Dietary Flavonoids Interfere with Cancer Radiotherapy


Katrin Sak, PhD
Head of the NGO Praeventio, Tartu, Estonia

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED080000

In parallel with the continuous rise of cancer incidence, efficient treatment becomes an increasingly important public health concern. Radiotherapy has remained one of the most important anticancer approaches for clinical management of a variety of human tumors, as at least half of all oncological patients receive this therapy at some stages of their disease. With the hope to attain greater anticancer response, the interest in using natural plant-derived products as complementary treatments to conventional radiotherapy has substantially increased in the recent years. However, the interactions between phytochemicals and ionizing radiation are not always known and can be often unpredictable.

Therefore, in this book, the current findings about the combined treatments of malignant cells with radiation and flavonoids, the largest group of human dietary plant polyphenols, are described. These data show that under carefully chosen dosage-schedule regimens, certain flavonoids or their natural mixtures can behave as potent radiosensitizers, augmenting radiotherapeutic efficacy in different preclinical cancer models. Such radiosensitizing action of flavonoids can be achieved through modulation of the redox status and suppression of several cellular survival pathways activated by radiotherapy, ultimately leading to the death of malignant cells. As flavonoids can concurrently protect normal healthy cells from irradiation-induced injury and thereby minimize toxic adverse reactions, use of these plant-derived agents as complementary approach to radiotherapy might open new avenues for enhancement of clinical outcome. Therefore, combining conventional anticancer modalities with conscious intake of flavonoid supplements as adjuvant agents might be an important future strategy to boost the therapeutic success in the treatment of various human malignancies.
(Imprint: Nova Medicine and Health)



Table of Contents




Chapter 1. The Role of Radiotherapy in Cancer Treatment: Current Opportunities and Challenges

Chapter 2. Radiotherapy-Induced Cellular Responses: Major Mechanisms Behind Radioresistance

Chapter 3. Plant Flavonoids as Potential Dietary Radiosensitizers

Chapter 4. Modulation of Radiotherapeutic Efficacy by Dietary Flavonoids

Chapter 5. Conclusions and Further Challenges


About the Author



* Academic staff of universities and medical schools who teach courses on oncology and oncotherapy, including complementary approaches to traditional anticancer modalities. This book can be a valuable educational material also for medical students.
* Cancer patients undergoing radiotherapy. The knowledge presented in this book could be a supportive material for cancer patients to: 1) appreciate and understand the potential role of dietary supplements on therapeutic efficacy, and 2) interfere with radiotherapy in a conscious way to achieve the best clinical outcome.
* Clinical doctors, nurses and nutritional advisors, i.e., all the clinical staff who is everyday faced with numerous questions of oncological patients concerning nutrition and intake of dietary supplements.
* Scientific community. This book is a valuable basic material for scientists who work on the development of novel radiosensitizers using different malignant models.

Keywords: Dietary flavonoids, Food and cancer, Phytochemicals, Radiotherapy, Cancer treatment

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