Current Immunosuppressive Therapy in Organ Transplantation

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Huifang Chen, MD, PhD (Editor)
Department of Surgery, Faculty of Medicine, Research Center, CHUM, Notre-Dame Hospital, CHUM, University of Montreal, Montreal, Canada

Shiguang Qian, MD, MSc (Editor)
Associate Professor of Immunology Surgery, Department of Immunology, Lerner Research Institute, Department of General Surgery, Transplant Centre, Digestive Disease Institute, Cleveland. OH, USA

Series: Organ Transplantation Research Horizons
BISAC: MED085070

Organ transplantation has revolutionized the treatment for end-stage organ failure. Immunosuppression is still a major approach currently used in the prevention and treatment of allograft rejection. Both editors Dr. Chen and Dr. Qian have been contributing to preclinical evaluation of immunosuppressants for more than 25 years in North America. Experts from the United States, Canada, the United Kingdom, China, Japan, Germany, Sweden, Hungary and Brazil contributed 23 chapters to this book, providing details of immunological basis in transplantation.

They also describe six classes of immunosuppressive agents (calcineurin inhibitors, mTOR inhibitors, JAK-STAT inhibitors, antiproliferative agents, costimulation blockers and corticosteroids), as well as ischemia/reperfusion injury treated agents. Additionally, the new development of cell therapy in the induction of transplant tolerance is introduced. This book provides many important references for the research direction of novel immunosuppressants. Readers that will find this book useful include transplant physicians, surgeons, nurses, immunologists, pharmacologists, pharmacists, medical students, residents and trainees in transplantation.
(Imprint: Nova Biomedical)

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Table of Contents

Foreword
(Pierre Daloze, University of Montreal, Canada)

Preface
(Huifang Chen and Shiguang Qian, University of Montreal, Canada, and Cleveland Clinic, USA)

Part I: Immunologic Basis

Chapter 1
Immunology Principles in Organ Transplantation
(Daniel Joyce, Cleveland Clinic, USA)

Chapter 2
Cellular and Humoral Responses in Organ Transplantation
(Wenhao Chen, Cornell University, USA)

Chapter 3
Historical Remarks of Immunosuppressive Therapy in Organ Transplantation
(Huifang Chen, Anlun Ma, and Pierre Daloze, University of Montreal, Canada)

Chapter 4
Animal Models in Immunosuppression
(James McDaid, Dept of Transplant Surgery, City Hospital, Belfast, UK)

Chapter 5
Ethical Issues of Immunosuppressive Drugs Use in Organ Transplantation
(Kupa Bilolo and Edna Montero, University of Montreal, Canada, and University of Sao Paulo Medical School, Brazil)

Part II: Therapeutic Agents

Chapter 6
Glucocorticoids
(Yanxin Hu, University of Montreal, Canada)

Chapter 7
Small Molecules in Solid Organ Transplantation with Cytostatic Antiproliferative Effects
(René H. Tolba, Institute Fur Versuchstierkunde, Universitsklinikum Aachen, Germany)

Chapter 8
Calcineurin Inhibitors
(Junzheng Peng and Edna Montero, CRCHUM, University of Montreal, Canada, and University of Sao Paulo Medical School, Brazil)

Chapter 9
Inhibitors of Mammalian Target of Rapamycin
(Kupa Bilolo and Huifang Chen, University of Montreal, Canada)

Chapter 10
Immunomodulation Therapy by the Control of Immune Cell Trafficking
(Takashi Murakami and Eiji Kobayashi, Laboratory of Tumor Biology, Takasaki University of Health and Welfare, Japan, and Department of Organ Fabrication, Keio University, Japan)

Chapter 11
Protein Kinase C Inhibitors
(Guang Yu, Liaoning Medical University, China)

Chapter 12
Agents Targeting JAK3 in Organ Transplantation
(Hao Dun, University of Montreal, Canada)

Chapter 13
Costimulation Blockers
(Lijun Song, University of Montreal, Canada)

Chapter 14
Adhesion Molecules: Therapeutic Targets for Allograft Rejection and Ischemia-Reperfusion Injury
(René H. Tolba, Institute Fur Versuchstierkunde, Universitsklinikum Aachen, Germany)

Chapter 15
Agents Targeting B-cells and the Humoral Responses
(Mihai Oltean, the Transplantation Institute, Sahlgrenska University Hospital, Sweden)

Chapter 16
Agents Targeting Plasma Cells
(Paulo N. Martins, University of Massachusetts, USA)

Chapter 17
Immunosuppressive Antibodies
(Guang Yu, and Xuemin Xu, Liaoning University, China)

Chapter 18
Complement Inhibitors
(Paulo N. Martins, University of Massachusetts, USA)

Chapter 19
Agents Targeting Ischemia-Reperfusion Injury
(Norbert Nemeth, Balazs Nemes, University of Debrecen, Hungary)

Part III: Cell Therapy in Induction of Transplant Tolerance

Chapter 20
Cellular Therapies in Induction of Transplantation Tolerance
(Sumantha Bhatt and Shiguang Qian, Cleveland Clinic, USA)

Chapter 21
Stem Cell-Derived Immunosuppressive Cells Therapy in Organ Transplantation
(Xiaokang Li, Chief, Division of Transplantation Immunology, National Research Institute for Child Health and Development, Okura, Setagaya-Ku, Tokyo, Japan)

Chapter 22
Does MSCs have a place in Transplantation?
(Feng Lin, Department of Immunology, Lerner Research Institute, Cleveland Clinic, USA)

Chapter 23
Donor Hematopoietic Stem Cells
(Joel T. Adler, Beth Amundsen, Tatsuo Kawai, Massachusetts General Hospital, USA)

Index

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