Vitamin B12: Chemical Aspects, Transport, Cause and Symptoms of Deficiency, Dietary Sources, and Health Benefits 

Elena Mutti (Editor)
Department of Biomedical Sciences for Health, University of Milan, Milan, Italy

Series: Biochemistry Research Trends
BISAC: SCI007000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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In mammals, vitamin B12 (also called cobalamin (Cbl)) is involved in several metabolic pathways and necessary for the proliferation and survival of different cell types. Due to an impaired vitamin uptake, a mild, chronic deficiency of Cbl is quite common in the elderly population as well as vegetarians and vegans. A status of Cbl-deficiency induces several disorders including severe anaemia and a neuropathy, and has horrible consequences in fetal development. Based on the information above, it is very important to analyse all the aspects of Cbl in both chemical and clinical trials.

With this book, researchers as well as medical doctors and nutritionists can learn of recent advances and answers to basic questions on chemical structures, delivery systems, and clinical aspects of Cbl function. In the first half, we will learn the importance and new applications of Cbl analogues, as well as the complicate arranging of Cbl transporters and finally the recent frontiers on Cbl epigenetic role. The latter part includes the issues linked to the Cbl-deficient diagnostic examinations, Cbl pharmacological uses and recent advances in foods containing Cbl (concentration, bio-availability and enriched food). Finally, ample space will be left to discuss the effect of Cbl-deficiency, from the early cases to the latest study on Cbl involvement in the immune system and its role in carcinogenesis.
(Imprint: Nova)

Preface

Chapter One
Natural Cobalamins – Their Structure, Chemical Reactivity and Co-Enzymatic Role
(Miriam Hunger and Bernhard Kräutler, Institute of Organic Chemistry and Center of Molecular Biosciences, University of Innsbruck, Innsbruck, Austria)

Chapter Two
Vitamin B12 Absorption and Transport in Mammals
(Omar Abuyaman, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark)

Chapter Three
B12-Biosynthesis, Natural Cobalamin Analogues, Synthetic Cobalamins and Nomenclature
(Markus Ruetz, Department of Biological Chemistry, University of Michigan, Ann Arbor, USA and Florian J. Widner, Department of Plant and Microbial Biology Department, University of California, Berkeley)

Chapter Four
Non Co-Enzymatic Role of Vitamin B12
(Elena Mutti, Department of Biomedical Sciences for Health, University of Milan, Milan, Italy)

Chapter Five
Causes of Vitamin B12 Deficiency
(Elena Mutti, Department of Biomedical Sciences for Health, University of Milan, Milan, Italy)

Chapter Six
Laboratory Testing for Vitamin B12 Deficiency
(Elena Mutti, Department of Biomedical Sciences for Health, University of Milan, Milan, Italy)

Chapter Seven
Pathological Effects of Vitamin B12 Deficiency
(Elena Mutti and Alessandra Colciago, Department of Biomedical Sciences for Health, and Department of Pharmacological and Biomolecular Sciences, University of Milan, Milano, Italy)

Chapter Eight
Pharmacological use of Vitamin B12: Vitamin B12 in Therapy
(Alessandra Colciago, Department of Pharmacological and Biomolecular Sciences, University of Milan, Milano, Italy)

Chapter Nine
Food Source of Vitamin B12
(Elena Mutti, Department of Biomedical Sciences for Health, University of Milan, Milan, Italy)

Index

This book would be intended for biomedical and chemist researchers, as well as, medical doctors and nutritionists. Vitamin B12 exerts its effect on many cells of the body and therefore its interest covers various areas (neurology, hematology, obstetrics, pediatrics, gastroenterology, dentistry and recently oncology). It is a support for both graduate course than for continuing medical/biological training. Pharmaceutical companies working on vitamin B12, vitamin supplements or drug for nervous system could be also interested.

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