Ventilator Induced Lung Injury in Non-Invasive Ventilatory Support: Pathophysiology, Treatment and Prevention

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Antonio M. Esquinas, MD, PhD, FCCP, FAARC – Intensive Care Unit Hospital Morales Meseguer, Murcia, Spain; Director International School of Non-Invasive Ventilation; Director International Non Invasive Ventilation Expert of College

Series: Pulmonary and Respiratory Diseases and Disorders
BISAC: MED119000; MED079000
DOI: https://doi.org/10.52305/CNAO0121

“Dr. Esquinas, an internationally known expert in the field, has put together an outstanding group of experts from around the globe to address the physiologic effects of non-invasive ventilation. This well-organized book truly covers the material in a well written easy to understand manner. This text exceptionally covers the concepts of biotrauma, lung mechanics, inflammatory cascades, barotrauma and the effects of atelectasis giving the reader a better understanding of adverse effects on the clinical and cellular level. It also addresses the aspects of the time course of use and how it will impact patients. The authors genuinely address these topics and through excellent editing material is reinforced throughout the book in a very clear manner. One very important topic that is covered in the text is self-induced lung injury as this is one of the few therapies widely used by patients at home. I believe this information can be used as a keystone of patient education. In summary, this textbook belongs in the library of every physician and respiratory therapist. It is an outstanding reference and will add greatly to the education of our students, residents, and fellows in the use of non-invasive ventilation.” To read the full review, click here.>>>Peter J. Papadakos MD FCCM FCCP FAARC FNIV, Director Critical Care Medicine, Professor Anesthesiology, Surgery, Neurology and Neurosurgery , University of Rochester, Rochester New York USA; Professor Medicine Mercer School of Medicine, Macon Georgia USA


This book describes the impact that can be had on treatments in patients with hypoxemic respiratory failure (pneumonia, acute respiratory distress syndrome, etc.) The impact that COVID-19 has had on a large number of patients treated and a large demand for these techniques. This book describes these treatment options and how they should be applied to avoid inducing damage or injury associated with the patient, a concept that has been called “patient self-inflicted lung injury”. This book discusses its importance in the prognosis and mortality of patients.

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Table of Contents

Preface

Ackowledgments

Chapter 1. Epidemiology
Inês Teixeira Farinha, MD
Department Pneumology, Pulmonology Department, Coimbra Hospital and University Centre, Coimbra, Portugal

Chapter 2. Dyspnea in Spontaneous Acute Lung Injury: Pathophysiology
Catarina Carvalho Cordes Amaral Barata, MD
Centro Hospitalar Lisboa Occidental, Lisboa, Portugal

Chapter 3. Lung Mechanics and Inflammatory Response
Laura Expósito Calamardo, MD
Department of Cardiology, Hospital Virgen de la Luz, Cuenca, Spain

Chapter 4. Barotrauma, Volutrauma and Atelectrauma: Pathophysiology
Rosana Mara da Silva1 and Thales Cantelle Baggio2
1Respiratory Physiotherapist, Hospital Municipal Health Department Jaraguá do Sul (SC), Brazil
2Physician, Cardiovascular Surgeon, Intensive Care Physician, Hospital Jaraguá and Hospital São José, Jaraguá do Sul (SC), Brazil

Chapter 5. Barotrauma, Volutrauma and Atelectrauma: Pathophysiology
Aneesa S. Shahul1, MD, DM, DNB, EDARM, MRC and B. L. Parvathi2, MD
1Respiratory Medicine, Consultant Pulmonologist, AHRI, India
2Pulmonology Department, ESI Hospital, India

Chapter 6. Positive End-Expiratory Pressure and Ventilator-Induced Lung Injury: Mechanisms and Clinical Recommendations
Greta Zunino, MD1,2, Denise Battaglini, MD1, Paolo Pelosi, MD1,2 and Patricia R.M. Rocco3
1Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy
2Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy
3Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

Chapter 7. Time Course of Ventilator-Induced Lung Injury
Fernanda Ferreira Cruz1, MD, PhD, Paolo Pelosi2,3, MD and Patricia R.M. Rocco1, MD, PhD
1Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
2Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy
3Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy

