Current Therapeutic Strategies for the Management of Cancer

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Priyanka Kriplani, PhD – Associate Professor, Guru Gobind Singh College of Pharmacy, Haryana, India
Ashwani Kumar Dhingra, PhD – Professor, Guru Gobind Singh College of Pharmacy, Haryana, India
Ajmer Singh Grewal, PhD – Associate Professor, Guru Gobind Singh College of Pharmacy, Haryana, India
Geeta Deswal, PhD – Guru Gobind Singh College of Pharmacy, Haryana, India
Bhawna Chopra, PhD – Associate Professor, Guru Gobind Singh College of Pharmacy, Haryana, India
Peeyush Kaushik – Assistant Professor, Guru Gobind Singh College of Pharmacy, Haryana, India

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: HEA039030; MED072000; MED071000
DOI: https://doi.org/10.52305/EQTP8014

Cancer is a leading cause of death worldwide, and the efficacy of cancer drugs is often limited due to poor bioavailability and drug resistance. Traditional treatment strategies, such as surgery, chemotherapy, radiotherapy, immunotherapy, and combinational regimens, are associated with side effects and fail to deliver an adequate amount of the drug to the target site. Chemotherapy has paved the way for novel drug delivery systems in cancer treatment, enhancing efficacy, patient compliance and reducing side effects by specifically targeting the site of action. These novel drug delivery systems employ various drug delivery systems such as nanoparticles, liposomes, niosomes, transferosomes, transdermal drug delivery systems, intranasal drug delivery systems, and others to improve drug solubility, stability, and controlled release patterns. The application of novel drug delivery systems in chemoimmunotherapy has become a hotspot in cancer treatment, and this book explores the potential of gene therapy alongside recent patents on anticancer formulations. The discussion also extends to clinical trials, which are crucial for validating these novel approaches and ensuring that effective treatments reach patients. The initial chapters provide an overview of current therapeutic approaches, while subsequent chapters focus on the role of nanotechnology in cancer treatment, emphasizing various nanoparticle-based formulations. Liposomes, transdermal drug delivery systems, microsomes, phytosomes, niosomes, intranasal drug delivery systems, and gene-drug delivery systems for cancer therapy are also discussed. Furthermore, the book addresses novel drug delivery systems, patents, and ongoing clinical trials, offering valuable insights for researchers, academicians, and scientists working towards advancements in the therapeutic management of cancer.

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Table of Contents

Preface

Chapter 1. An Introduction to Novel Drug Delivery Systems for Cancer Therapy
Priyanka Kriplani, Bhawna Chopra, Peeyush Kaushik, Geeta Deswal, Ajmer Singh Grewal and Ashwani K. Dhingra
Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India

Chapter 2. The Current Therapeutic Management of Cancer
Sonam Grewal1, Sanchit Dhankhar2, Madhukar Garg3, Prateek Sharma4, Ajmer Singh Grewal5 and Geeta Deswal5
1
M.M. College of Pharmacy, M.M. (Deemed to be University), Mullana, Ambala, Haryana, India
2Swami Vivekanand Institute of Engineering and Technology, Ramnagar, Rajpura, Punjab, India
3Chitkara College of Pharmacy, Chitkara University, Punjab, India
4Government Pharmacy College, Nagrota Bagwan, Kangra, Himachal Pradesh, India
5Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India

Chapter 3. Nanoparticles for the Treatment of Cancer
Sanchit Dhankhar1 , Samrat Chauhan1 , Monika Saini2, Nitika1,3 , Sonam Grewal2 , Geeta Deswal4 , Thakur Gurjeet Singh1 and Sumit Sharma5
1
Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India
2M. M. College of Pharmacy, M. M. (Deemed to be University), Mullana, Ambala, Haryana, India
3Ganpati Institute of Pharmacy, Bilaspur, Yamuna Nagar, Haryana, India
4Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India
5University Institute of Pharma Sciences, Chandigarh University, Gharuan, Punjab, India

