Wnt Signaling in Colon Cancer Stem Cells

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Tianxin Yu (Editor)
Xi Chen (Editor)
Chunming Liu (Editor)
University of Texas Medical Branch, Galveston, TX, and others

Series: Cancer Etiology, Diagnosis and Treatments, Stem Cells and Regenerative Medicine
BISAC: MED062000

Colorectal cancer is the second leading cause of cancer-related death in the United States. Among many gene mutations associated with colorectal cancer, mutation of APC (adenomatous polyposis coli) or ß-catenin, which activates Wnt signaling, represents the initiation step of colon tumorigenesis. Wnt signaling is known to play multiple roles in early development and formation of human cancers. In addition, Wnt signaling also regulates the self-renewal and differentiation of adult stem cells. Recently, cancer stem cells have emerged as an exciting new concept in cancer research. This book discusses the development and trends in the field of cancer stem cell research, with emphasis on colon cancer stem cells. (Imprint: Nova Biomedical)

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Table of Contents

Abstract

Wnt signaling pathway

Wnt signaling in the intestine

Wnt signaling in colon cancer

Intestinal stem cells

Colon cancer stem cells

Summary

Acknowledgments

References

Index

Additional information

Binding