Precision Medicine: Where are We and Where are We Going?

$310.00

Rina Kansal, M.D. – The University at Buffalo, Buffalo, New York, USA; Associate Medical Director, Molecular Oncology and Genetics, Diagnostic Laboratories, Blood Center of Wisconsin, USA

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED024000; MED067000; MED062000
DOI: https://doi.org/10.52305/WQEQ5178

The book is written and edited by an individual fortunate to see and work through the evolution of precision medicine in the last three decades with contributions from experts in their respective fields. The book begins with an introduction to genomics and precision medicine, followed by a chapter on pediatric genomic sequencing and nine chapters focused on the pathologic diagnosis required for precision therapies in cancer. Tumors of the central nervous system (the brain and spinal cord) and the thyroid and salivary glands are described, including the most up-to-date World Health Organization (WHO) diagnostic pathologic classifications. The importance of the WHO classification of cancer in precision medicine is discussed. For hematolymphoid neoplasms, a detailed historical background for leukemia and lymphoma classifications precedes the description of the 5th edition WHO 2022 classification and its comparison with the International Consensus Classification. Novel techniques in flow cytometry and measurable residual disease detection in hematolymphoid neoplasms by flow cytometry are described with ample illustrations. Other chapters include liquid biopsies in blood cancer, precision diagnosis in the lung, colorectal, ovarian, and prostate cancers, novel immunotherapies in cancer, including essential concepts underlying pathologic testing in cancer, and digital pathology and artificial intelligence as necessary tools for advancing precision medicine.

Table of Contents

Preface

Chapter 1. An Introduction to Genomics and Precision Medicine
Rina Kansal, MD
The University at Buffalo, Buffalo, New York, USA

Chapter 2. Pediatric Genomic Medicine
Erica Sanford Kobayashi, MD
Rady Children’s Institute for Genomic Medicine, San Diego, CA, USA Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, USA

Chapter 3. Tumors of the Central Nervous System
Lisa M. Arnold, DO¹, Erin D’Agostino, MD², Alissa A. Thomas, MD³, and John C. DeWitt, MD, PhD⁴
¹Intermountain Healthcare, Department of Medical Oncology, Murray, UT , USA
²PGY4 Resident, Department of Neurosurgery, University of Vermont Medical Center, Burlington, VT USA
³Associate Professor, Department of Neurological Sciences, University of Vermont Medical Center, Burlington, VT USA
⁴Assistant Professor, Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT 05401, USA

Chapter 4. Salivary Gland Neoplasms
Ernesto M. Duarte, MD, Brian D. Stewart, MD, and Marino E. Leon, MD
Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA

Chapter 5. Thyroid Gland Neoplasms
Doreen N. Palsgrove¹, Ernesto M. Duarte², Marino E. Leon² and F. Zahra Aly²
¹Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA
²Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA

Chapter 6. Novel Immunotherapies in Hematologic and Non- Hematologic Cancers
Rina Kansal, MD
The University at Buffalo, Buffalo, New York, USA

Chapter 7. Selected Topics for Precision Diagnosis in Lung, Gastrointestinal, Gynecological, and Male Genitourinary Cancers Rina Kansal, MD
The University at Buffalo, Buffalo, New York, USA

Chapter 8. The World Health Organization (WHO) Classification of Tumors with Emphasis on the Classification of Hematolymphoid Neoplasms
Rina Kansal, MD
The University at Buffalo, Buffalo, New York, USA

Chapter 9. Flow Cytometry for Hematopoietic and Lymphoid Neoplasms
You-Wen Qian, Paul Wallace, Orla Maguire, and Hans Minderman
Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA

Chapter 10. Liquid Biopsy in Blood Cancer
Jun K. Lim¹, Bryone Kuss², and Dipti Talaulikar¹,³
¹Department of Haematology, ACT Pathology, Canberra Health Services, Canberra, ACT, Australia
²Department of Molecular Medicine and Genetics, Flinders University/Flinders Medical Centre, SA, Australia, Pathology Laboratories, Adelaide, SA, Australia
³College of Health and Medicine, Australian National University, Canberra, ACT, Australia

Chapter 11. Digital Pathology and Precision Medicine
Kenji Ikemura, MD, Takashi Ohnishi, PhD, and Yukako Yagi, PhD
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Index


Editor’s ORCID iD

Rina Kansal 0000-0003-4289-3057

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