Tuberculosis: Risk Factors, Drug Resistance and Treatment


Scott E. Walker (Editor)
David F. Martin (Editor)

Series: Allergies and Infectious Diseases
BISAC: MED079000

The current resurgence of tuberculosis (TB) is being sustained and fueled by the increasing incidence of resistance of M. tuberculosis strains to the most-effective (first-line) anti-TB drugs and association of active TB disease with concomitant human immunodeficiency virus (HIV) infection or other underlying immunosuppressive conditions such as diabetes. In this book, the authors study the risk factors, drug resistance data and treatment methods for tuberculosis. Topics discussed include the global burden of TB and its public health crisis; new medicines to treat TB; rapid microcalorimetric detection of TB; meta-analysis and risk factors for tuberculosis susceptibility; Type 2 diabetes as a risk factor for TB; and elucidating the action mode of the bi-substrate InhA inhibitors as anti-tuberculosis agents through molecular dynamics simulations. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Tuberculosis: Risk Factors, Drug Resistance, Rapid Detection and Treatment
(Suhail Ahmad, Eiman Mokaddas, Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait)

New Medicines against Tuberculosis
(Ana Luisa de Jesus Lopes Ribeiro, Maria Rosalia Pasca, Giovanna Riccardi, Dipartimento di Biologia e Biotecnologie , Università degli Studi di Pavia, Pavia, Italy)

Rapid Microcalorimetric Detection of Tuberculosis: Developments to Date and Future Perspectives
(O. Braissant, G. Bonkat, A.U. Daniels, D. Wirz, A. Bachmann, Laboratory of Biomechanics and Biocalorimetry, LOB2, University of Basel, Basel, Switzerland, and others)

Meta-Analysis and Risk Factors for Tuberculosis Susceptibility
(Justin T. Denholm, Emma S. McBryde, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Australia)

Type 2 Diabetes as a Risk Factor for Tuberculosis
(Guadalupe García-Elorriaga, Guillermo del Rey-Pineda, Hospital de Infectología, Centro Médico Nacional La Raza (CMNR), Instituto Mexicano del Seguro Social (IMSS), México, and others)

Elucidating the Action Mode of the Bi-Substrate InhA Inhibitors as Anti-Tuberculosis Agents through Molecular Dynamics Simulations
(Auradee Punkvang, Pharit Kamsri, Dararat Kasamsri, Apinya Srisupan,
Patchreenart Saparpakorn, Supa Hannongbua, Peter Wolschann, Supakit Prueksaaroon, Pornpan Pungpo, Faculty of Liberal Arts and Sciences, Nakhon Phanom University Nakhon Phanom, Thailand, and others)

Enhancing Drug Target Identification in Mycobacterium Tuberculosis
(Gaston K. Mazandu, Nicola J. Mulder, Computational Biology Group, Department of Clinical Laboratory Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa)


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