Zika Virus Disease: Prevention and Cure

Sushil K. Sharma, Ph.D.
Academic Dean, American International School of Medicine (AISM), Georgetown, Guyana, South America, US Corporate Headquarters, Stone Mountain, Georgia, USA

Series: Virology Research Progress
BISAC: MED022090

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The author was motivated to write this important book because currently there is no systematically-written document on the ZIKV disease, which could serve at this crucial moment as a textbook for medical students, physicians, nurses, and other healthcare providers as well as a reference book for basic researchers, professors, and the general public.

The original concept of ZIKV-Charnolopathy due to compromised mitochondrial bioenergetics in highly vulnerable (neural progenitor cells, spermatocytes, oocytes etc.) cells and its amelioration by physiological and/or pharmacological interventions is based on years of research experience. This book describes unique organ and disease-specific Charnoly body (CB) inhibitors, charnolophagy inducers, CB sequestration inhibitors, and chanolophagosome stabilizers as promising charnolopharmacotherapeutics. They are meant to aid in the prevention and treatment of the ZIKV-linked diversified spectrum of neurodevelopmental anomalies (embryopathies) in newborn infants and Guillain Barre’ Syndrome (GBS) in adults. Clinical management of ZIKV-induced GBS employing IV immunoglobulin and plasmapheresis (plasma exchange) is also described.
(Imprint: Nova Biomedical)

Preface

Acknowledgement

Main Message

Words of Wisdom

ZIKV Highlight

Abbreviations

Definitions

About this Book

About the Author

Part 1 - ZIKA Disease (Epidemiology)

Chapter 1. Global Spread of ZIKV Disease

Chapter 2. Clinical Epidemiology of ZIKV Disease

Chapter 3. ZIKV Linked Microcephaly and Other Spectrum of Neurodevelopmental Anomalies

Part 2 - ZIKV Molecular Biology (Concepts and Mechanisms)

Chapter 4. Compromised Charnolophagy (CB Autophagy) as a Cause of Microcephaly in ZIKV Disease (Basic Molecular Biology of ZIKV Disease)

Part 3 - Clinical Symptoms and Diagnosis of ZIKV Disease

Chapter 5. Clinical Symptoms and ZIKV Spectrum of Neurodegeneration

Chapter 6. Clinical and Laboratory Diagnosis of ZIKV Disease

Chapter 7. Clinically Interesting Case Reports of ZIKV Disease

Part 4 - Management of ZIKV Disease

Chapter 8. Prevention of ZIKV Disease

Chapter 9. Treatment of ZIKV Disease

Chapter 10. Personalized Theranostics of ZIKV Disease

Part 5 - Recent Trends and Drug Discovery for ZIKV Disease

Chapter 11. Recent Update of ZIKV Disease (Part-I)

Chapter 12. Recent Update of ZIKV Disease (Part-II)

Chapter 13. Recent Update of ZIKV Disease (Part-III)

Part 6 - Experimental Models of ZIKV Disease

Chapter 14. In-Vitro and In-Vivo Experimental Models of ZIKV Disease

Part 7 - Novel Drug Discovery for ZIKV Disease

Chapter 15. Computer-Based Omics (Vaccinomics) for Novel Drug Discovery of ZIKV Disease

Chapter 16. Charnolopharmacotherapeutics of ZIKV Disease

Conclusion

Index

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