Toxoplasma gondii: Biology and Role in Health and Disease



: Parasites and Parasitic Diseases
BISAC: SCI045000

Toxoplasma gondii is a globally spread protozoan parasite responsible for causing toxoplasmosis. Infection by T. gondii shows high seroprevalence in humans, especially in South America. Written by specialists, this book brings important contributions and information on parasite biology, including its life cycle, ultrastructural features of tachyzoite, bradyzoite and their main specific organelles, mechanisms of host cell invasion, parasite replication and epigenetics regulation. Moreover, the book will encompass mechanisms of pathogenesis and host immune response to the infection, including purinergic signaling, and mechanisms of immune evasion by the parasite. Finally, this book also addresses relevant aspects of disease, information about the current chemotherapy of toxoplasmosis and perspectives for a future chronic disease treatment, epidemiology, and methods for visualization of the parasite by optical and electron microscopy.

Table of Contents


Chapter 1. Toxoplasma gondii: Introduction to Parasite Life Cycle and Disease
(Lindice Mitie Nisimura, Thaís Cabral Monica and Andréa Rodrigues Ávila – Laboratório de Pesquisa em Apicomplexa, Instituto Carlos Chagas, Fundação Oswaldo Cruz, Paraná, Brazil)

Chapter 2. Ultrastructure of Tachyzoite, Sporozoite and Bradyzoite Forms
(Marcia Attias and Wanderley de Souza – Instituto de Biofísica Carlos Chagas Filho, Centro Nacional de Biologia Estrutural e Bioimagem, Universidade Federal do Rio de Janeiro, RJ, Brazil)

Chapter 3. Toxoplasma Gondii Entry Mechanisms and Establishment of the Parasitophorous Vacuole
(Juliana de Araujo Portes and Wanderley de Souza – Instituto de Biofísica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil)

Chapter 4. Cystogenesis Process in Toxoplasma Gondii
(Rossiane Claudia Vommaro, Marcia Attias and Wanderley de Souza – Laboratório de Ultraestrutura Celular Hertha Meyer, Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, Rio de Janeiro, RJ, Brazil, et al.)

Chapter 5. Toxoplasma Gondii Cell Division: Back To The Source
(Maria E. Francia – Laboratory of Apicomplexan Biology, Institut Pasteur de Montevideo, Montevideo, Uruguay)

Chapter 6. Epigenetic Regulation Affects Essential Mechanisms in Toxoplasma Gondii
(Caroline de Moraes de Siqueira, Julia Schwartz, Mariana Sayuri Ishikawa Fragoso, Vanessa Rossini Severo and Sheila Cristina Nardelli – Instituto Carlos Chagas, Fundação Oswaldo Cruz-Fiocruz, Curitiba, Paraná, Brazil)

Chapter 7. The Balance Between Host Cell-Autonomous Immunity and Toxoplasma Gondii Evasion Strategies
(Gabriel R. A. Cabral, Tâmara C. G. Ribeiro and Renato A. DaMatta – Universidade Estadual do Norte Fluminense Darcy Ribeiro, RJ, Brazil)

Chapter 8. Purinergic Signaling in the Host Resistance to Toxoplasma Gondii Infection
(Aline C. A. Moreira-Souza, Thuany P. Rangel, Sthefani R.B. Silva and Robson Coutinho-Silva – Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil)

Chapter 9. Metastatic-Like Phenotype of Monocytes/Macrophages Induced by Toxoplasma Gondii Infection: MMPS, UPA/UPAR and CD147 Involvement at Early Infection and Dissemination
(Andrea Cristina Vetö Arnholdt, Pollyana M. Oliveira Pimentel and Thaís Rigueti Brasil – Laboratório de Biologia do Reconhecer, Universidade Estadual do Norte Fluminense, Campos dos Goytacazes, RJ, Brazil)

Chapter 10. Over the Top: Arm Wrestling Between Toxoplasma Gondii and Host Skeletal Muscle Tissue
(Paloma de Carvalho Vieira, Helene Santos Barbosa and Daniel Adesse – Laboratório de Biologia Estrutural, Instituto Oswaldo Cruz – Fiocruz, Rio de Janeiro, Brazil)

Chapter 11. Current Treatment of Toxoplasmosis
(Érica dos Santos Martins-Duarte – Department of Parasitology, Federal University of Minas Gerais, Brazil)

Chapter 12. Advances in the Development of Treatments for the Chronic Phase of Toxoplasmosis
(Diego Rodney Rodrigues de Assis and Érica dos Santos Martins-Duarte – Departament of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil)

Chapter 13. Prevalence of Toxoplasma Gondii Infection in South America
(Gabriella de Lima Bessa, Ricardo Wagner de Almeida Vitor and Érica dos Santos Martins-Duarte – Laboratório de Toxoplasmose, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil)

Chapter 14. Cerebral Toxoplasmosis in People Living with HIV/AIDS
(Jose Ernesto Vidal and Vera Lucia Pereira-Chioccola – Departamento de Moléstias Infecciosas e Parasitárias, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, et al.)

Chapter 15. Toxoplasma Gondii: Ocular Disease
(Cristina Muccioli, Heloisa Nascimento, Carlos Eduardo de Souza and Alléxya Affonso Antunes Marcos – Department of Ophthalmology and Visual Sciences, Paulista School of Medicine -Federal University of São Paulo, São Paulo, SP, Brazil, et al.)

Chapter 16. Imaging Techniques in the Study of Toxoplasma Gondii
(Mario Del Rosario and Leandro Lemgruber – Instituto Gulbenkian Ciência, Oiras, Portugal, et al.)


Editor’s Orchid ID

Erica S. Martins-Duarte
Daniel Adesse –

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