Vestibular Schwannoma: Pathophysiology, Diagnosis and Treatment

Francesco Dispenza, MD, PhD (Editor)
Otorhinolaryngology Department, Policlinico University Hospital Palermo, Italy

Francesco Martines, MD, PhD (Editor)
Bio.Ne.C. Department, University of Palermo, Palermo, Italy. Istituto Euro-Mediterraneo della Scienza e Tecnologia (I.E.ME.S.T.), Palermo, Italy

Series: Rare Disorders Research Progress
BISAC: MED057000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Vestibular schwannoma is a rare benign tumor arising from VIII cranial nerve. Its localisation into internal auditory canal and cerebello-pontine angle is the main reason for the relevant clinical implication of such disease.

This book develops all the features regarding the vestibular schwannoma, starting from the biology of the tumor, passing to the clinical presentation and instrumental diagnostic pathway to make diagnosis and concluding with therapeutic options linked to several factors regarding tumor size, localisation, symptoms, patient characteristics and outcome.

The chapters are divided into 3 sections: pathophysiology, clinical features and treatment.

Advancements in microsurgical technique and radiosurgery, coupled with an increased understanding of the natural history of the disease, have made modern management of this tumor considerably more complex and the opinions are still divided between conservatism and definitive cure.

The last section includes the rehabilitation after treatment of patients affected by vestibular schwannoma.

The contributions to this book were done by several eminent expert authors in their field, and all references are up to date. This is a robust resource for residents, fellows, and early attending physicians, as well as mid- to later-career physicians who care for patients with vestibular schwannoma.
(Imprint: Nova Medicine and Health)

Preface

Chapter 1. Biology of Vestibular Schwannoma: The Role of PTEN and microRNA-21
(Francesco Dispenza, MD, PhD, Sebastiano Puglisi, MD, and Angelo Immordino, MD, Istituto Euromediterraneo di Scienza e Tecnologia, Palermo, Italy, and others)

Chapter 2. Clinical Features, Instrumental and Imaging for Diagnosis of Vestibular Schwannoma
(Ignazio La Mantia, MD, PhD, Claudio Andaloro, MD, Veronica Castro, MD, Otolayngology Unit, Department of Medical Sciences, Surgical and Advanced Technologies, University of Catania, Catania, Italy)

Chapter 3. Neurofibromatosis Type 2
(Tiziana Fragapane, MD, Emanuela Salzano, MD, Davide Vecchio, MD, PhD, and Maria Piccione, MD, PhD, Associate Professor, Centro di Riferimento Regionale per le Malattie Genetiche e Cromosomiche Rare, A.O. Ospedali Riuniti "Villa Sofia-Cervello", Palermo, Italy, and others)

Chapter 4. Imaging of Vestibular Schwannoma
(Paola Feraco,MD, Silvia Piccinini, MD, Giuseppe Salvaggio, MD, and Cesare Gagliardo, MD, PhD, Department of Radiology, Ospedale S. Chiara, Azienda Provinciale per i Servizi Sanitari, Trento, Italy, and others)

Chapter 5. Solitary Vestibular Schwannoma: Decision Making of Treatments
(Francesco Dispenza, MD, PhD, Istituto Euromediterraneo di Scienza e Tecnologia, Palermo, Italy, and others)

Chapter 6. Conservative Management of Vestibular Schwannoma
(Elisabetta Zanoletti and Diego Cazzador, Unit of Otolaryngology, Department of Neurosciences, University of Padova, Padova, Italy, and others)

Chapter 7. The Enlarged Translabyrinthine Approach
(Falcioni Maurizio, Iaccarino Ilaria, Canzano Federica and Di Lella Filippo, ENT and Otoneurosurgical Department, Parma University Hospital, Italy)

Chapter 8. The Retrosigmoid Approach: From the Microsurgical Anatomy to the Surgery
(Francesca Graziano, MD, Enrico Lo Bue, Lara Brunasso, MD, Alessia Lombardo, Rosario Maugeri, MD,
Domenico G. Iacopino, MD, PhD, Neurosurgical Clinic, AOUP "Paolo Giaccone", Postgraduate Residency Program in Neurosurgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, Palermo, Italy, and others)

Chapter 9. Middle Fossa Approach for Vestibular Shwannoma: An Overview
(Rosario Maugeri, Giuseppe Roberto Giammalva, Francesca Graziano, Teresa Somma, Carlo Gulì, Mariangela Pino and Domenico Gerardo Iacopino, Department of Experimental Biomedicine and Clinical Neurosciences, School of Medicine, Postgraduate Residency Program in Neurological Surgery, Neurosurgical Clinic, AOUP "Paolo Giaccone", Palermo, Italy, and others)

Chapter 10. Endoscopic Approach to Vestibular Schwannoma
(Daniele Marchioni, MD, and Davide Soloperto, MD, PhD, ENT Department, AOUI Verona, Verona University, Verona, Italy)

Chapter 11. Radiotherapy for Vestibular Schwannoma
(Gianluca Mortellaro, Giuseppe Ferrera, Francesco Cuccia and Filippo Alongi, Radiation Oncology Unit, ARNAS Ospedale Civico Di Cristina Benfratelli, Palermo, Italy, and others)

Chapter 12. Facial Nerve Restoration after Vestibular Schwannoma Surgery
(S. Taliente, M. Maruccia, R. Guarino, R. Elia, G. Giudice and Nicola Quaranta, Division of Otolaryngology, Department of BMS, Neuroscience and Sensory Organs University of Bari, Bari, Italy, and others)

Chapter 13. Vestibular and Proprioceptive Rehabilitation Strategy in Acoustic Neurinoma
(Valerio Giustino, Federico Sireci, MD, Giulia Letizia Mauro, MD, Giuseppe Messina, MD, Serena Rizzo, MD, and Francesco Martines, MD, PhD, Associate Professor, PhD Program in Health Promotion and Cognitive Sciences, University of Palermo, Palermo, Italy, and others)

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