$0.00
Mehfuz Zaman (Editor)
Mariusz Skwarczynski (Editor)
Istvan Toth (Editor)
The University of Queensland, Queensland, Australia
Series: Cell Biology Research Progress
BISAC: SCI017000
Toll-like receptors (TLRs) which recognise pathogen associated molecular patterns (PAMPs) are a vital link between the innate and adaptive immunity. TLR-mediated activation of dendritic cells (DCs) is a crucial step in triggering adaptive immunity as DCs are the principal initiator and modulator of the immune response.
With the advent of well-defined synthetic lipid moieties that structurally represent PAMPs, it is now possible to design synthetic vaccines containing disease-specific epitopes. This new book provides a brief overview of why DCs represent a crucial target and tool for vaccination and TLR mediated DC activation efficiently stimulates immune responses. (Imprint: Nova Biomedical)
Table of Contents
Abstract
Introduction
Initiation of an Immune Response
Dendritic Cells: The Doorway to Adaptive Immunity
TLRs: Key to Doorway of Adaptive Immunity
TLR Activation and Initial Effect on APCs
Bacterial Lipoproteins Represent TLR2 PAMPs
Lipopeptides and Mechanism of Action
Lipopeptides Based on Synthetic Analogues of Bacterial Lipoproteins
Palmitoylated Peptides
Lipopeptides Based on Lipoamino Acids
Conclusion
References
Index
We publish over 800 titles annually by leading researchers from around the world. Submit a Book Proposal Now!
