Forskolin: Sources, Mechanisms of Action and Health Effects


Marty H. Walker (Editor)

Series: Biochemistry Research Trends
BISAC: MED071000

Forskolin is a labdane diterpene, isolated from plant Coleus forskohlii (Lamiaceae), which has been used in traditional Indian medicine, Ayurveda. Forskolin increases the production of cyclic adenosine monophosphatase (cAMP) by activating adenylate cyclase. Forskolin has many pharmacological effects and some of them are independent of cAMP. Coleus forskohlii root, which contains forskolin has been used in Ayurvedic medicine for cardiovascular disorders and gastrointestinal disorders. Recently, forskolin has been used as anti-obesity and anti-glaucoma agents. This book discusses the sources, mechanisms of action and health effects of forskolin. (Imprint: Novinka)


Table of Contents

Table of Contents


Chapter 1 – UV Protection of the Skin by Topically-Applied Forskolin (pp. 1-30)
Alexandra Amaro-Ortiz, Mary Boulanger and John D’Orazio (University of Kentucky College of Medicine, Markey Cancer Center and the Graduate Center for Toxicology, Lexington, KY, USA, and others)

Chapter 2 – Oral Administration of Forskolin Decreases Retinal Damage After Experimental Induction of Ocular Hypertension in the Rat (pp. 31-50)
Nicola Pescosolido, Gianfranco Scarsella and Dario Rusciano (Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Sapienza – Università di Roma, Roma, Italy, and others)

Chapter 3 – Forskolin Embryotoxicity in Initial Stages of the Embryonic Development in Chick (pp. 51-66)
Lucia de Fatima Sobral Sampaio, Renato Correa Nogueira and Maria Auxiliadora Pantoja Ferreira (Laboratory of Biochemistry of the Central Nervous System Development, Biological Sciences Institute. Federal University of Pará, and others)

Chapter 4 – Forskolin and Coleus Forskohlii: Clinical Applications for Overweight and Obesity (pp. 67-82)
Seika Kamohara (Health Science University, DHC Corporation, Tokyo, Japan)


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