Chapter 8. Hyperoxic Acute Lung Injury: Pathophysiology
Martina Flora, MD, Anna Annunziata, MD, Lidia Atripaldi, MD and Giuseppe Fiorentino, MD
Division of Respiratory Physiopathology and Rehabilitation, A.O.R.N. “Dei Colli” – Monaldi Hospital, Naples, Italy

Chapter 9. Ventilatory Approaches and High-Flow Nasal Cannula: Clinical Implications
Dimitrios A. Lagonidis, MD, PhD
Intensive Care Unit German Oncologic Center, Limassol, Cyprus

Chapter 10. Ventilatory Mode Approaches
Mario Agreda Fernández, MD
Medical Health Science, Emergency Department, Hospital Universitario Ramón y Cajal., Madrid, Spain

Chapter 11. High Frequency Non-Invasive Ventilation
Deniz Heppekcan, MD
Intensive Care Department, Darica Farabi Training and Education Hospital Kocaeli, Turkey

Chapter 12. A Summary of Animal Studies and Clinical Implications
Alejandro Úbeda Iglesias1, MD, PhD and Irene Fernández Burgos2, MD
1Intensive Care Unit, Hospital Punta de Europa, Algeciras, Spain
2Intensive Care Unit, Hospital Regional Universitario de Málaga, Málaga, Spain

Chapter 13. Pathophysiology, Treatment and Prevention
Lucía Hinojosa Díaz, MD
Emergency Department, Río Hortega Hospital, Valladolid, Spain

Chapter 14. Non-Invasive Negative Pressure Ventilation and Prevention of Lung Injuries
Mohammad Sallam1, MD, Nikhil Patankar2, MD and Omar Alibrahim3, MD
1Boston Children’s Hospital, Harvard Medical School, Department of Pediatrics Boston, Massachusetts, USA
2Beacon Children’s Hospital, Beacon Health System, South Bend, Indiana, USA
3Duke University Medical Center, Duke Children’s Hospital, Department of Pediatrics, Division of Pediatric Critical Care Medicine, Durham, North Carolina, USA

Chapter 15. Ventilator-Induced Lung Injury in Preterm Infants
M. O’Reilly1,2, PhD, and G. M. Schmölzer1,2, MD, PhD
1 Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, Alberta, Canada
2 Department of Paediatrics, University of Alberta, Edmonton, Alberta, Canada

Chapter 16. Management and Prevention of Ventilator Lung Injury in Children and Neonates with CPAP
Mariana Miranda1, MD, Rebecca Mitting1, MbCHB MRCPCH and Padmanabhan Ramnarayan1,2, MD PhD
1Pediatric Intensive Care Unit, St. Mary’s Hospital, Imperial College Healthcare NHS Trust, London, UK
2Imperial College, London, UK

Chapter 17. Surfactant Therapy in Prevention of Lung Injury in Neonates
Erika Pineda1, MD, Hari Gourabathini2, MD and Omar Alibrahim3,4, MD
1Oishei Children’s Hospital, University of Buffalo, Department of Pediatrics, Division of Pediatric Critical Care Medicine, Buffalo, New York, USA
2Beacon Children’s Hospital Beacon Health System, South Bend, Idiana, USA
3Duke University Medical Center
4Duke Children’s Hospital, Department of Pediatrics, Division of Pediatric Critical Care Medicine, Durham, North Carolina, USA

Chapter 18. Lung-Protective Ventilation Strategies in Preterm Infants
M. O’Reilly1,2, PhD and G. M. Schmölzer1,2, MD, PhD
1Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, Alberta, Canada
2Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada

Chapter 19. Biological Markers of Ventilator-Associated Lung Injury: Experimental and Clinical Studies
Ricardo Belo Quita, MD
Pneumology Department, Centro Hospitalar e Universitário do Porto, Portugal

Chapter 20. Monitoring Techniques: The Pressure/Volume Curve
Riccardo La Rosa, MD, Savino Spadaro, MD, PhD and Gaetano Scaramuzzo, MD
Department of Translational Medicine, University of Ferrara, Ferrara, Italy

Chapter 21. Non-Invasive Ventilatory Support and Patient Self-Induced Lung Injury: Pathophysiology
Nermin Zerman, MD
Ahi Evran University Training and Research Hospital, Kirsehir, Turkey

Index


Editor’s ORCID iD

Antonio M. Esquinas0000-0003-0571-2050

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