What Doesn’t Kill Us, Makes Us Stronger: Reducing Oxidative Stress and Damage through Adaptive Stress Responses


Borut Poljsak
University of Ljubljana, Faculty of Health Sciences, Ljubljana, Slovenia

Irina Milisav
University of Ljubljana, Slovenia

Series: Human Anatomy and Physiology
BISAC: SCI036000

Oxidative stress, which is caused by endogenous and exogenous reactive-oxygen-species (ROS) formation, may significantly affect health-span and longevity. Endogenous oxidative stress could be attenuated in two ways: by the reduction of ROS formation and by quenching ROS with antioxidants. Numerous results of clinical trials in which individuals received one or more synthetic antioxidants failed to demonstrate conclusive benefits of antioxidant supplementation. Even oral supplementation with endogenous antioxidant enzymes cannot alter the antioxidant balance due to their degradation in the digestive system.

Likewise, life-span or health-span is not increased significantly in genetically modified models overexpressing antioxidant enzymes. An alternative approach to attenuate the ROS-induced stress/damage may be through triggering an adaptive stress response in order to increase the endogenous antioxidant and damage repair processes. Moderate stress induced by CR, physical activity or mimetic compounds may induce such activation of endogenous antioxidative defense and cellular repair processes. These processes may increase cellular resistance to subsequent more severe stress and do not seem to interfere with ROS-dependent cellular signaling.
(Imprint: Nova Biomedical)



Table of Contents


Chapter 1 – Introduction (pp. 1-2)

Chapter 2 – Defence Mechanisms against Free Radical-Induced Oxidative Stress and Damage (pp. 3-12)

Chapter 3 – Potential, Alternative Approaches for Modulating Life-Span and Health-Span (pp. 13-26)

Chapter 4 – Signaling Pathways Important for Cellular Damage Repair and Mimetics (pp. 27-30)

Chapter 5 – Modulators of Signaling Pathways and Mimetics (pp. 31-36)

Chapter 6 – Dietary Supplements That Enhance DNA Repair (pp. 37-48)






This book will be of interest for everybody who is concerned about health and aging process. The book can be recommended to medical doctors and health professionals of different specialties (geriatrics, neurologists, pathologists, nutritionists and others). The book will also be helpful to students from various health/nutrition/medicine programs.
On an Academic level, For health professionals and students, graduate and undergraduate, and layman with background/strong interest in oxidative and preventive medicine.

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