Flavonols as Cancer Preventive Agents: Recent Updates
Pushpendra Singh (Author) , Shashank Kumar (Author)
Series: Cancer Etiology, Diagnosis and Treatments
Target Audience: Research laboratories working in the field of Natural Products, Pharmaceutical Sciences and Medicinal Chemistry. Graduate, Post graduate and PhD students in the field of Life sciences, Health Sciences, Natural products, Pharmaceutical Sciences and Medicinal Chemistry. University libraries dealing with the Life sciences, Health Sciences, Natural products, Pharmaceutical Sciences and Medicinal Chemistry
This book describes primary results on the leading edge of in silico and in vitro cancer research and summarizes the anticancer activity of pharmacologically important flavonols such as quercetin, morin, kaempferol, fisetin, galangin, diosmetin, and cianidanol. Natural products are a prime source of lead compounds suitable for further modification during drug development. Cancer drug discovery is a risky, costly, and resource-consuming process. In the modern arena, molecular computer modeling in anticancer drug development is utilized to speed up hit identification and optimization of the pharmacological profile. The first chapter of this book deals with computer-aided drug discovery and anticancer drug design using pharmacological active flavonols. In further chapters, the authors discuss the in vitro and in vivo advancement in anticancer research on important flavonols such as quercetin, morin, kaempferol, fisetin, galangin, diosmetin, and cianidanol. Anticancer advancement research related to various cancers is summarized and discussed, giving special emphasis on the effect on apoptosis, migrations, and growth via various signaling pathways. The book encompasses the literature as well as target identification for the selected flavonols for their in silico anticancer potential. Moreover, it also contains experimentation results and discussion on the pharmacological properties, including ADME/T, of the flavonols. Overall, this book can lay a good basis for the subsequent rise for its application as a therapeutic drug in the near future.
Table of Contents
Chapter 1. Computer-Aided Anticancer Drug Design (CADD) and Natural Compounds
Chapter 2. Roles of Quercetin in Cancer Prevention: In silico and In vitro Advancement
Chapter 4. Kaempferol: Anticancer Activity
Chapter 5. Fisetin Cancer Prevention Activity: In silico and In vitro Advancement
Chapter 6. Galangin Cancer Prevention Activity: In silico and In vitro Advancement
Chapter 7. Diosmetin Cancer Prevention Activity: In silico and In vitro advancement
Chapter 8. Anticancer Activity of Cianidanol: In silico and In vitro Advancement
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