David Aebisher, PhD, DSc

Dr. David Aebisher graduated from the University of Wyoming USA where he then obtained his PhD in physical-organic chemistry for the defense of his doctoral thesis entitled Mechanistic Studies on the Sulfide-Singlet Oxygen Reaction Surface. He obtained his habilitation in medical sciences at the Medical University of Silesia in Poland for the scientific achievement entitled Localized Delivery, Release and Tracking of Highly Reactive Anticancer and Antimicrobial Agents. Dr Aebisher has worked at the University of Wyoming, University of Illinois at Chicago, Shorter University and the City University of New York, USA . For five years at the Medical College of The University of Rzeszów, he has been conducting research on the use of photodynamic therapy and singlet oxygen dosimetry.

Dr David Aebisher’s research has involved the localised release, delivery and tracking of highly reactive anticancer and antimicrobial agents in biological media including bacteria, fungi, and cancer cell cultures. The highly reactive anticancer and antimicrobial agents he has investigated for release include sulfur species from polysulfane decomposition such as triatomic sulfur, reactive oxygen species and photosensitizing dyes that can generate ROS at a distance from the site of release. These mechanisms are complex and generally not fully understood. His current research is on the development of devices for the localized delivery of singlet oxygen for PDT. PDT is a treatment that uses a combination of light-absorbing photosensitizers (PS) and dissolved oxygen to kill cancer. PDT is a method that can be controlled with regards to the location of the treatment as it requires selective illumination of the treatment area with light. Selective illumination and light activation then enables selective damage of diseased tissue without damaging the surrounding healthy tissue. Analysis of PDT treatment depth by flow cytometry will complement MRI. The treatment of cancer continues to be a challenging task for Dr Aebisher’s research. He has published more than 300 scientific papers and book chapters in the PDT field.

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