Table of Contents
Table of Contents
Abstract
Wnt signaling pathway
Wnt signaling in the intestine
Wnt signaling in colon cancer
Intestinal stem cells
Colon cancer stem cells
Summary
Acknowledgments
References
Index
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Tianxin Yu (Editor)
Xi Chen (Editor)
Chunming Liu (Editor)
University of Texas Medical Branch, Galveston, TX, and others
Series: Cancer Etiology, Diagnosis and Treatments, Stem Cells and Regenerative Medicine
BISAC: MED062000
Colorectal cancer is the second leading cause of cancer-related death in the United States. Among many gene mutations associated with colorectal cancer, mutation of APC (adenomatous polyposis coli) or ß-catenin, which activates Wnt signaling, represents the initiation step of colon tumorigenesis. Wnt signaling is known to play multiple roles in early development and formation of human cancers. In addition, Wnt signaling also regulates the self-renewal and differentiation of adult stem cells. Recently, cancer stem cells have emerged as an exciting new concept in cancer research. This book discusses the development and trends in the field of cancer stem cell research, with emphasis on colon cancer stem cells. (Imprint: Nova Biomedical)
Table of Contents
Abstract
Wnt signaling pathway
Wnt signaling in the intestine
Wnt signaling in colon cancer
Intestinal stem cells
Colon cancer stem cells
Summary
Acknowledgments
References
Index
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