The Stellate Cell (Vitamin A-Storing Cell) System

Haruki Senoo
Akita University School of Medicine, Akita-City, Akita, Japan

Series: Cell Biology Research Progress
BISAC: SCI017000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Past, present and future research of hepatic stellate cells (HSCs; also called vitamin A-storing cells, lipocytes, interstitial cells, fat-storing cells, Ito cells) are summarized and discussed in this review. Kupffer discovered black-stained cells in the liver by the gold chloride method and named the cells the stellate cells (Sternzellen in German) in 1876. Wake re-discovered the cells in 1971 using the same gold chloride method and various modern histological techniques including electron microscopy.

Between the discovery and re-discovery, the HSCs disappeared from the history of research. Identification, establishment of cell isolation and culture methods, and the development of cellular and molecular biological techniques have promoted HSC research after the re-discovery of the cell. The research is entering a new era, namely, the golden age after the dark ages. In the future, the research of HSCs will develop more into not only the clinical field, but also into the basic research fields. In this book, we describe the past, present and future of HSC research. (Imprint: Nova Biomedical )


Chapter 1. Introduction

Chapter 2. Morphology of HSCs

Chapter 3. Functions of HSCs

Chapter 4. Relation with other Cells in the Liver

Chapter 5. Extrahepatic Stellate Cells

Chapter 6. Aging and HSCs

Chapter 7. Roles of HSCs during Liver Regeneration

Chapter 8. Hepatic Diseases and HSCs

Chapter 9. Immunity and HSCs

Chapter 10. Epigenetics of HSCs

Chapter 11. Artificial Organs and HSCs

Chapter 12. Global Climate Change and HSCs

Chapter 13. Conclusion




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