Chapter 4. The Role of Nanotechnology in the Management of Cancer
Srashti Maheshwari, Tarun Shishodia, Kandasamy Nagarajan and Parul Grover
KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad, Uttar Pradesh, India

Chapter 5. Liposomes for the Treatment of Cancer
Jyoti Malik, Nisham Rani, Meena Devi and Ritu Kataria
G. V. M. College of Pharmacy, Sonipat, Haryana, India

Chapter 6. A Transdermal Drug Delivery System for the Treatment of Cancer
Ashna, Rohit Kamboj, Sweta Kamboj, Shikha Kamboj, Prerna Sharma and Kumar Guarve
Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India

Chapter 7. Microspheres for the Treatment of Cancer
Shikha Baghel Chauhan and Banaja Swain
Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India

Chapter 8. Phytosomes for the Treatment of Cancer
Smita Narwal1, Gurvirender Singh2 and Neha Yadav1
1
Global Research Institute of Pharmacy, Radaur, Yamunanagar, Haryana, India
2Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, India

Chapter 9. Niosomes for the Treatment of Cancer
Neelam Singh1,2, Chaitanya Vinayak Narayan1, Puneet Gupta3, Radha Goel4 and Neha SL5
1
I. T. S. College of Pharmacy, Delhi-Meerut Road, Ghaziabad, Uttar Pradesh, India
2Adjunct faculty at Management and Science University, Shah Alam, Selangor, Malaysia
3Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India
4Lloyd Institute of Management and Technology (Pharm.), Greater Noida, Uttar Pradesh, India
5Harlal Institute of Management and Technology, College of Pharmacy, Greater Noida, Uttar Pradesh, India

Chapter 10. An Intranasal Drug Delivery System for the Treatment of Cancer
Radha Goel1, Rosaline Mishra2, Niharika Lal2, Neelam Singh3 and Chaitanya Vinayak Narayan3
1
Lloyd Institute of Management and Technology, Knowledge Park-II, Greater Noida, Uttar Pradesh, India
2Metro College of Health Sciences and Research, Greater Noida, Uttar Pradesh, India
3I. T. S. College of Pharmacy, Muradnagar, Ghaziabad, Uttar Pradesh, India

Chapter 11. An Intranasal Delivery of Nanoparticulate Systems via BBB for the Management of Cancer
Deepshi Arora1, Yugam Taneja2, Anjali Sharma1 and Ashwani K. Dhingra1
1
Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India
2Zeon Lifesciences Ltd, Paonta Sahib, Himachal Pradesh, India

Chapter 12. Gene Drug Delivery for the Treatment of Cancer
Gaurav Chaudhary1, Janhavi Singh1, Chaitanya Vinayak Narayan1, Neelam Singh1 and Puneet Gupta2
1
I.T.S. College of Pharmacy, Delhi-Meerut Road, Ghaziabad, Uttar Pradesh, India
2Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India

Chapter 13. Gene Therapy for the Management of Cancer
Sarika Devi1, Vaibhav Rathi1,2, Poonam Joshi3 and Purabi Saha3
1
Quantum School of Health Sciences, Quantum University, Roorkee, Uttrakhand, India
2College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India
3Uttaranchal Institute of Pharmaceutical Sciences Uttaranchal University, Dehradun, Uttrakhand, India

Chapter 14. Clinical Studies for the Treatment of Cancer
Rishabh Chalotra1, Meenakshi Dhanawat2, Garima3, Kashish Wilson3 and Prerna Sharma4
1
Department of Pharmacology, Central University of Punjab, Bathinda, India
2Amity Institute of Pharmacy, Amity University Haryana, Manesar, Gurugram, Haryana, India
3M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, India
4Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India

Chapter 15. Recent Patents for the Treatment of Cancer
Anjali Sharma1, Shefali Mehla2, Girish Chandra Arya2, Devkant Sharma3 and Prabhjot Singh Bajwa3
1
Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India
2University Institute of Pharma Sciences, Chandigarh University, Gharuan, Mohali, Punjab, India
3Ch. Devi Lal College of Pharmacy, Jagadhari, Yamunanagar, Haryana, India

Index

About the Editors

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