Visualization of Archaic Cancer Attractors and Chromatin Regulators Connecting to Ageing, Robustness and Cellular Reprogramming

Yue Zhang
Harvard Medical School, Boston, MA, USA

Stuart K Calderwood
Harvard Medical School, Boston, MA, USA

Hisashi Moriguchi
The University of Tokyo, Tokyo, Japan

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

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Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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In this book, the authors start from evolutionary biology and developmental biology to make an explanatory review by using a formal argumentstructure along with our previous visual computation analysis of experimental data from the model organisms Caenorhabbditis elegans, Drosophila melanogaster, Volvox carteri and mammalian systems to answer the questions how and to what extent the chromatin regulators connect to robustness, “archaic” cancer attractors and cellular reprogramming. Finally, they address why cancer is inevitable but reversible. (Imprint: Nova Biomedical)

Preface

Abstract

Introduction

Why Cancer?

New Theories of Carcinogenesis

The Cell Attractors Theory

The Link Between Ageing and CRCs

The Robustness that DAF-21/HSP90 Chaperone Mediates Genome Evolution

The Development Robustness that Daf-12 Hormonal Signaling Buffers of Dauer <-> Adult Switch

The Robustness that the Synmuvb Pathway Buffers Temperature Stress

The Robustness that Pcg Complex Supports Developmental Plasticity <-> Differentiation Onset Decision

The Robustness that Hpl-2/Myb-Muvb Complex Determines Sex Decision

The Robustness Inherent Within Crc-Linked Stemness/Pluripotency

CRCs and Carcinogenesis

CRC Reprogramming and the Matter of Reversibility

Conclusion

References

Index

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