The Strict Concept of Specificity as Multiple Sclerosis Pathogenesis


Lawrence M Agius
University of Malta Medical School, Mater Dei Hospital, Msida, Malta

Series: Neuroscience Research Progress
BISAC: MED057000
DOI: 10.52305/NJYG2510

This monograph approaches from various angles the problematic difficulties of definition of multiple sclerosis. Although no figures or tables are included, a schematic series of attempts are made in terms of short review style the overall and specific highlights of pathologic involvement of the central nervous system in neurodegeneration,neuroinflammation and demyelination as seen in autopsy material.

A clear concise style has been adopted that allows however the establishment of comprehensive inclusion of various pathogenic features of operative schematization of current understanding in MS pathogenesis. This volume is particularly suitable in view of the organic structuring of various operative factors in MS that interest students, post-graduates researchers of various disciplines, and also integrative information of interest to clinicians in active clinical investigations, and also pathologists and neuropathologists.

Table of Contents


Chapter 1. The Adaxonal Myelin Layer Triggers and Destabilizes Multiple Sclerosis Pathogenesis.

Chapter 2. Pathogenic Systems of Heterogeneity in Distinct Onset versus Progression Phases of Multiple Sclerosis in Terms of Amplifying Overlap of Immune Reactivities

Chapter 3. Variability of Expressivity in Multiple Sclerosis Involves Pathogenic Diversity in Lesion Progression and in Attempted Lesion Reconstitution

Chapter 4. Tightly Coupled Demyelination and Remyelination Constitute Basic Biology of Persistence in the Multiple Sclerosis Plaque in Terms of Neuronal/axonal Primal Injury Progression

Chapter 5. The Essential Links between Genetic Susceptibility and Environmental Pathogens in Multiple Sclerosis Progression and Initiation

Chapter 6. Performance Reactivation of Immune Response Defines Multiple Sclerosis Progression as Systems of Overlap Spread and Amplification via Endothelial Cells

Chapter 7. A Multi-Factorial Genesis of the Multiple Sclerosis Triggering Event and of the Propagation of Progressing Lesions in the Central Nervous System

Chapter 8. Attributes of Patterned Injury in Multiple Sclerosis Sequential Plaque Definition—the Primal Vascular Wall Paradigm

Chapter 9. Integral Biologic System-Induced Energy Failure Allows and Further Establishes Neurodegeneration and Inflammatory Demyelination in Multiple Sclerosis

Chapter 10. Constitutive and Acquired Formulas of Transformation in Multiple Sclerosis

Chapter 11. The Outcome of the Individual Multiple Sclerosis Plaque as Pre-Determined Parameter in Disease Progression or Potential Recovery

Chapter 12. Elemental Context Definition in Integral Geography of Multiple Sclerosis Lesions

Chapter 13. An Integral Formulation of Targeting Combinations of the Innate and Adaptive Immune Systems in Ms in Terms of Activated Vasculitis

Chapter 14. Dimensions of Co-Operative Overlap of a Primal Autoimmunity of Contactual Repeated Antigenic Characterization in Multiple Sclerosis

Chapter 15. Autoimmunity as Specific Enhanced Response to Cell Injury in Multiple Sclerosis Persistence and Re-Modulation in Terms of the Gut Microbiota Reconstitutive Profiles

Chapter 16. Systems of Integrity as Interacting and Individual Subsystems in Multiple Sclerosis Networks in Terms of Cns Impaired Immune Privileged Status in Neuroinflammation

Chapter 17. Instability of the Inflammasome Induces Eventual Autoimmunity in Multiple Sclerosis

Chapter 18. Diversity in Injury Pathways Incorporated as Unitary Targeting Events in Multiple Sclerosis

Chapter 19. An Essential Permissive Microenvironment as Primarily Passive Accumulation of Multiple Sclerosis Lesion Byproducts Redefines Disease Pathogenesis

Chapter 20. Proposed Dynamics of Predetermination of Multiple Sclerosis Injury in Terms of Concurrent Potentiality for Recovery

Chapter 21. Interface Interactivities as Systemic Biology Reconstitution in Multiple Sclerosis

Chapter 22. Profiles of Transforming Activations of Immune Cells as Infiltrative Dimensions in Definition of T Cd4+ Helper Cells in Neuroinflammation of Multiple Sclerosis Type


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