The Role of the Transcriptional Regulator Snail in Development and Cancer Biology

Chun-Yu Lin
Pei-Hsun Tsai
Kevin P-H Lee
Jhen-Jia Fan
Chithan C. Kandaswami
Hsiao Pei-Wen
Ming-Ting Lee

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

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Volume 10

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Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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The Snail superfamily of zinc-finger transcription factors are involved in processes that result in pronounced cell movement during embryonic development and are also associated with the acquisition of invasive and migratory properties during tumor progression. Snail was first described in Drosophila melanogaster, where it was shown to be essential for the formation of the mesoderm. The absence of Snail is lethal, causing severe defects during the gastrula stage of development. Snail is mainly expressed in neoplastic epithelial cells. Understanding the regulation and functional roles of Snail will shed new light on the mechanisms involved in tumor progression and help with the development of novel cancer therapies. (Imprint: Nova)

Abstract

Introduction

Regulation of Snail expression

The role of Snail in development

Role of Snail in the epithelial-to-mesenchymal transition (EMT) and cancer metastasis

Conclusion

Acknowledgments

References

Index

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