Uterine Fibroids: From Diagnosis to Treatment


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Series: Obstetrics and Gynecology Advances

BISAC: MED033000

Uterine fibroids (UFs) are benign masses that develop from the smooth muscle cells and connective tissue of the wall of the uterus under the influence of genetic and / or hormonal stimuli.  These benign tumors are postulated to arise from a single, genetically altered, mesenchymal cell under the influence of gonadal hormones namely progesterone and 17𝛽-estradiol. The annual societal cost for fibroids is estimated up to 34 billion dollars, calculated through combined expenditures for medical management of symptomatic fibroids, lost work attributable to diagnosis of fibroids, and obstetrical complications of fibroids In Italy, for example, they afflict 3 million women.  Estimates say that 20 to 80% of women experience them throughout life, and are the most common form of benign cancer in childbearing age.

Various surgical and medical options are currently available to manage symptomatic uterine fibroids. The choice of the appropriate therapeutic approach for UFs depends on several factors, including women’s age, parity, childbearing aspirations and wish to preserve fertility, extent and severity of symptoms, size, number and location of myomas, risk of malignancy and proximity to menopause.
This book reviews the diagnoses, management and treatment of uterine fibroids.

Table of Contents



Chapter 1. Imaging Features of Myometrium and Uterine Masses
(Silvia Gemmiti, MD, Houssein El Hajj, MD, Chiara Benedetto, PhD, Stephanie Anne Sophie Gentile, MD, and Donatella Tota, MD – Obstetrics and Gynecology 1U, Department of Surgical Sciences, Sant’Anna Hospital, University of Turin, Turin, Italy, et al.)

Chapter 2.  Impact, Management, and Treatment of Uterine Myomas in Infertile Couples
(Andrea Carosso MD, Alessandro Ruffa MD, Noemi Mercaldo MD, Bernadette Evangelisti MD, and Alberto Revelli PhD- Gynecology and Obstetrics 1U, Pathophysiology of Reproduction and IVF Unit, Department of Surgical Sciences, Sant Anna Hospital, University of Torino, Turin, Italy)

Chapter 3.  Uterine Fibroids and Pregnancy: Last Insights
(Alessandra Carosi, Giovanni Ruspa, MD and Marta Tosi – SC Ostetricia e Ginecologia, Ospedale SS Trinità, Borgomanero, Italy)

Chapter 4.  Medical Treatment of Uterine Fibroids
(Maria Grazia Baù, MD, and Alessandra Surace, MD – SCDO Ginecologia ed ostetricia 3, Sant’Anna Hospital, Città della salute e della Scienza, Turin, Italy, et al.)

Chapter 5. Surgical Treatment for Uterine Fibroids
(Livio Leo, MD, Stephanie Challancin, MD,  Raphael Thomasset, MD and Nicole Brunod, MD – Obstetrics and Gynecology Department, Beauregard Hospital, Aosta, Italy)

Chapter 6.  Postoperative Care after Myomectomy Surgery
(Chiara Ferrari and Giuseppina Poppa – Emergency Department, S. Anna Hospital, University of Torino, Turin, Italy)

Chapter 7.  Uterine Artery Embolization: The Interventional Radiologist Point of View
(Andrea Paladini, MD, Pietro Danna, MD, Massimiliano Cernigliaro, MD, Giuseppe Guzzardi, MD, and Alessandro Carriero, MD, PhD – Department of Diagnosis and Treatment Services, Radiodiagnostics, Azienda Ospedaliero Universitaria Maggiore della Carità, Novara, Italy)

Chapter 8.  Uterine Smooth Muscle Tumor of Uncertain Malignant Potential
(Margerita Goia, MD, Maria Giulia Disanto, MD, Domenico Ferraioli, PhD and Andrea Palicelli, MD – Unit of Pathology, Città della Salute e della Scienza, Turin, Italy, et al.)


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