Therapeutic Advances in Human Health and Diseases

$230.00

Sushil Kumar Upadhyay, PhD – Associate Professor, Department of Bio-Sciences and Technology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, India
Manoj Singh, PhD – Associate Professor, Department of Bio-Sciences and Technology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, India
Anil Kumar Sharma – Professor, Department of Biotechnology, Amity University, Mohali, Punjab, India

Series: New Developments in Medical Research
BISAC: MED000000
DOI: https://doi.org/10.52305/LVLG8834

The book has imperative and up-to-date information on the basics to advanced therapeutic approaches against various life-threatening diseases including vector and parasite-borne diseases, COVID-19, Mucormycosis, and cancer as well. The book harbors extensive knowledge about the applications and effective utilization of advanced personalized medicines, target-based nanoencapsulated phytochemicals, and herbal nanomedicines against life-threatening diseases including cancer, thereby having implications in the cancer biology field encompassing pharmaceutical and life science sectors considerably. Moreover, the proposed book would provide a strong platform for delineating the complex mechanism underlying the disease therapeutics along with the potential therapies countering the existing menace of drug resistance, especially concerning cancer. More so the book will showcase the recent advances in the use of nanocomposite films and molecular-mediated drug delivery for therapeutic applications.

The uniqueness of this book is to provide all the possible information from basics to advanced nano-therapeutics at a single platform making it a valuable informative source to the graduates of various universities across the globe to understand multifaceted therapeutic applications against life-threatening diseases. The book is an outstanding compilation comprising comprehensive information on therapeutic advances at a single platform. The book is apt to the present needs and well aligned with the offered curricula in Universities across the globe for UG, PG, and Ph.D. programs encompassing life sciences, medical, paramedical, and pharmaceutical courses. The diversity of chapters in the book are going to covers various aspects of the parasites, pathophysiology, and pathogenesis along with the pivotal role of nanotechnology in drug discovery and nano-biosensors for the detection of coronavirus as well. Moreover, the book has interesting elements of futuristic personalized medicines in combating coronavirus along with remedial therapeutic measures against coronavirus-induced mucormycosis. Another chapter deals with multifaceted therapeutic advances in life-threatening human diseases from traditional, complementary, and integrative medicine to nano-based targeted drug delivery. In the end, the authors have shed light on understanding oncogenesis and cancer and finding an amicable therapeutic nanomedicine solution paving the way towards individualized medicine therapeutics against cancer.

With the advent of newer technologies such as combinatorial chemistry high-throughput screening, next generation sequencing, it is now possible to consider that nanotherapeutics and personalized medicines could be the sound death knell for a variety of dreadful diseases including cancer and also to deal with the growing menace of drug-resistance. Once again, our sincere thanks to all the contributing authors who worked like a team to let us complete this book. Special thanks to the Editorial team of the publishing house who were available all the time to impart their valuable input and assistance. Words of appreciation also go to the whole Production Team as well.

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Table of Contents

Preface

Chapter 1. Parasites and Pathogenesis: Disease Etiology, Progression, Control Measures and Advancements in Therapeutic Strategies
Sushil Kumar Upadhyay1, Manoj Singh1, Mukesh Yadav1, Nirmala Sehrawat1, Mayank Raj1, Siddhartha Dan2, Kiran Upadhyay3, Yogendra Prasad Pandey4, Vikas Kumar5, Sunil Kumar6, Prabhakar Mishra7, Mukesh Kumar1, Nisha Kashyap8, Raj Singh1 and Anil Kumar Sharma9
1Department of Bio-Sciences and Technology, M. M. E. C., Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, India
2Department of Biotechnology, Dr. B. R. Ambedkar, National Institute of Technology, Jalandhar, Punjab, India
3Department of Zoology, K. P. Higher Education Institute, Jhalwa–Prayagraj, Uttar Pradesh, India
4Department of Zoology, Government Model Science College, Rewa, MP, India
5Department of Microbiology, International Medical School, UIB, Almaty, Kazakhstan
6Department of Microbiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Ishaka, Uganda
7Department of Biotechnology, School of Applied Sciences, REVA University, Bengaluru, Karnataka, India
8Department of Medical Microbiology, PGIMER, Chandigarh, India
9Department of Biotechnology, Amity University, Mohali, Punjab, India

