Vascularization and its Role in Medicine and Tissue Engineering


Emre Bulbul, MD – Department of Urology, Vakfikebir State Hospital/Trabzon, Turkey
Murat Oguz Ozilhan, MD – T.C. Ministry of Health Ankara City Hospital, Ankara, Turkey

Series: Medical Procedures, Testing and Technology
BISAC: MED003040; MED009000

This book provides comprehensive information to all medical doctors regarding novel angiogenic and bioengineering medical treatments. Tissue healing is significantly hampered by ineffective neovascularization at the site of the defect, resulting in poor clinical outcomes. The fabrication of biomaterial-based scaffolds with adequate vascularizing abilities is the prevailing challenge that has drawn considerable attention from the scientific community. The decisive roles of vascularized biomaterials as bone and skin substitutes, and in various soft and hard tissue engineering, have been investigated widely.

Cell-based and scaffold encapsulating bioactive molecules-based approaches are essential means of developing efficient angiogenesis in tissue defects. To fulfill the necessity of an optimum long-term vascularizing scaffold, it should essentially be economic, controlled, and reproducible. While a lot has been achieved towards acknowledging newer molecules with vascularizing abilities; there is a broad gap wherein we need to develop in vitro vascularized implants as well as tissues and organs with the advanced technologies and knowledge at our disposal.

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Table of Contents


Chapter 1. Biomolecules for Triggering Vascularization in Soft and Hard Tissue Healing
Pratik Das1, Sonali Jana2, Piyali Basak1, Biswanath Kundu3 and Samit Kumar Nandi2
1School of Bioscience & Engineering, Jadavpur University, Kolkata, India
2West Bengal University of Animal & Fishery Sciences, Kshudiram Bose Sarani, Kolkata, India
3Bioceramics and Coating Division, CSIR-Central Glass and Ceramic Research Institute, Kolkata, India

Chapter 2. The Role of Oxygenation in Tissue Engineering
Aysegul Gencer, MD
Istanbul Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Department of Chest Diseases, Istanbul, Turkey

Chapter 3. Vascular Development, Its Genetic Control, and Effects on Diseases
Ugur Gumus, MD
Department of Medical Genetics, Gaziantep Dr. Ersin Arslan Training and Research Hospital, Gaziantep, Turkey

Chapter 4. Vascularization and Infection
Oguz Evlice1, MD
Department of Infectious Diseases and Clinical Microbiology, Kutahya University of Health Sciences School of Medicine, Kutahya, Turkey

Chapter 5. Vascularization in COVID-19 Sepsis
Zubeyir Sivrikaya, MD
Trabzon Kanuni Training and Research Hospital, Department of Anesthesiology, Trabzon, Turkey

Chapter 6. Vascularization and Cardiovascular Diseases
Esra Kansu Dinc, MD
Dr. Halil İbrahim Özsoy Bolvadin State Hospital, Department of Cardiology, Afyonkarahisar, Turkey

Chapter 7. The Effect of Vascular Function on the Musculoskeletal System
Mehmet Ali Dursun
Vakfıkebir State Hospital, Department of Orthopaedics and Traumatology, Trabzon, Turkey

Chapter 8. Angiogenic Therapies, Tissue Implantations, and Tissue Engineering in Urology
Emre Bulbul1, MD and Yavuz Ilki2, MD
1Trabzon Vakfikebir State Hospital, Department of Urology, Trabzon, Turkey
2Gulhane Training and Research Hospital, Department of Urology, Ankara, Turkey


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