Recent Trends in Gene Expression


Subhrangsu S. Mandal, PhD (Editor)
Department of Chemistry and Biochemistry, C.P.B. The University of Texas at Arlington, Arlington, TX, USA

Series: Genetics – Research and Issues
BISAC: SCI029000

The term “Gene†  refers to a segment of DNA present inside the genome that code for a protein. Depending on the organism, a particular genome may encode thousands of diverse types of genes responsible for various functions. These genes are differentially expressed and tightly regulated as needed at different stages of cell and physiological functions including cell differentiation and development. Gene expression may be influenced by various environmental and stimuli such as temperature, nutrients, hormones, stress etc.

Though the fundamental mechanism of transcription (production of mRNA from the protein coding genes) is very similar in different organisms, the mechanism of gene regulation and the machineries involved are distinct for different organisms. In the post genomic and epigenomic era, it is increasingly being recognized that gene expression is not only controlled gene sequences but also various other non-genomic factors that include protein and DNA modifications and non-coding RNAs. Various aspects of gene expression in prokaryotes and eukaryotes, the mechanism of transcription and gene regulation and influences of various environmental factors are highlighted in different chapters of this book. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Chapter 1 – Mechanism of Transcription in Prokaryotes
(Runa Sur and Jayanta Mukhopadhyay, Department of Chemistry
Bose Institute, Kolkata, India, and others)

Chapter 2 – How Noisy is RNA Production in Escherichia Coli When Seen in Vivo, One Event at a Time
(Andre S. Ribeiro, Laboratory of Biosystem Dynamics, Computational Systems Biology Research Group, Department of Signal Processing, Tampere University of Technology, Finland)

Chapter 3 – The Biochemistry of F 420 Cofactor Biosynthesis (Tijani Osumah, Cuong Q. Le, Tony D. Nguyen, and Kayunta Johnson-Winters, Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX, USA)

Chapter 4 – Regulation of Gene Expression through mRNA Stability: Implications in Cancer Development and Therapeutics
(Rania Indu, Alina Chakraborty, Sumita Sengupta and Tapas K. Sengupta, Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, India, and others)

Chapter 5- Roles of Small RNAs in Regulation of Signaling and Adaptive Responses in Plants
(Shree P. Pandey, Taraka Ramji Moturu and Priyanka Pandey, Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, West Bengal, India, and others)

Chapter 6 – Nuclear Organization of Cancer Cells
(Devika Ranade and Kundan Sengupta, Chromosome Biology Laboratory
Indian Institute of Science Education and Research, Pune, India)

Chapter 7 – Insect Lipid Metabolism: Insights into Gene Expression Regulation
(David Majerowicz and Katia C. Gondim, Instituto de Bioquímica Médica, Programa de Biologia Molecular e Biotecnologia, Universidade Federal do Rio de Janeiro, Brazil, and others)
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Chapter 8 – Blood Based Gene Expression: Useful Biomarkers for Alzheimer’s and Parkinson’s Diseases
(Anders Lönneborg, Line Røed and Magnus Sjögren, DiaGenic, Oslo, Norway)
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Chapter 9 – Microarray-Based Whole Transcriptome Expression Profiling as a Tool to Understand Human Ageing
(A.D. Fellows, A.C. Holly, L.C. Pilling, D. Melzer and L.W. Harries, Institute of Biomedical and Clinical Sciences, Exeter Medical School, University of Exeter, Exeter EX, LU, UK, and others)

Chapter 10 – Lessons from the Gene Expression Studies of Immunocompetent Cells in Relationship to Type 1 Diabetes Development
(K. Stechova, M. Kolar and D. Filipp, Department of Paediatrics, 2nd Medical Faculty of Charles University and University Hospital Motol, Prague, Czech Republic, and others)

Chapter 11 – Current Technologies for Assessing Epigenetic Marks and their Utilization in the Study of Metal Carcinogenesis
(Adriana Arita and Max Costa, New York University School of Medicine, Nelson Institute of Environmental Medicine, NY, USA, and others)

Chapter 12 – Chromium(III): Bio-Significant or Bio-Toxic?
(H. Yamini Shrivastava, V.G. Vaidyanathan and Balachandran Unni Nair, Chemical Laboratory, Central Leather Research Institute, Council of Scientific and Industrial Research, Chennai, India)

Chapter 13 – RMP: From Transcription to Oncogenesis
(Shaomu Chen and Wenxiang Wei, Department of Cell Biology, School of Medicine, Suzhou University, Suzhou, China)


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