Vincristine: Clinical Uses, Pharmacokinetics and Impacts on Health

Juan M. Coello (Editor)
Yolanda D. Sabres (Editor)

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED000000

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$82.00

Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Vincristine is a naturally occurring alkaloid isolated from the leaves of the plant Catharanthus roseus. It has a wide range of clinical applications. Extracts of the plant have found application in wound healing, in the treatment of diabetic ulcers and diabetes mellitus, and in cancer chemotherapy. In this book, the authors discuss the clinical uses, pharmacokinetics and impacts on health of Vincristine. Topics discussed include Vincristine as an inductor of drug resistance marker expression in neoplastic cells; clinical utility of Vincristine in the treatment of human carcinomas; inadvertent intrathecal administration of Vincristine; and Vincristine’s mechanism of antitumor activity. (Imprint: Nova Biomedical )

Preface pp.vii-xi

Vincristine as an Inductor of Drug Resistance Marker Expression in Neoplastic Cells
(Albert Breier, Denisa Imrichova, Helena Paulikova, Miroslav Barancik, Zdena Sulova, Institute of Biochemistry, Nutrition and Health Protection, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinskeho, Bratislava, Slovak Republic, and others)pp.1-32
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Clinical Utility of Vincristine in the Treatment of Human Carcinomas
(G. Kesava Reddy, Mark A. D’Andrea, University Cancer and Diagnostic Centers, Houston, TX, USA)pp.33-54

Inadvertent Intrathecal Administration of Vincristine
(Peter Gilbar, Cancer and Palliative Care Services, Darling Downs Hospital and Health Service, Australia)pp.55-74

Vincristine: A Review of its Mechanism of Antitumor Activity
(P. Mabeta, Department of Anatomy and Physiology University of Pretoria, Tshwane, South Africa)pp.75-86

Index pp.87-95

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