Ventricular Arrhythmia: From Principles to Patients


Samuel C. Dudley, Ali A. Sovari and Abraham G. Kocheril (Editors)
West Hollywood, CA, USA

Series: Cardiology Research and Clinical Developments
BISAC: MED010000

Ventricular arrhythmias are the main cause of sudden arrhythmic death, a devastating situation that is tied to heart failure and its incidence is increasing despite current available therapies. This book reviews and explores the pathophysiology of ventricular arrhythmia and currently available therapeutic modalities including ion channel blockades, catheter ablation and defibrillators, with the hope that the wealth of accumulated science and knowledge have grown to the point that with the help of current advanced technology which allows targeting cellular, molecular and genetic components, a paradigm shift in treatment of these deadliest arrhythmias becomes possible. The book also provides chapters on currently available pharmacological options, defibrillation and catheter ablation as well as chapters on new treatments and technologies such as cell and gene therapies and what may be the future of arrhythmia therapy. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


1. Epidemiology of Ventricular Arrhythmia
(Amit Noheria and Sumeet S. Chugh, The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA)

2. Basic Mechanisms of Ventricular Arrhythmia: Focal Activity and Reentry
(Thomas K. Kurian, Wenwen Li, and Igor R. Efimov, Washington University in St. Louis, MO, USA)

3. Ventricular Arrhythmia in Structurally Remodeled Hearts and Potential Role of Myocardial Fibrosis
(Thomas H. Everett, IV and Jeffrey E. Olgin, University of California San Francisco, San Francisco, CA, USA)
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4. Ventricular Arrhythmia in Structurally Normal Hearts
(Charles Antzelevitch, and Jonathan M. Cordeiro, Masonic Medical Research Laboratory, Utica, NY, USA)

5. Role of Oxidative Stress in Ventricular Arrhythmias
(Ali A. Sovari, Oliver Small, Marcelo G. Bonini, Abraham G. Kocheril, and Samuel C. Dudley, The Center for Cardiovascular Research and the Section of Cardiology, University of Illinois at Chicago, Chicago, IL and others)
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6. Proteomics for Insights into Ventricular Arrhythmias
(Chad M. Warren and R. John Solaro, Department of Physiology and Biophysics and Center for Cardiovascular Research, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA)

7. Cell Therapy for Ventricular Arrhythmias & Ventricular Arrhythmias in Cell Therapy
(Fadi G. Akar and Ronald A. Li, The Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY, USA)

8. Gene Therapy for Ventricular Arrhythmias
(Tomonori Igarashi and J. Kevin Donahue, The Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University School of Medicine, Cleveland, OH, USA)

9. Gap Junctional Communication and Ventricular Arrhythmias
(Elena Dolmatova and Heather S. Duffy, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA)

10. Chaos in the Genesis of Ventricular Arrhythmias
(Zhilin Qu, Department of Medicine, Division Section of Cardiology, David Geffen School of Medicine at University of California, Los Angeles, CA, USA)

11. Autonomic Nervous System in Ventricular Arrhythmia
(Lan S. Chen, Peng-Sheng Chen, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA)

12. Microvolt T-Wave Alternans: From Molecule to Man
(Florian Rader, Michael J. Cutler, and David S. Rosenbaum, From the Heart and Vascular Research Center, Case Western Reserve University, MetroHealth Campus, Cleveland, OH, USA)

13. Mechanisms of Defibrillation
(Raymond E. Ideker, Vladimir Fast, Jack M. Rogers, and Steven Pogwizd, University of Alabama at Birmingham, Birmingham, AL, USA)

14. Pharmacological Options in Prevention of Ventricular Arrhythmia
(Renee M. Sullivan, Rakesh Gopinathannair, and Brian Olshansky, University of Iowa Hospitals, Iowa City, IA, USA and others)

15. Catheter Ablation of Ventricular Tachycardia
(Nilesh S. Mathuria, Roderick S. Tung and Kalyanam Shivkumar, UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA)

16. Therapies for Ventricular Arrhythmias: Future Directions
(Ali A. Sovari, Abraham G. Kocheril, Samuel C. Dudley, Section of Cardiology, and the Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL, USA)
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