Genotoxicity: Advances in Research and Applications


Chibuisi Gideon Alimba, PhD – Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria

Series: Chemistry Research and Applications
BISAC: SCI013090

The Induction of genotoxic effects on prokaryote and eukaryotes’ genetic materials is a crucial step in the initiation of cancer and genotoxic disease syndromes. Cancer risk assessment and other genetic disease syndromes required the application of genotoxicity biomarkers. Several genotoxicity assays have been developed and applied to assess the potentials for xenobiotics to induce DNA damage. In the edited book: “Genotoxicity: Advances in Research and Applications”, the applications of genotoxicity biomarkers were used to monitor heat-induced genotoxic agents in the reproductive system. Genotoxicity assays were applied in the assessment of genomic instability induced by environmental xenobiotics (including cement dust and pesticides) that humans and biota are exposed to in occupational settings and the environment. Advances in the application of genotoxicity include the use of in silico techniques to predict the genotoxic potentials of xenobiotics including pharmaceuticals which are increasingly being accumulated in the environment. Renounced authors in the field of genotoxicity have made comprehensive contributions to achieve the quality of the book contents.

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Table of Contents


Chapter 1. The Genotoxic Effects of Heat-Induced Food Contaminants in the Male Reproductive System
Banu Orta-Yilmaz1, Hatice Kurtel2, Burcu Keskin2 and Yasemin Aydin1
Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey
2Institute of Graduate Studies in Science and Engineering, Istanbul University, Istanbul, Turkey

Chapter 2. The Use of In Silico Models in the Prediction of Genotoxicity Potentials of Pharmaceuticals
Jülide Secerli1, Sevde Altuntas2,3, Onur Erdem1 and Merve Bacanli1
 1Gülhane Faculty of Pharmacy Department of Pharmaceutical Toxicology, University of Health Sciences Turkey, Ankara, Turkey
2Department of Tissue Engineering, Institution of Health Sciences, University of Health Sciences Turkey, Uskudar, Istanbul, Turkey
3Experimental Medicine Research and Application Center, University of Health Sciences Turkey, Uskudar, Istanbul, Turkey

Chapter 3. In Vitro and In Vivo Applications of Genotoxicity Biomarkers in the Assessment of Pesticides
Opeoluwa Ogunsuyi, Khalid Adekoya, Adebayo Ogunkanmi and Bola Oboh
Department of Cell Biology and Genetics, University of Lagos, Akoka, Lagos, Nigeria
TETFUND Centre of Excellence in Biodiversity Conservation and Ecosystem Management

Chapter 4. Occupational Exposure and Genome Instability: The Effects on Human Health
Malu Siqueira Borges1, MD, Juliana da Silva1,2, PhD, Rafael Rodrigues Dihl1, PhD, and Ana Letícia Hilário Garcia1,2, PhD
1Laboratory of Genetic Toxicology, PPGBioSaúde Lutheran University of Brazil (ULBRA), Canoas, Rio Grande do Sul, Brazil
2Laboratory of Genetic Toxicology, La Salle University (UniLaSalle), Canoas, Rio Grande do Sul, Brazil

Chapter 5. The Genotoxicity of Cement Dust: Current Screening Advances and Future Prospects
Wasiu M. Owonikoko1 and Chibuisi G. Alimba2,3
Department of Physiology, Igbinedion University, Okada, Nigeria
2Department of Zoology, University of Ibadan, Ibadan, Nigeria
3Department of Toxicology, Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany


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