Microbiology, Faculty of Medicine, Universidad de Buenos Aires, CONICET, Instituto de Nanobiotecnología (NANOBIOTEC), Cátedra de Biotecnología, Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina
²Department of Microbiology, Faculty of Medicine, Universidad de Buenos Aires, CONICET, Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM), Departamento de Microbiología, Facultad de Medicina, Buenos Aires, Argentina

Chapter 5. Radiological Findings in Histoplasmosis
Mikael Mir¹, BA, Taylor Benedict¹, BS, Sydney Boike¹, BS, Noura Attallah², MD, Jessica Sheehy³, PA, Eric Gomez Urena³, MD, and Syed Anjum Khan², MD
¹Department of Medicine; University of Minnesota Medical School, Minneapolis, Minnesota, USA
²Critical Care Medicine, Mayo Clinic Health System, Mankato, Minnesota, USA
³Department of Infectious Disease, Mayo Clinic Health System, Mankato, Minnesota, USA

Chapter 6. The Histopathology of Histoplasma
Gude Geethanjali¹, Lisa Centeno², Lia Nandi³, Namratha Seetharam Meda⁴, Karuna Bista⁵, Esraa Hassan⁶, Mool Chand⁶ , Aishwarya Reddy Korsapati⁷, Shika M Jain⁸, Sydney Boike⁹, Hasnain Saifee Bawaadam¹⁰, Syed Anjum Khan⁶,  Nitesh Kumar Jain⁶ and Sri J. Obulareddy
¹Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
²Department of Medicine; University of Santo Tomas Faculty of Medicine and Surgery,Manila, Philippines
³Department of Medicine; Kasturba Medical College, Manipal, India
⁴Department of Medicine; MedStar Washington Hospital Center, NW, Washington, D.C.,  USA
⁵Department of Medicine; Nepal Medical College, Kathmandu, Nepal
⁶Department of Hospital Medicine, Mayo Clinic Health System, Mankato, Minnesota, USA
⁷Department of Medicine, University of Buckingham Medical School, Buckingham, UK
⁸Department of Medicine, MVJ Medical College and Research Hospital, Karnataka, India
⁹Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
¹⁰Department of Pulmonary & Critical Care Medicine, Aurora Medical Center, Kenosha, Wisconsin, USA
¹¹Department of Oncology and Hematology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Chapter 7. Pulmonary Complications of Histoplasmosis
Rohan Kumar Ochani¹,  Hafsa Nazir Jatoi²,  Asim Shaikh³,  Iqbal Ratnani⁴ and Salim Surani^5
1Department of Internal Medicine, SUNY Upstate Medical University, Syracuse, New York, USA
²Department of Internal Medicine, Dow University of Health Sciences, Karachi, Pakistan
³Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
⁴Department of Anesthesiology and Critical Care, Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, Texas USA
⁵Clinical Professor, Texas A&M University, Texas, USA

Chapter 8. Gastrointestinal Manifestations in Histoplasmosis
Gowthami Sai Kogilathota Jagirdhar¹, Andres Perez², Syed Anjum Khan³ and Salim Surani^4
1Department of Medicine, Saint Michael’s Medical Center, Newark, New Jersey, USA
²Department of Medicine, Saint Francis health system, Tulsa, Oklahoma, USA
³Department of Critical Care, Mayo Clinic Health System, Mankato, Minnesota, USA
⁴Clinical Professor, Texas A&M University, Texas, USA

Chapter 9. Histoplasmosis in Human Immunodeficiency Virus Patients
Divya E. Abraham¹, Sajiny John², Salim Surani^3,4, Reena Shah⁵ and Rahul Kashyap^1,4,6
1Department of Research, GCSRT, Harvard Medical School, Postgraduate Medical Education, Boston, Masssachussetts, USA
²Clinical Research Coordinator, Department of Cardiology, Icahn School of Medicine, Mount Sinai, New York, USA
³Clinical Professor, Texas A&M University, Texas, USA
⁴Department of Anesthesiology and Critical Care, Mayo Clinic, Rochester, Minnesota, USA
⁵Department of Medicine, Aga Khan University Hospital, Nairobi, Kenya
⁶Department of Research, York Hospital, WellSpan Health, York, Pennsylvania, USA

Chapter 10. Histoplasma Capsulatum Endocarditis
Anwar Khedr¹, Aalaa Eissa², Hussam Hennawi³, Mikael Mir⁴, Shika M Jain⁵, Aishwarya R Korsapati⁶, Swechchha Silwal⁷, Ibtisam Rauf⁸, Nitesh Jain⁹ and Syed Anjum Khan ^9
1Department of Internal Medicine, BronxCare Health System, Bronx, New York, USA
²Department of Internal Medicine, KFS University, KFS, Egypt
³Department of Internal Medicine, Abington Memorial Hospital, Abington, Pennsylvania, USA
⁴Department of Medicine, University of Minnesota Medical school, Minneapolis, Minnesota, USA
⁵Department of Medicine, MVJ medical college and research hospital, Bengaluru, India
⁶Department of Medicine, University of Buckingham medical school, UK
⁷Department of Internal Medicine Wayne state University, Detroit, Michigan, USA
⁸Department of Medicine, St. George’s University Medical school, True Blue, Grenada
⁹Department of Critical Care, Mayo Clinic Health System, Mankato, Minnesota, USA

