Troponin: Regulator of Muscle Contraction

J.-P. Jin, MD, PhD (Editor)
Department of Physiology, Wayne State University School of Medicine, Michigan, USA

Series: Muscular System – Anatomy, Functions and Injuries
BISAC: SCI007000

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Muscle contraction is a vital biological activity. In three centuries of scientific pursuit since Leeuwenhoek and Croone observed the cellular structure of striated muscles, the knowledge gained from extensive studies has formed a detailed understanding of muscle function at the molecular and atomic level. Contractions of vertebrate skeletal and cardiac muscles are controlled by Ca2+ signaling through the troponin complex in the sarcomeres, which are contractile machinery consisting of interactive myofilaments.

Since the discovery and biochemical characterization of troponin and its three subunit proteins over four decades ago, intensive research from protein structure and genetic diversity to post-translational modification and pathological mutations have comprehensively established the molecular structure of troponin and the mechanistic details of its function in the regulation of muscle contractions. The advanced knowledge from troponin research has contributed significantly to the current understanding of cardiac and skeletal muscle function in health and diseases. It is a timely necessity to comprehensively, yet concisely, summarize the current knowledge and look toward the future direction of troponin research.

Contributions to this book have been made by leading experts in troponin studies, and its contents include chapters that describe milestone discoveries and recent research advances. This wonderful collection provides a unique reference for students and research investigators who have an interest in muscles, protein structure-function relationships and molecular evolution, as well as cardiac function and myopathies. Readers will not only obtain an in-depth state-of-the-science understanding of troponin structure and function, they will also be exposed to visions that will lead them toward future investigations and the advancement of troponin research.
(Imprint: Nova Biomedical )

Dedication

Preface

Chapter 1: A History of Troponin: An Adventure in the Complexities of Calcium-Dependent Regulation
(R. John Solaro, Department of Physiology and Biophysics and Center for Cardiovascular Research, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA)

Chapter 2: Troponin Isoform Diversity
(Peter J. Reiser, Department of Oral Biology, Ohio State University, Columbus, OH, USA)

Chapter 3: Evolutionary Lineage of Troponin Isoforms in Vertebrate Species
(J.-P. Jin, Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USA)

Chapter 4: Biochemical Functions of Troponin
(Sampath K. Gollapudi and Murali Chandra, Department of Integrated Physiology and Neuroscience, Washington State University, Pullman, WA, USA)

Chapter 5: Conformational States and Behavior of the Heterotrimeric Troponin Complex
(Daniel C. Rieck and Wen-Ji Dong, Washington State University, Pullman, WA, USA)
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Chapter 6: Kinetic Modeling of Troponin Dissociation in Striated Muscle
(Asok K. Sen, Richard G. Lugar Center for Renewable Energy and Department of Mathematical Sciences, Indiana University, IN, USA)

Chapter 7: Developmental and Adaptive Regulations of Troponin
(Han-Zhong Feng and J.-P. Jin, Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USA)

Chapter 8: Post-Translational Modification of Troponin
(Margaret Westfall, Department of Cardiac Surgery, University of Michigan, Ann Arbor, MI, USA)

Chapter 9: Role of Troponin in Length-Tension Relation
(Pieter P. de Tombe, Department of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood IL, USA)

Chapter 10: Troponin Abnormality and Systolic Function of the Heart
(Brandon J. Biesiadecki and Jonathan P. Davis, Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA)

Chapter 11: Cardiac Troponin Mutations: Diastolic Dysfunction and Therapeutic Options
(Pierre-Yves Jean-Charles, Changlong Nan, Lei Zhang, Jie Tian and Xupei Huang, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA, and others)

Acknowledgements

Index

"As part of his development of the Ca2+ concept of muscle contraction and relaxation in the 1960s, Setsuro Ebashi discovered the first intracellular Ca2+ binding protein which he named troponin. In 1971 Marion Greaser and John Gergely determined that troponin consisted of three subunits. They named the subunits based on their observed function: TnC bound Ca2+, TnI inhibited actomyosin ATPase activity in the presence or absence of Ca2+ and TnT bound to tropomyosin." READ MORE... - Jack A. Ralln, Ph.D., Department of Physiology & Cell Biology, Ohio State University

"The authors have provided an excellent review of the history of troponin-related studies as well as a comprehensive summary of the protein’s structure and function. Most of the key papers that have led to our currently understood concepts about this protein were summarized. There is considerable subject matter redundancy among the subtopics as often occurs in books with multiple authors, but the quality of the chapters is uniformly high. This book will be a valuable and up to date addition to the muscle protein literature." - Marion Greaser, University of Wisconsin-Madison, Madison, Wisconsin

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