Tumor Suppressors


Susan D. Nguyen (Editor)

Series: Cell Biology Research Progress, Cancer Etiology, Diagnosis and Treatments
BISAC: SCI008000

A tumor suppressor gene, or anti-oncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes. This book presents topical research data in the study of tumor suppressors, including Rab GTPases as potential tumor suppressors; the regulation of neutrophil function by tumor suppressor PTEN; the role of BRIT1/MCPH1 in genome maintenance and tumor suppression; epigenetic silencing of tumor suppressors; and the relationship between MicroRNA and tumor suppressors. (Imprint: Nova Biomedical )


Table of Contents

Table of Contents


Aflatoxin B1 and Acetaldehyde Mutational Patterns in the Tumour Suppressor Gene TP53: Experimental Fingerprints using a Functional Assay and Relevance to Human Cancer Aetiology
(Vincent Paget, Mathilde Lechevrel, François Sichel, GRECAN, Centre François Baclesse, ICORE, Université de Caen Basse-Normandie et Centre François Baclesse, Caen-cedex, France)

Curative Therapy for Terminal Cancer?
(Doug Dix, Department of Health Science, University of Hartford, West Hartford, Connecticut)

Breast Cancer Screening by Methylation Analysis of Tumor Suppressor Genes in Breast Fluid ^
(JS de Groot, KPM Suijkerbuijk, PJ van Diest, E van der Wall, Professor of Pathology)

Rab GTPases as Potential Tumor Suppressors
(Christelle En Lin Chua, Yishan Lim, Ee Ling Ng, Bor Luen Tang, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore)

Regulation of Neutrophil Function by Tumor Suppressor PTEN
(Subhanjan Mondal, Hongbo R. Luo, Department of Pathology, Harvard Medical School, Boston, Massachusetts, and others)

Wnt Pathway-Independent Activities of the APC Tumor Suppressor ^
(Jenifer R. Prosperi and Kathleen H. Goss, Department of Surgery, University of Chicago, Chicago, IL 60423)

Emerging Roles of BRIT1/MCPH1 in Genome Maintenance and Tumor Suppression
(Guang Peng, Shiaw-Yih Lin, Department of Systems Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA)

The Role of Histone Deacetylase (HDAC) and EZH2 in Oncogenesis: Epigenetic Silencing of Tumor Suppressors
(Junpei Yamaguchi, Motoko Sasaki, Yasuni Nakanuma, Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan)

Functions of Kank1 and Carcinogenesis
(Naoto Kakinuma, Yun Zhu, Takunori Ogaeri, Jun-ichiro Suzuki, Ryoiti Kiyama, Department of Anatomy and Cell Biology, Interdisciplinary Graduate School of Medicine & Engineering, University of Yamanashi, Tsukuba, Ibaraki, Japan, and others)

The Relationship between MicroRNA and Tumor Suppressors
(Douglus Wu, Mary Waye, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, N.T. Hong Kong)

Biomarkers for Radiosensitivity and Radiosensitization Targets in Prostate Cancer ^
(Weiwei Xiao, Peter Graham, Carl Power, Yong Li, Faculty of Medicine, University of New South Wales, Kensington NSW 2052, Australia)

Molecular Functions of the p53 Tumor Suppressor in the Apoptotic Response to DNA Damage ^
(Kiyotsugu Yoshida, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 113-8510, Japan)

How Does Tumor Suppressor FHIT Modulate Oxidative Stress and DNA Damage Checkpoints in Early Cancer?
(Hideshi Ishii, Toshiyuki Saito, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan, and others)*

Role of the Tumor Suppressor PDCD4 in the Differentiation of the Skin
(Sachiko Matsuhashi, Takeshi Okawa, Yutaka Narisawa, Department of Internal Medicine, Saga Medical Schoo, Saga University, Saga, Japan)*



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