Treatment-Resistant Depression (TRD): Pharmacological Approaches, Challenges and Future Directions

Deborah Diaz (Editor)

Series: Psychiatry – Theory, Applications and Treatments
BISAC: MED105000

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Major Depressive Disorder (MDD) is a common and debilitating neuropsychiatric disorder with high economic and societal impact. Approximately 30% of subjects with MDD achieve full remission after treatment with conventional antidepressants resulting in a relevant percentage of patients suffering from treatment resistant depression (TRD). Treating TRD is a difficult challenge for psychiatrists due to the complexity of this disabling condition. In fact, TRD is generally associated with a poorer outcome, higher suicidal risk, more severe psychosocial impairment and physical disability when compared to MDD. This book provides new research on treatment options, challenges and the future directions for individuals with TRD. (Imprint: Nova Biomedical)

Preface

Chapter 1. Development and Validation of Pre-Clinical Models of Treatment-Resistant Depression
Stephen W. White and Kenneth J. Sufka (Department of Psychology, University of Mississippi, Oxford, MS, USA, and others)

Chapter 2. New Compounds for Treatment Resistant Depression: Ketamine and other Glutamatergic Agents
Gianluca Serafini, Giulia Adavastro, Michele Bugliani, Mehdi Ghasemi, and Mario Amore (Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy, and others)

Chapter 3. Drug Treatment of Severe Depression in Pregnancy: Focus on Serotonin Reuptake Inhibitors (SRIs)
Cesario Bellantuono, Alessandro Valchera, Domenico De Berardis, and Laura Orsolini (DEGRA Clinic for Perinatal Affective Disorders, Verona-Rimini-Ancona, Italy, and others)

Bibliography

Index

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