Male and Female Infertility: Genetic Causes, Hormonal Treatments and Health Effects


Editors: Björn Glantz and Klas Edquist
Series: Human Reproductive System – Anatomy, Roles and Disorders

Infertility is a major increasing concern. As the male factor contributes to about half of the infertility cases, sperm analysis is extremely important for diagnosis and investigation of infertility. In this book, the cytometric techniques used to evaluate sperm DNA/chromatin integrity together with some other functional properties of the male gamete are described and advantages and limitations are discussed. In addition, the authors provide an overview of how antioxidative and redox systems participate in spermatogenesis and in pathological conditions, such as heat stress, in the testes. Oxidative stress-induced damage to both oocytes in vivo and embryos in culture are also examined, as well as the role of ROS signaling in embryo development. Furthermore, endometriosis is an estrogen-dependent disease which affects 6% to 30% of women in reproductive age and is associated with infertility in approximately 60% of cases. In this book, classic and recently proposed etiopathogenic mechanisms or endometriosis-related infertility are discussed, as well as some aspects of its clinical investigation and medical treatment. Other chapters in this book assess the capability of combining of Anti-Mullerian hormone (AMH) and embryo quality as predictors of pregnancy outcome and an examination of how the use of animal models can help us to understand the female reproductive system and the etiology of some female infertile disorders.

Table of Contents


Flow Cytometric Analyses of Sperm Functions and Genetic Integrity
(Helena Oliveira, Marcello Spanò, Conceição Santos, Maria de Lourdes Pereira, Department of Biology, CICECO, University of Aveiro, Aveiro, Portugal)pp.1-32

Requirement of Multiple Antioxidative/Redox Systems to Support Male Fertility
(Junichi Fujii, Yoshihito Iuchi, Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata, Japan) pp.33-54

Active Oxygen Species as a Signal of Embryonic Developmental Arrest and Death
(Naoko Kimura, Junichi Fujii, Laboratory of Animal Reproduction, Faculty of Agricultural Sciences, Yamagata University, Tsuruoka, Japan, and others)pp.55-76

Endometriosis-Related Infertility: Etiopathogeny, Clinical Aspects and Non-Surgical Approach (Bruno Ramalho de Carvalho, Genesis – Centre for Assistance in Human Reproduction, Brasília, Distrito Federal, Brazil)pp.77-94

Developments in the Debate on Assisted Reproduction: A Gender Perspective (Manuela Perrotta, Department of Sociology and Social Research, University of Trento, Trento, Italy pp.95-112

Animal Models for Studying Female Infertility
(Paloma Sánchez-Aparicio, Clínica de Medicina de la Reproducción y Ginecología, FivMadrid, Madrid, Spain)pp.113-128

The Fallopian Tube Involvement in the Reproductive Process
(Sergio Ghersevich, Laboratory of Reproductive Studies, School of Biochemical and Pharmaceutical Sciences, National University of Rosario, Rosario, Argentina)pp.129-144

The Relevance of Serum Anti-Müllerian Hormone Levels, Chronological Age and Embryo Quality to the Outcome of Assisted Reproduction Technology Cycles (Tsung-Hsien Lee, Maw-Sheng Lee, Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan, and others)pp.145-157

Evidence for Decline in Male Infertility with Increasing Age: Effect on Spermatogenesis and Genetic Package
(Fabio F. Pasqualotto, Eleonora B. Pasqualotto, University of Caxias do Sul, RS, Brazil, and others)pp.159-171

Gene Therapy for Male Infertility: Potential and Limitation
(Yoshiyuki Kojima, Kentaro Mizuno, Shoichi Sasaki, Yutaro Hayashi, Kenjiro Kohri, Dept. of Nephro-Urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan)pp173-194

Index pp.195-214

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