Chapter 2. Parasites and Parasitic Diseases in Human: Risks, Challenges and Therapeutic Strategies
Preeti Baxi1, Nishant Srivastava2 and Manoj Singh3
1Phytosanitary Laboratory, Department of Plant Molecular Biology and Biotechnology, Indira Gandhi Agriculture University, Raipur, India
2Avishka Council of Industrial and Allied Biosciences (ACIAB), Greater Noida, India
3Department of Bio-Sciences and Technology, M.M.E.C., Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala (Haryana), India

Chapter 3. The Role of Nanobiotechnology in Drug Discovery: Recent Developments, Molecular Diagnostics and Future Prospects
Mayank Raj1, Manoj Singh1,2, Tamanna Devi1, Vikas Kumar1,3, Sushil Kumar Upadhyay1 and Mukesh Yadav1
1Department of Bio-Sciences and Technology, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, India
2Laboratory of Biomedical Nanomaterials, National University of Science and Technology “MISiS,” Moscow, Russia
3Department of Microbiology, International Medical School, UIB, Almaty, Kazakhstan

Chapter 4. Nanotechnology-Based Biosensors to Detect Coronavirus
Tamanna Devi1, Mayank Raj1, Manoj Singh1,2, Sushil Kumar Upadhyay1, Nirmala Sehrawat1, Vikas Kumar1, 3, Prabhakar Mishra4 and Nishant Srivastava5
1Department of Bio-Sciences and Technology, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, India
2Laboratory of Biomedical Nanomaterials, National University of Science and Technology “MISiS,” Moscow, Russia
3Department of Microbiology, International Medical School, UIB, Almaty, Kazakhstan
4Department of Biotechnology, School of Applied Sciences, REVA University, Bengaluru, Karnataka, India
5Avishka Council of Industrial and Allied Biosciences, Greater Noida, India

Chapter 5. Recent Advancements in the Major Risk Factors and Treatment of SARS-CoV-2: A New Paradigm of Medicine in the Strategic Combating of the COVID-19 Pandemic
Mansi Srivastava1, Siddhartha Dan2, Shruti Jain3, Prem Shankar Mishra4 and Abid Ali Sheikh5
1Department of Bioscience and Biotechnology, Banasthali Vidyapith, Banasthali, Rajasthan, India
2Department of Biotechnology, Dr. B. R. Ambedkar National Institute of Technology, Jalandhar, Punjab, India
3Institute of Bioinformatics and Applied Biotechnology, Bengaluru, Karnataka, India
4Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India
5Training Official Scientific, National Institute of Biologicals, Noida, Uttar Pradesh, India

Chapter 6. Coronavirus Disease (SARS-CoV-2) Associated Mucormycosis (Zygomycosis): Stochastic Assemblages, Causes, Cures and Epidemiology
Mohit Pant1, Siddhartha Dan2,3, Samyak Nag4, Lajpreet Kaur5, Rashmi Pandey6, Himanshu Ojha5 and Mallika Pathak7
1Department of Pharmacovigilance, Parexel International Pvt. Ltd., Mohali, Punjab, India
2Department of Biotechnology, I. K. Gujral Punjab Technical University, Jalandhar, Punjab, India
3Department of Biotechnology, Dr. B. R. Ambedkar National Institute of Technology, Jalandhar, Punjab, India
4Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India
5CBRN Protection and Decontamination Research Group, Division of CBRN Defence, Institute of Nuclear Medicine and Allied Sciences, DRDO, Timarpur, Delhi, India
6Guru Gobind Singh Indraprastha University, Dwarka, Delhi, India
7Department of Chemistry, Miranda House, University of Delhi, Delhi, India

