Toll-like Receptor 2 Mediated Dendritic Cell Activation Key Target for Lipopetide Vaccines Design

Mehfuz Zaman (Editor)
Mariusz Skwarczynski (Editor)
Istvan Toth (Editor)
The University of Queensland, Queensland, Australia

Series: Cell Biology Research Progress
BISAC: SCI017000

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Volume 10

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Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Toll-like receptors (TLRs) which recognise pathogen associated molecular patterns (PAMPs) are a vital link between the innate and adaptive immunity. TLR-mediated activation of dendritic cells (DCs) is a crucial step in triggering adaptive immunity as DCs are the principal initiator and modulator of the immune response.

With the advent of well-defined synthetic lipid moieties that structurally represent PAMPs, it is now possible to design synthetic vaccines containing disease-specific epitopes. This new book provides a brief overview of why DCs represent a crucial target and tool for vaccination and TLR mediated DC activation efficiently stimulates immune responses. (Imprint: Nova Biomedical)

Abstract

Introduction

Initiation of an Immune Response

Dendritic Cells: The Doorway to Adaptive Immunity

TLRs: Key to Doorway of Adaptive Immunity

TLR Activation and Initial Effect on APCs

Bacterial Lipoproteins Represent TLR2 PAMPs

Lipopeptides and Mechanism of Action

Lipopeptides Based on Synthetic Analogues of Bacterial Lipoproteins

Palmitoylated Peptides

Lipopeptides Based on Lipoamino Acids

Conclusion

References

Index

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