Chapter 11. Occupational Histoplasmosis
Maryam Ahmed¹, Lokesh Goyal², Deborat Mallick², Munish Sharma³ and Salim Surani^4
1Department of Medicine, Punjab Medical College, Faisalabad, Pakistan
²Department of Medicine, Christus Spohn Hospital- Corpus Christi, Texas, USA
³Department of Medicine, Baylor Scott & White, Temple, Texas, USA
⁴Clinical Professor, Texas A&M University, Texas, USA

Chapter 12. Neuro-Histoplasmosis
Simmy Lahori¹, Tanya Amal², Gaurang Bhatt³, Ruman Khurshid⁴, Rahul Kashyap⁵ and Salim Surani^6
1Department of Anesthesiology, Research Scholar, Mayo Clinic, Department of Radiology, Rochester, Minnesota, United States of America
²Department of Medicine, Maulana Azad Medical College, New Delhi, India
³Department of Medicine, Junior Resident, Department of Burns and Plastic Surgery, All India Institute of Medical Sciences, Rishikesh, India
⁴Department of Medicine, Sher-i -Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
⁵Department of Research, WellSpan Health, York, Pennsylvania, USA; Department of Anesthesiology and Critical Care Medicine, Rochester, Minnesota, United States of America; Harvard Medical School, Boston, Massachusetts, United States of America
⁶Clinical Professor, Texas A&M University, Texas, USA

Chapter 13. Disseminated Histoplasmosis
Akshat Banga¹, Riecha Joshi², Rahul Kashyap³, Reena Shah⁴ and Salim Surani^4,5
1Department of Medicine, Sawai Man Singh Medical College, Jaipur, India
²Department of Medicine, Government Medical College, Kota, India
³Department of Research, WellSpan Health, York, Pennsylvania, USA
⁴Department of Medicine, Aga Khan University Hospital, Nairobi, Kenya
⁵Clinical Professor, Texas A&M University, Texas, USA

Chapter 14. Pharmacological Management of Histoplasmosis
Ladan Panahi, Niraj Patel, Augusta Udeani, Ricardo Ibarra, Kasey Torres, Meina Determan, Perfecto Rodriguez IV, Phoung Tran, Salim Surani and Chinonso Paul
Department of Pharmacy Practice, Texas A&M Rangel School of Pharmacy and Reynolds Medical Building, College Station, Kingsville, Texas, USA

Chapter 15. Histoplasmosis in Pregnancy
Simmy Lahori¹, Rahul Kashyap^2,3 and Salim Surani^4,5
1Visiting Research Fellow, Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA
²Department of Research, WellSpan Health, York, Pennsylvania, USA
³Department of Anesthesiology and Critical Care Medicine, Rochester, Minnesota, USA
⁴Clinical Professor, Texas A&M University, Texas, USA
⁵Research Collaborator, Department of Anaesthesiology, Mayo Clinic, Rochester,Minnesota, USA

Chapter 16. Differential Diagnosis of Histoplasmosis
John Paul Aparece¹, Sung Whoy², Wailea Faye³, Gude Geethanjali⁴, Lisa Centeno⁵, Shika M Jain⁶, Sydney Boike⁷, Hasnain Saifee Bawaadam⁸, Sindu Mukesh⁹, Ibtisam Rauf¹⁰, Claudia Castillo Zambrano¹¹, Mohamad El Labban¹², Aysun Tekin¹³, Salim Surani¹⁴ and Nitesh Kumar Jain^15
1Department of Medicine, Texas Tech University El Paso, Texas, USA
²Department of Medicine, Cha Cebu Institute of Medicine, Philippines
³Department of Medicine, Salva Cebu Institute of Medicine, Philippines
⁴Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
⁵Department of medicine, University of Santo Tomas Faculty of Medicine and Surgery, Manila, Philippines
⁶Department of Medicine, MVJ Medical College and Research Hospital, Karnataka, India
⁷Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
⁸Department of Pulmonary & Critical Care Medicine, Aurora Medical Center, Kenosha, Wisconsin, USA
⁹Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
¹⁰Department of Medicine, St. George’s University School of Medicine, St. George, Grenada
¹¹Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
¹²Department of Internal Medicine, Mayo Clinic Health System, Mankato, Minnesota, USA
¹³Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
¹⁴Clinical Professor, Texas A&M University, Texas, USA
¹⁵Department of Critical Care Medicine, Mayo Clinic Health System, Mankato, Minnesota, USA

Chapter 17. Histoplasmosis-Induced Hemophagocytic Syndrome
Noura Attallah¹, Ibtisam Rauf², Abbas B. Jama¹, Esraa Hassan¹, Syed Anjum Khan¹ and Mohamad El Labban^3
1Critical Care Medicine Department, Mayo Clinic Health System, Mankato, Minnesota, USA
²Medicine Department, St. George’s School of Medicine, University Centre Grenada, West Indies, Grenada, USA
³Internal Medicine Department, Mayo Clinic Health System, Mankato, Minnesota, USA

Index