Chronic Disorders of Consciousness: From Research to Clinical Practice

Rocco Salvatore (Editor)
Neurologist and Sexologist, Psychiatry, IRCCS Centro Neurolesi Bonino-Pulejo, Cda Casazza, Messina, Italy

Calabrò Placido Bramanti (Editor)
Neurologist, Scientific Director of IRCCS, Centro Neurolesi Bonino-Pulejo, Messina, Italy

Series: Neuroscience Research Progress
BISAC: SCI089000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Chronic disorders of consciousness comprise a tragic group of conditions for which determining prognosis is a prerequisite for clinical decision-making. The Vegetative State (VS) and the Minimally Conscious State (MCS) are syndromes, encompassing a spectrum of severity with various etiologies, most commonly traumatic brain injury or hypoxic-ischemic or hemorrhagic neuronal injury. They can be a transient stage during recovery from an acute brain insult or can be chronic and stable, usually after a variable period of coma.

Recent advances in neuroimaging are providing new insights into cerebral activity in patients with severe brain damage. The mapping of cognitive processes (mostly by measuring regional changes in blood flow, initially by PET and currently by fMRI, and by measuring regional metabolic changes by MRSI) is providing insight into the functional neuroanatomy and metabolic assessment of consciousness. However, differential diagnosis of SV and MCS is still difficult and their complex management involves many different and skilled healthcare professionals.

This book is aimed at examining the pathophysiology of consciousness disorders with their multifaceted assessment and treatment, including new diagnostic tools and novel prognostic markers, and the important bioethical issues concerning “the end of life” and the “dignity of the person”. (Imprint: Nova Biomedical )

Preface

Chapter 1. Anatomo-Physiology of Consciousness
(Rocco Salvatore Calabrò and Placido Bramanti, IRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, Italy)

Chapter 2. The Wide Spectrum of Consciousness Disorders
(Rocco Salvatore Calabrò, Angela Marra, Giuseppina Digangi, Carmela Casella, Placido Bramanti and Rosalia Silvestri, IRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, Italy, and others)

Chapter 3. Clinical and Instrumental Evaluation of Chronic Disorders of Consciousness
(Serena Gennaro, Nunzio Muscarà, Antonio Leo, Simone Reitano, David Militi, Placido Bramanti and Rocco Salvatore Calabrò, Centro Cardinal Ferrari, Fontanellato, Italy, and others)

Chapter 4. Neuroimaging Assessment in Low Level Consciousness Patients
(Silvia Marino and Nicola De Stefano, IRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, Italy, and others)

Chapter 5. New Diagnostic Tools and Markers of Recovery in Consciousness Disorders
(Silvia Marino, Placido Bramanti, Marina Barresi, Debora Celi, Rosella Ciurleo, Simona De Salvo, Valeria Foti, Sabrina Giacoppo and Rocco Salvatore Calabrò, IRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, Italy)

Chapter 6. The Pharmacotherapy of “Awakening”
(Rocco Salvatore Calabrò, Patrizia Pollicino and Placido Bramanti, IRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, Italy)

Chapter 7. Rehabilitation and Nursing, Caregivers and Psychological Support in Chronic Disorders of Consciousness
(Silvia Marino, Annalisa Baglieri, Francesco Corallo, Rosaria De Luca, Letteria Spadaro, Rocco Salvatore Calabrò and Placido Bramanti, IRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, Italy)

Chapter 8. Nutrition and Other Medical Problems in VS and MCS
(Daniela Floridia, Valeria Conti Nibali, Rocco Salvatore Calabrò, Placido Bramanti and Carlo Salviera, IRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, Italy)

Chapter 9. Rehabilitation Paths in Severe Brain Injury
(Fabrizio Denaro, Maria Zanghì, Graziano Giuffrida and Placido Bramanti, IRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, Italy)

Chapter 10. Legal and Bioethical Issues in Chronic Consciousness Disorders
(Rocco Salvatore Calabrò and Vincenzo Barone, IRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, Italy)

Index

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