Translational Research: Recent Progress and Future Directions

Francesco Chiappelli, Ph.D. (Editor)
University of California at Los Angeles School of Dentistry, California State University, Northridge, CA, USA

Nicole Balenton (Editor)
UCLA Center for the Health Sciences School of Nursing, Los Angeles, CA USA

Series: Health Care in Transition
BISAC: HEA028000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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The future of healthcare lies in the continued progress and acceleration of adopting translational science. The two principal constructs, translational research and translational effectiveness, collectively strive towards patient-centered, effectiveness-focused and evidence-based care. Translational research is the application of scientific methods into healthcare decision-making and practice. Through these applications and methods used on the patient, translational research obtains new information that directly benefits that patient in return. This bench-to-bedside approach is specifically designed to improve health outcomes and standards of practice in healthcare to better serve the patients. It is through the utilization, dissemination, and implementation of the best evidence-based practices that will help in the understanding of intervention effectiveness.

The chapters in this book highlight the transfer of basic science discovered and cutting-edge developments into clinical applications. Emphasis on continuing research, increasing transparency and accelerating the adoption of translational science into clinical practice is needed to provide the best possible care. The chapters focus on the future direction of all fields of healthcare which lies on the bench-to-bedside approach – from medicine to dentistry to nursing. Translational research is at the forefront of efforts to improve patient care and is the engine of change for bringing new decision-making, practice, and technology into the field of healthcare in this new age.


Chapter 1. Translational Research and Effectiveness: Going Forward into the 21st Century
(Francesco Chiappelli , Nicole Balenton and Allen Khakshooy, Division of Oral Biology and Medicine, UCLA School of Dentistry, LA, CA, US)

Chapter 2. Advances in the Management of Merkel Cell Cancer
(Philip Friedlander, MD, PhD, and Corazon B. Cajulis, Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine, Mount Sinai Hospital, New York, NY, US, and others)

Chapter 3. The Intersection of Ethics and Translational Science
(Ian D. Coulter, Division of Public Health and Community Dentistry, UCLA School of Dentistry, LA, CA, US)

Chapter 4. Towards Comparative Effectiveness of Treatments for Dental Anxiety in Adult Patients: A Mixed Systematic Review
(Benjamin Garai, Nicole Balenton and Francesco Chiappelli, Division of Oral Biology and Medicine, UCLA School of Dentistry, LA, CA, US)

Chapter 5. Comparative Effectiveness Research of Dentin Hypersensitivity Intervention – A Mixed Systematic Review Analysis
(Nouf A. Alaskar and Francesco Chiappelli, University Staff Clinic, Dental University Hospital, School of Dentistry, King Saud University, Riyadh, Saudi Arabia)

Chapter 6. Comparative Effectiveness Research for Direct Pulp Capping Materials
(Khaled Alghulikah, Angela Du, Edward Hewlett, Carl Maida and Francesco Chiappelli)

Chapter 7. Zinc Metabolism in Exercise: Translating Research Findings to Maximise Physical Performance
(Anna Chu and Samir Samman, Department of Human Nutrition, University of Otago, Dunedin, New Zealand, and others)

Chapter 8. Fall Prevention and Reduction
(Ma. Angelina Begonia, Jamaica Hospital Medical Center, Jamaica, NY, US, and others)

Chapter 9. What is Lynch Syndrome?
(Corazon B. Cajulis, Mount Sinai Hospital, Madison Avenue, NY, NY, US)

Chapter 10. Natural Killer Cells Pave the Road for Effective Targeting of Cancer: Inhibition of Their Effector Function at the Pre-Neoplastic and Neoplastic Stage of Tumorigenesis
(Anahid Jewett, Janko Kos, Mengwei Ko, Tahmineh Safaei, Omid Nikjah, Majed Bamatraf, Paul Wong, Artin Keshishian Namagerdi and Kawaljit Kaur, Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, UCLA, Los Angeles, CA, US, and others)

Chapter 11. Emerging Technology for Screening of Oral Cancer
(Peter A. Pellionisz , Sabrina Levy, Jingfeng Liang, Nikan Namiri, Harrison Cheng, Yong Hu, Karam Badran, Diana Messadi, Zachary Taylor, Maie A. St. John and Warren Grundfest, Center for Advanced Surgical and Interventional Technology at Dept. of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, US)

Chapter 12. MicroRNAs: A New Perception for the Diagnosis and Treatment of Cancers Associated with Risk Factors
(Natália Cruz e Melo and Rafael Malagoli Rocha, Gynecologic Department, Federal University of São Paulo, Brazil)

Chapter 13. Harnessing Big Data for HIV/AIDS: Hypes and Hopes
(Nicola Luigi Bragazzi, Luca Giacomelli, Naim Mahroum and Roberto Eggenhöffner, University of Genova, Postgraduate School of Public Health (DISSAL), Genova, Italy)

"From renowned academic researchers to assiduous healthcare practitioners,this book wonderfully presents their pragmaticapproaches in fields of nursing, dentistry, medicine, bioethics, and public health." READ MORE... - Allen M. Khakshooy, MPH, MD Candidate, Technion – Israel Institute of Technology, Haifa, Israel

· Translational research
· Translational healthcare

Audience: Healthcare professionals (doctors, dentists, nurses, etc.), students and professors (undergraduate and graduate), researchers

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