New Research on Hematological Malignancies

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David K. Gioia (Editor)

Series: Cancer Etiology, Diagnosis and Treatments

BISAC: MED062000

Hematological malignancies, defined as cancers that affect the blood, bone marrow, and lymph nodes, represent a serious health care challenge for oncologists. Chapter One focuses on cytogenetic and molecular markers and summarizes their importance in identification, treatment and prognosis in patients with myeloproliferative neoplasms. Chapter Two details the efficacy of treatment of myeloid hematologic malignancies with isocitrate dehydrogenase mutations by inhibitors of this enzyme. Chapter Three describes the use of Selinexor and other drugs for the treatment of hematologic malignancies. Chapter Four explains the utility of poly(ADP-ribose) polymerase inhibitors in the treatment of myelodysplastic syndrome and acute myeloid leukemia.

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Preface

Chapter 1. Molecular and Cytogenetic Markers and Their Clinical Implications in Myeloproliferative Neoplasms
(Seda Ekizoglu and Onur Baykara – Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Medical Biology, Istanbul, Turkey)

Chapter 2. Treatment of Myeloid Hematologic Malignancies with Isocitrate Dehydrogenase Mutations by Inhibitors of This Enzyme
(Ota Fuchs – Institute of Hematology and Blood Transfusion, Prague, Czech Republic)

Chapter 3. Inhibition of Nuclear Export as a New Therapy in Hematologic Malignancies
(Ota Fuchs – Institute of Hematology and Blood Transfusion, Prague, Czech Republic)

Chapter 4. Poly(adp-Ribose) Polymerase Inhibitors in the Treatment of Myelodysplastic Syndrome and Acute Myeloid Leukemia
(Ota Fuchs – Institute of Hematology and Blood Transfusion, Prague, Czech Republic)

Index

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