The Use of Chitosan in Basic Studies and Clinical Application in Urinary Bladder Epithelium

Andreja Erman and Peter Veranic
University of Ljubljana, Slovenia, EU

Series: Biotechnology in Agriculture, Industry and Medicine
BISAC: SCI010000

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Volume 10

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Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Chitosan is a cationic polysaccharide mainly used as an absorption enhancer. Its known low toxicity for most tissues gave it a wide applicability in the local delivery of pharmaceutics to selected tissues. The positive charge of the chitosan enable it to attach to the mainly negatively charged proteoglycans that cover apical surface of most epithelial cells and allow a gradual release of the drugs trapped in this polysaccharide cage. The intravesical application of chitosan to urinary bladder recently revealed an unpredicted deteriorating effect on superficial epithelial cells. This book examines the current understanding of the effects of chitosan on urinary bladder epithelial cells. (Imprint: Nova Biomedical)

ABSTRACT

INTRODUCTION

EFFECT OF CHITOSAN ON TIGHT JUNCTION PERMEABILITY

CHITOSAN INDUCES DESQUAMATION OF UROTHELIAL CELLS

CHITOSAN AND TREATMENT OF BACTERIAL CYSTITIS

CONCLUSION

REFERENCES

INDEX

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