Thrombotic Thrombocytopenic Purpura: Causes, Diagnosis and Treatment

Mason Hillam (Editor)

Series: Recent Advances in Hematology Research
BISAC: MED038000

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Thrombotic thrombocytopenic purpura is a life-threatening occlusive disorder of the microcirculation that is characterized by systemic platelet agglutination, organ ischaemia, severe thrombocytopenia and fragmentation of red blood cells. In the opening study included in Thrombotic Thrombocytopenic Purpura: Causes, Diagnosis and Treatment, the authors analyze the principal risk factors and causes of this disorder.

Thrombotic thrombocytopenic purpura is diagnosed using standard laboratory tests: in addition to microangi-opathic hemolytic anemia and consumption thrombocytopenia, classical parameters for hemolysis show an elevated reticulocyte count, an undetectable serum haptoglobin concentration, and a markedly elevated lactate dehydrogenase level as well as the presence of schistocytes on the blood smear.

The authors propose that there are other pathologies with moderate thrombocytopenia that we should consider, such as: hereditary thrombotic thrombocytopenic purpura, hereditary hemolytic uremic syndrome, and thrombotic microangiopathies associated with some medications, transplantation or hidden malignancies.

The closing chapter aims to revise the management of thrombotic thrombocytopenic purpura in pregnant women. To effectively manage this disorder, it is crucial to obtain a prompt diagnosis, in conjunction with further monitoring and treatment, to avoid fetal loss and maternal complications.
(Imprint: Nova Medicine and Health)

Preface

Chapter 1. Causes and Risk Factors for Thrombotic Thrombocytopenic Purpura
(Llanos Belmonte Andújar, MD, Yanira Romero Sierra, MD, Esther López del Cerro, MD, Ana Dolores del Rey Luján, MD, and Carmen Cristina Amorós Pérez, MD, Obstetrics and Gynecology Department. Hospital of Almansa, Albacete, Spain, and others)

Chapter 2. Diagnosis of Thrombotic Thrombocytopenic Purpura
(Ana Dolores Del Rey Luján, MD, Carmen Cristina Amorós Pérez, MD, Llanos Belmonte Andújar, MD, Lorena Pico Rico, MD, Martin Antonio Cabero Becerra, MD, Hematology and Hemotherapy. Hospital of Alcázar de San Juan, Ciudad Real, Spain, and others)

Chapter 3. Differential Diagnosis and Treatment of Thrombotic Thrombocytopenic Purpura
(Martín Antonio Cabero Becerra, MD, Lorena Picó Rico, MD, Ana Dolores Del Rey Lujan, MD, Carmen Cristina Amorós Pérez, MD, Llanos Belmonte Andújar, MD, Hematology and Hemotherapy. Hospital of Alcázar de San Juan, Ciudad Real, Spain, and others)

Chapter 4. Treatment of Thrombotic Thrombocytopenic Purpura during Pregnancy
(A. Fuentes Rozalén, MD, Y. Ben-Aïcha González, MD, L. Belmonte Andújar, MD, Instituto Bernabeu, Alicante, Spain, and others)

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