Type I Interferon in Autoimmune Diseases and its Clinical Applications

Yihong Yao (Editor)
Director/Head of Pharmacogenomics, Genetics/Bioinformatics, Translational Science, Boyds, MD, USA

Series: Immunology and Immune System Disorders
BISAC: MED044000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Autoimmune diseases such as systemic lupus erythematosus (SLE), Sjögren’s syndrome, psoriasis, scleroderma (SSc) and myositis are heterogeneous disorders that result from interactions between genetic and environmental factors. Type I interferons (IFNs), especially IFN-α/β, have multiple biological functions including anti-viral and anti-bacterial properties, immuno-modulation, anti-proliferation, and intensive studies over decades have also revealed important roles in autoimmunity and cancer. Sustained Type I IFN elevation has been implicated in immune responses against self-antigens and tissue damage, which has led to the hypothesis that type I IFN might play a critical role in the pathogenesis of some autoimmune and inflammatory diseases. This book provides an overview of many key topics surrounding type I IFNs, beginning with detailed discussion of the type I IFN signaling pathway, the interplay between components that regulate this pathway, its involvement in autoimmunity, and a detailed review of the roles of type I IFNs in a series of well characterized inflammatory and autoimmune diseases. (Imprint: Nova Biomedical )


List of Contributors


Chapter 1. Type I Interferon Signalling Pathway and its Regulation
(Xiaobing Luo, Yihong Yao and Nan Shen, Translational Sciences, MedImmune, LLC, Gaithersburg, MD, USA, and others)
Free Download Available

Chapter 2. Type I Interferons and Autoimmunity
(Jeremy Di Domizio and Wei Cao, Department of Immunology,
The University of Texas MD Anderson Cancer Center, Houston, TX, USA)

Chapter 3. Type I Interferons in Systemic Lupus Erythematosus
(Gary P. Sims, Daniel C. Rowe, Bo Chen and Ronald Herbst, Respiratory, Inflammation and Autoimmunity, MedImmune, LLC, Gaithersburg, MD, USA)
Free Download Available

Chapter 4. Type I Interferons in Sjögren’s Syndrome
(Zheng Liu, Bahija Jallal, Lars Rönnblom and Yihong Yao, Translational Sciences, MedImmune, LLC, Gaithersburg, MD, USA, and others)

Chapter 5. Type I Interferons in Systemic Sclerosis
(Robert Lafyatis, Zheng Liu and Yihong Yao, Boston University School of Medicine, Boston, MA, USA, and others)

Chapter 6. The Type I Interferon System in Rheumatoid Arthritis
(Cornelis L. Verweij and Saskia Vosslamber, VU University Medical Center, Amsterdam, The Netherlands)

Chapter 7. Type I Interferons in Psoriasis
(Zheng Liu, Wei Cao, James G. Kruger and Koustubh Ranade, Translational Sciences, MedImmune, LLC, Gaithersburg, MD, USA, and others)

Chapter 8. Type I Interferons in Dermatomyositis and Polymyositis
(Steven A. Greenberg, Department of Neurology, Division of Neuromuscular Disease, Brigham and Women’s Hospital, and Children’s Hospital Informatics Program, Harvard Medical School, Boston, MA, USA)

Chapter 9. The Interferon System in MS: Towards a Personalized Medicine Approach for Interferon-β Therapy
(Cornelis L. Verweij and Saskia Vosslamber, Department of Pathology, VU Medical Center, Amsterdam, The Netherlands)

Chapter 10. Developing Anti-Type I Interferon Therapy in Autoimmune Diseases and Personalized Medicine
(Brandon W. Higgs, Bahija Jallal and Yihong Yao, Translational Sciences, MedImmune, LLC, Gaithersburg, MD, USA)


"This is an important and timely resource of type I interferons and their relationship to autoimmune disease. The book fist addresses the basic biology of interferon signaling and gives the reader a firm grasp of the molecular machinery operating both upstream and downstream of the interferons." READ MORE... - Dr. David Fiorentino, an Associate Professor of Dermatology at Stanford University School of Medicine

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