Tumor Suppressor Genes: Functions, Regulation and Health Effects

Mehmet Gunduz, MD, PhD (Editor)
Faculty of Medicine, Turgut Ozal University, Ankara, Turkey

Esra Gunduz (Editor)

Series: Cancer Etiology, Diagnosis and Treatments, Genetics – Research and Issues
BISAC: MED000000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Cancer is a devastating disease lacking an exact treatment. Recent advances in genetics and biotechnology have provided a deeper understanding of cancer biology, out of which aberrations in oncogenes and tumor suppressor genes have arisen as important etiological factors. Inactivation of tumor suppressor genes is one of the initial cellular changes that ultimately lead to tumor development.

Thus increasing knowledge about these genes aids in the development of novel therapeutic applications as well as identification of more effective and rapid molecular markers for early diagnosis and prognostic evaluation. This book provides up-to-date information on the structure, function and roles of the main tumor suppressor genes thus far identified. An important addition to the current literature in the field, this book is intended to help instructors for teaching purposes and researchers in the field of cancer biology as an overview of current knowledge. (Imprint: Nova Biomedical )

Chapter 1. Physico-Chemical Properties of the Putative Tumor Suppressor Protein, 101F6
(Alajos Bérczi and Motonari Tsubaki, Institute of Biophysics, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary, and others)

Chapter 2. The Inhibitor of Growth (ING) Gene Family: Potential Use in Cancer Diagnostics and Therapy
(Mehmet Gunduz, Eyyup Uctepe, Catherine Moroski Erkul, Senol Dane and Esra Gunduz, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey)

Chapter 3. Multifunction New Tumor Suppressor Gene Family from Cancer to Metastasis: A Disintegrin and Metalloproteinases with Thrombospondin Motifs (ADAMTS)
(Kadir Demircan, Yunus Emre Bilgen, Tugrul Celik, Yudum Yaral, Birsen Dogan, Zisan Nur Akcaag, Zahide Nur Unal and Mehmet Gunduz, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey)

Chapter 4. Von Hippel–Lindau (VHL) Gene and Protein (pVHL): A Member of the Tumor Suppressor Gene Family
(Ferah Armutcu, Kadir Demircan and Murat Oznur, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey)

Chapter 5. Application of Cancer Gene Therapy Using Tumor Suppressor Gene p53
(Hiroshi Tazawa, Shunsuke Kagawa and Toshiyoshi Fujiwara, Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan, and others)

Chapter 6. p63 and p73: Members of the p53 Tumor Suppressor Family
(Zeynep Ocak, Murat Oznur, Ramazan Yigitoglu, Esra Gunduz and Mehmet Gunduz, Department of Medical Genetics, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey, and others)

Chapter 7. The Emerging Roles of Forkhead Box (FOX) Family Proteins in Tumor Suppression
(Pang-Kuo Lo, The Department of Biological Sciences, University of South Carolina, Columbia, SC, USA)

Chapter 8. Molecular Basis of BRCA1 and BRCA2 and Clinical Approaches to BRCA1/2 Mutation Carriers
(Kemal Keseroglu, Fatih Aydogan and Mustafa Ozen, Department of Medical Genetics, Istanbul University, Cerrahpasa Medical School, Istanbul, Turkey, and others)

Chapter 9. On The Verge of Being a Tumor Suppressor Gene or an Axonal Guidance Molecule: DCC
(Omer Faruk Karatas, Betul Yuceturk and Mustafa Ozen, Department of Medical Genetics, Istanbul University, Cerrahpasa Medical School, Istanbul, Turkey, and others)

Chapter 10. DKK3, a Mysterious Tumor Suppressor Gene that Possesses Multiple Functions in Tumor Progression
(Naoki Katase, Tsutomu Nohno and Mehmet Gunduz, Department of Molecular and Developmental Biology, Kawasaki Medical School, Okayama, Japan, and others)

Chapter 11. The Functions and Roles of the Unique Tumor Suppressor Gene PTEN
(Omer Faruk Karatas, Esra Guzel and Mustafa Ozen, Department of Medical Genetics, Istanbul University Cerrahpasa Medical School, Istanbul, Turkey, and others)

Chapter 12. Functions of the Tumor Suppressor Gene APC
(Tomoki Yamatsuji, Munenori Takaoka, Takuya Fukazawa and Yoshio Naomoto, Department of General Surgery, Kawasaki Medical School, Japan)

Chapter 13. Structure and Function of the Tumor Suppressor Gene p16
(Zeynep Tarcan, Catherine Moroski Erkul, Bunyamin Isik, Esra Gunduz and Mehmet Gunduz, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey, and others)

Chapter 14. The Functions and Roles of RB1 in Cancer
(Erkan Koparir, Asuman Koparir and Mustafa Ozen, Department of Medical Genetics, Istanbul University, Cerrahpasa Medical School, Istanbul, Turkey, and others)

Chapter 15. Endoplasmic Reticulum Protein 29 (ERp29) and Cancer: Molecular Functions, Mechanisms and Clinical Implication
(Daohai Zhang, Discipline of Pathology, School of Medical Sciences, University of Sydney, Sydney, Australia)

Chapter 16. Divergent Roles for Tumor Suppressor Genes in Cancer
(Marina Trombetta-Lima, Thiago Jacomasso, Sheila Maria Brochado Winnischofer and Mari Cleide Sogayar, Biochemistry Department, Chemistry Institute, University of São Paulo, São Paulo, Brazil, and others)

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