Chapter 7. Mucormycosis and Associated Infections in Immunocompromised COVID-19 Patients: From Pathogenesis, Advances in Diagnosis, Treatment, Pharmacology to Nanotherapy
Siddhartha Dan1,2, Mohit Pant3, Bhawana Paliwal4, Subashani5, Samyak Nag6, Nikul B. Chavada7 and Sushil Kumar Upadhyay8
1Department of Biotechnology, I. K. Gujral Punjab Technical University, Jalandhar, Punjab, India
2Department of Biotechnology, Dr. B. R. Ambedkar National Institute of Technology; Jalandhar, Punjab, India
3Department of Pharmacovigilance, Paraxel International (India) Private Limited, Chandigarh, India
4Department of Bioscience and Biotechnology, Banasthali Vidyapith, Banasthali (Rajasthan), India
5Department of Biochemistry, Institute of Biosciences and Biotechnology, Chhatrapati Shahu Ji Maharaj University, Kanpur, Uttar Pradesh, India
6Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India
7OM College of Science and PG Center, Bhesan -Junagadh Road, Junagadh, Gujarat, India
8Department of Bio-Sciences and Technology, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana–Ambala (Haryana), India

Chapter 8. Advancements in the Testing Methods of SARS-CoV-2: From Conventional Clinical Diagnostic, Serological, Rapid-Biomolecular Tests to Nanobased Biosensors
Siddhartha Dan1,2, Pritika Dutta3, Pallavi Dutta4, Deeksha Sharma5, Sakshi Tyagi6, Sushil Kumar Upadhyay7 and Anil K. Sharma8
1Department of Biotechnology, I. K. Gujral Punjab Technical University, Jalandhar, Punjab, India
2Department of Biotechnology; Dr. B. R. Ambedkar National Institute of Technology, Jalandhar, Punjab, India
3Department of Physiology, All India Institute of Medical Sciences, New Delhi, India
4Department of Biotechnology, Jawaharlal Nehru University, New Delhi, India
5Faculty of Applied Sciences and Biotechnology, Shoolini University, Solan, Himachal Pradesh, India
6Department of Biotechnology, Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India
7Department of Bio-Sciences and Technology, M.M.E.C., Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala (Haryana), India
8Department of Biotechnology, Amity University, Mohali, Punjab, India

Chapter 9. Multifaceted Therapeutics Advances in Life-Threatening Human Diseases: From Traditional, Complementary and Integrative Medicine to Nano-Based Targeted Drug Delivery
Siddhartha Dan1, Deeksha Sharma2 and Sushil Kumar Upadhyay3
1Department of Biotechnology, Dr. B. R. Ambedkar, National Institute of Technology, Jalandhar (Punjab), India
2Faculty of Applied Sciences and Biotechnology, Shoolini University, Solan, Himachal Pradesh, India
3Department of Bio-Sciences and Technology, M. M. E. C., Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala (Haryana), India

Chapter 10. Current Paradigms in Understanding Oncogenesis and Cancer: From Basics to Advanced Personalized Medicines and Targeted Nanotherapeutics
Varruchi Sharma1, Sonal Datta2, Atul Sankhyan3, Anil Panwar4, Diwakar Aggarwal2, Sushil Kumar Upadhyay2, Manoj Singh2, Amit Joshi1, Poonam Bansal2 and Anil K Sharma5
1Department of Biotechnology & Bioinformatics, Sri Guru Gobind Singh College, Chandigarh, India
2Department of Bio-Sciences and Technology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, (Haryana), India
3Department of Public Health Dentistry, HPGDCH, Shimla, India
4Department of Molecular Biology, Biotechnology & Bioinformatics, College of Basic Sciences & Humanities, CCS Haryana Agricultural University, Hisar, Haryana
5Department of Biotechnology, Amity University, Mohali, Punjab, India

Index

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