Table of Contents

Table of Contents

Preface

Part I: Pathophysiology, and Subtypes of Cerebral Small Vessel Disease

Chapter 1. Prevalence of Different Forms of Small-Vessel Disease in Vascular Cognitive Impairment
(Raquel Manso Calderón, MD, PhD, Department of Neurology, University Hospital of Salamanca, Salamanca, Spain)

Chapter 2. The Pathophysiological Mechanism of Cerebral Small Vessel Disease and Brain-Derived Proteins as Biochemical Markers
(Sergio González-García, PhD, Alina González-Quevedo, MD, PhD, Marisol Peña-Sánchez, Zenaida Hernández-Diaz, MD, Anay Cordero-Eiriz, Melany Betancourt-Loza, Caridad Menéndez-Saínz, PhD, and Rebeca Fernández-Carriera,“Dr. Miguel Enriquez” Faculty, Medical University of Havana, Havana, Cuba, and others)

Chapter 3. The Role of Nitric Oxide and Superoxide Anion Radical Cycles in Cerebral Small Vessels Pathology
(Valentin P. Reutov, PhD, DSc, Elena G. Sorokina, PhD, Lyudmila A. Davydova, PhD, Victor M. Chertok, MD, PhD, Oleg I. Sukmansky, MD, PhD, and Vsevolod G. Pinelis, MD, PhD, Institute of Higher Nervous Activity and Neurophysiology. Russian Academy of Sciences. Moscow, Russia, and others)

Part II: New Approaches for Diagnosis and Treatment of CSVD

Chapter 4. Microvascular Assessment in Cerebral Small Vessel Disease
(Kusum Sinha, PhD, and Kerstin Bettermann, MD, PhD, Department of Neurology, Penn State College of Medicine, Hershey, PA, US)

Chapter 5. Global Vision of Brain MRI Findings in Cerebral Small Vessel Disease
(Zenaida Milagros Hernández-Díaz, MD, Joshua P. Klein, MD, PhD, Sergio González-García, PhD, Alina González-Quevedo, MD, PhD, Marisol Peña-Sánchez and Armando Abreu Duque, Neuroradiology Department, International Center for Neurological Restoration, Havana, Cuba, and others)

Chapter 6. EEG in Cerebral Small Vessel Disease
(Marta Brown Martínez, MD, Department of Clinical Neurophysiology, Sport Medicine Institute, Havana, Cuba)

Chapter 7. Advanced Treatment Options for Cerebral Small Vessel Disease Assessed by Ultra-High-Field MRI Findings, and Autoimmune Biomarkers of Neurotoxicity
(Thomas A. Gennarelli, MD, Svetlana A. Dambinova, PhD, DSc, Mario Estevez Baez, MD, PhD, and John D. Mullins, MD, Medical College of Wisconsin. West Chester, PA, USA, George Washington University, Washington DC, USA, and others)

Chapter 8. Key Pathogenetic Mechanisms and Therapeutic Approaches to Modify the Course of Cerebral Small Vessel Disease
(Ella Yu. Solovyeva, MD, PhD, and Аndrey V. Сhekanov, PhD, Laboratory of Biomedical Studies in Neurology, Department of Neurology, Pirogov Russian National Research Medical University, Moscow, Russia)

Chapter 9. Neuroprotection in Cerebral Small Vessel Disease
(Julio César García Rodríguez, PhD, Yamila Rodríguez Cruz, MD, PhD, and Alina González-Quevedo, MD, PhD, CENPALAB, National Center for Animal Breeding, BioCubaFarma, Havana, Cuba, and others)

Part III: Potential Biomarkers for CSVD

Chapter 10. Detecting Asymptomatic Cerebral Small Vessel Disease. Brain Specific Proteins as Surrogate Biomarkers
(Alina González-Quevedo, MD, PhD, Sergio González García, PhD, Marisol Peña Sánchez, Zenaida Hernández Díaz, MD, María Caridad Menéndez Saínz, PhD, Rebeca Fernández Carriera, Anay Cordero Eiriz and Melany Betancourt Loza, Institute of Neurology and Neurosurgery, Havana, Cuba, and others)

Chapter 11. Circulating Inflammatory and Oxidative Stress Biomarkers in Subclinical Cerebral Small Vessel Disease
(Marisol Peña Sánchez, Alina González-Quevedo, MD, PhD, Zenaida Hernández Díaz, MD, and Sergio González García, PhD, Neurobiology Department, Institute of Neurology and Neurosurgery, Havana, Cuba, and others)

Chapter 12. Potential Biochemical Markers for Migraine and CSVD
(Svetlana А. Dambinova, PhD, DSc, Vladimir L. Beloborodov, PhD, DSc, Ivan I. Кrasnyuk, PhD, DSc, Мario Estevez Baez, MD, PhD, Gyuzyal R. Tabeeva, MD, PhD, DSc, Vladimir А. Parfenov, MD, PhD, DSc, Emory Decatur Hospital, Emory Healthcare, Decatur, GA, USA, and others)

Chapter 13. Assessment of Cognitive Impairment Due to CSVD Using Neuroimaging and Liquid Neurovascular Biomarkers
(Larisa A. Dobrynina, MD, PhD, DSc, Evgenia V. Alexandrova, MD, PhD, Maryam R. Zabitova, MD, Ludmila A. Kalashnikova, MD, PhD, DSc, Marina V. Krotenkova, MD, PhD, Elena V. Gnedovskaya, MD, PhD, DSc, Elena I. Kremneva, MD, PhD, and Bulat M. Akhmetzyanov, MD, N. N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia, and others)

Part IV: Cerebral Small Vessels Disease and Comorbid Conditions

Chapter 14. Endothelial Dysfunction Induced by Infectious Agents in Cerebral Small Vessel Disease
(Claudia O. Rodrigues, PhD, Cristiane M. De Leis, PhD and Andrew V. Oleinikov, PhD University of Miami Miller School of Medicine, Department of Molecular and Cellular Pharmacology, Miami, FL, USA, and others)

Chapter 15. Cerebral Vascular Disorders in COVID-19
(Anatoly I. Fedin, MD, PhD, DSc, and Svetlana A. Dambinova, PhD, DSc, Neurology Department of Russian National Research Pirogov Medical University, Moscow, Russia, and others)

Chapter 16. Interactive Effects of Vascular Disease, Cognitive Impairment, and Dementia
(Jorge J. Llibre-Guerra, MD, Neurology Department, Havana School of Medicine, Havana, Cuba)

Chapter 17. Particularities of Cerebral Small Vessel Disease in Schizophrenia
(Ileana Marinescu, PhD, Dragoş Marinescu, PhD, Liana Pauna-Cristian, MD, and Puiu Olivian Stovicek, PhD, Department of Psychiatry, University of Medicine and Pharmacy of Craiova, Romania, and others)

Chapter 18. The Risk of Cerebral Small Vessel Disease Due to Uncontrolled Alcohol Consumption
(Galina A. Izykenova, PhD, Svetlana A. Dambinova, PhD, DSc, Institute Pharmacy, I.M. Sechenov First Moscow State Medical University. Moscow, Russia, and others)

Part V: Conclusion

Chapter 19. Future Trends in Microangiopathy Diagnosis and Treatment
(Alina Gonzalez-Quevedo, MD, PhD, Svetlana A. Dambinova, PhD, DSc, Kerstin Bettermann, MD, PhD, Institute of Neurology and Neurosurgery, Havana, Cuba, and others)

Index