Triple-Negative Breast Cancer: Biomarkers, Emerging Therapeutic Strategies and Clinical Challenges


Marion Montgomery (Editor)

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED009000

Poorly differentiated triple negative breast cancers (TNBCs) were first characterized in the literature in 2005 by the absence of receptors for estrogen (ER) and progesterone (PR) as well as the lack of tyrosine kinase human epidermal growth factor receptor 2 (HER-2). Clinically, TNBCs exhibit fairly aggressive local growth, rapid progression and account for a high rate of early metastases, most commonly to visceral organs and central nervous system. Chapter One describes how the last decade has contributed to our understanding of the function of exosomes in the progression of breast cancer. Furthermore, it will discuss the implications for using exosomes from body fluids as biomarkers in diagnosis and treatment strategies. Chapter Two discusses how the strong correlation between BRCA gene mutations and the high risk of TNBC proposes certain mediators between germline mutations and the risk for poorly differentiated breast cancers. Chapter Three presents increasing evidence of the role of tumor lymphocytic immune infiltrates in this subtype of breast cancer. High levels of tumor infiltrating lymphocytes (TILs), mainly in lymphocyte-predominant breast cancer (LPBC), have been associated with improved disease-free and overall survival rates in TNBC patients with and without any treatment. (Imprint: Nova Biomedical)

Table of Contents

Table of Contents


Chapter 1. The Role of Exosomes in Breast Cancer: What Have We Learned in Ten Years?
Belinda M. D’Costa, Naima Moustaid-Moussa and Lauren S. Gollahon (Department of Biological Sciences, Texas Tech University, Lubbock, Texas, USA, and others)

Chapter 2. Correlations between BRCA Gene Mutations and the High Risk of TNBC as Defined by the Defect of Estrogen Signaling
Zsuzsanna Suba (National Institute of Oncology, Surgical and Molecular Tumor Pathology Center, Budapest, Hungary)

Chapter 3. The Role of Tumor Infiltrating Lymphocytes (TILs) in Triple Negative Breast Cancer (TNBC)
Paula García-Teijido, María Muñiz Castrillo, María Luque Cabal, Ignacio Peláez Fernández and Yolanda Fernández Pérez (Department of Medical Oncology; Hospital Universitario San Agustín, Avilés, Spain, and others)


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